INT64280

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 22
Total Number 25
Disease Relevance 14.90
Pain Relevance 7.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
PGE2 3
neuronal 2
PGE1 1
bladder 1
dorsal root ganglia 1
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 73 100.00 Very High Very High Very High
Glutamate 21 99.74 Very High Very High Very High
Pain 55 99.66 Very High Very High Very High
Glutamate receptor 15 99.60 Very High Very High Very High
allodynia 14 99.46 Very High Very High Very High
qutenza 155 98.70 Very High Very High Very High
cytokine 24 98.60 Very High Very High Very High
Thermal hyperalgesia 45 98.56 Very High Very High Very High
nMDA receptor 7 97.78 Very High Very High Very High
Dorsal horn 2 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 162 99.92 Very High Very High Very High
Adenocarcinoma 30 99.84 Very High Very High Very High
Ovarian Cancer 294 99.76 Very High Very High Very High
Cancer 430 99.66 Very High Very High Very High
Pain 51 99.66 Very High Very High Very High
Neuropathic Pain 15 99.46 Very High Very High Very High
Malignant Neoplastic Disease 308 98.68 Very High Very High Very High
Hyperalgesia 54 98.56 Very High Very High Very High
Asthma 2 97.84 Very High Very High Very High
Nociception 44 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This segregation of EP receptor function within the airway suggests that PGE(2) analogs that selectively activate the EP2 receptor without activating the EP1/EP3 receptors might prove useful in the treatment of asthma.
Neg (without) Positive_regulation (activating) of EP1 associated with asthma
1) Confidence 0.67 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618422 Disease Relevance 0.10 Pain Relevance 0
These results suggest that EP1 receptor was present in bladder urothelium, and could be activated by PGE2 to release ATP.
Positive_regulation (activated) of EP1 in bladder
2) Confidence 0.50 Published 2008 Journal Biomed. Res. Section Abstract Doc Link 18480552 Disease Relevance 0.14 Pain Relevance 0.46
These data clearly show that TRPV1 currents evoked by any of three different stimuli (capsaicin, proton, or heat) are potentiated or sensitized by PGE2 through EP1 receptor activation.
Positive_regulation (activation) of EP1 receptor associated with qutenza
3) Confidence 0.50 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.25
These results demonstrate that the PGE2-induced allodynia, once developed, does not require the continued agonist occupancy of EP1 and NMDA glutamate receptor sites.
Neg (not) Positive_regulation (require) of EP1 in PGE2 associated with allodynia, glutamate receptor and agonist
4) Confidence 0.45 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8786849 Disease Relevance 0.59 Pain Relevance 0.85
The present findings confirmed a role for endogenous PGE2 produced by COX-1 in adaptive gastric cytoprotection and suggested that this action is mediated by activation of EP1-receptors but not associated with capsaicin-sensitive afferent neurons.
Positive_regulation (activation) of EP1 in afferent neurons associated with qutenza
5) Confidence 0.43 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11356942 Disease Relevance 0.25 Pain Relevance 0.28
Oppositely, heat pain sensitivity was increased in FP, EP1 and EP1+3 double mutant mice possibly due to a loss of FP or EP1 receptor mediated central control of thermal pain sensitivity.
Spec (possibly) Positive_regulation (increased) of EP1 associated with pain
6) Confidence 0.43 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938093 Disease Relevance 1.31 Pain Relevance 0.98
Oppositely, heat pain sensitivity was increased in FP, EP1 and EP1+3 double mutant mice possibly due to a loss of FP or EP1 receptor mediated central control of thermal pain sensitivity.
Spec (possibly) Positive_regulation (increased) of EP1 associated with pain
7) Confidence 0.43 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938093 Disease Relevance 1.31 Pain Relevance 0.99
Thus, the potentiation or sensitization of TRPV1 activity through EP1 or IP activation might be one important mechanism underlying the peripheral nociceptive actions of PGE2 or PGI2.



Positive_regulation (activation) of EP1 in PGE2 associated with nociception
8) Confidence 0.36 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1074353 Disease Relevance 0.56 Pain Relevance 0.28
These results suggest that a PKC-dependent pathway downstream of EP1 activation is mainly involved in PGE2-induced thermal hyperalgesia.
Positive_regulation (activation) of EP1 associated with thermal hyperalgesia
9) Confidence 0.36 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.96 Pain Relevance 0.86
The activation of EP1 elevates the levels of intracellular inositol phosphate and Ca2+ (Watabe et al. 1993), whereas the activation of EP2 or EP4 stimulates adenylate cyclase, resulting in increased levels of intracellular cAMP (Jumblatt and Paterson, 1991).
Positive_regulation (activation) of EP1
10) Confidence 0.30 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.05 Pain Relevance 0.28
Activation of EP1 contributes to neuronal excitotoxic death, in contrast to activation of EP2 [51-53] and EP4 [50] which promote neuroprotection [see [49] for review].
Positive_regulation (Activation) of EP1 in neuronal associated with death
11) Confidence 0.28 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2873241 Disease Relevance 0.63 Pain Relevance 0
The physiological actions of PGE1 and prostaglandin E2 (PGE2) are mediated by the prostaglandin E receptor subtypes EP1, EP2, EP3, and EP4 [6,7].
Positive_regulation (mediated) of PGE1 in PGE1
12) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.61 Pain Relevance 0.16
In conscious mice the administration of PGE(2) increased airway responsiveness primarily through the EP1 receptor, although on certain genetic backgrounds a contribution of the EP3 receptor was detected.
Positive_regulation (increased) of EP1 receptor
13) Confidence 0.27 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618422 Disease Relevance 0 Pain Relevance 0
Significant (p < 0.05) increases of COX-1, COX-2, mPGES-1 and EP1 were demonstrated in the adenocarcinomas (AC) in comparison with normal ovarian tissue, benign adenomas and borderline tumours (B/BL) (Figure 1, 2, 3, 4, 5).
Positive_regulation (increases) of EP1 associated with adenoma, adenocarcinoma, malignant neoplastic disease and cancer
14) Confidence 0.20 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.93 Pain Relevance 0
EP1 was increased in stage III while no significant alterations were demonstrated for COX-1, mPGES-1 or EP2 for stage.
Positive_regulation (increased) of EP1
15) Confidence 0.20 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1657027 Disease Relevance 0.92 Pain Relevance 0.08
The increases of COX-1, COX-2, mPGES-1 and EP1–2 in epithelial ovarian cancer, supports the hypothesis that PGE2-synthesis and signalling are of importance for malignant transformation and progression.
Positive_regulation (increases) of EP1 associated with malignant neoplastic disease and ovarian cancer
16) Confidence 0.20 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1657027 Disease Relevance 0.92 Pain Relevance 0.05
IHC revealed staining of the tumour cells, but also increase of COX-1, COX-2, mPGES-1 and EP1–2 in the stromal compartment of AC (grades: moderately-, poorly- and undifferentiated).
Positive_regulation (increase) of EP1 associated with malignant neoplastic disease and cancer
17) Confidence 0.20 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1657027 Disease Relevance 1.00 Pain Relevance 0.04
The cell- and stage specific increases of COX-1, COX-2, mPGES-1 and EP1–2, support the hypothesis that PGE2-synthesis and signalling are of importance for malignant transformation and progression in EOC.
Positive_regulation (increases) of EP1 associated with malignant neoplastic disease and ovarian cancer
18) Confidence 0.20 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.60 Pain Relevance 0.03
An increase was also shown for EP1 in stage III tumours compared to stage I.
Positive_regulation (increase) of EP1 associated with cancer
19) Confidence 0.20 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.54 Pain Relevance 0
Increases of COX-1, COX-2, mPGES-1 and EP1 in adenocarcinomas
Positive_regulation (Increases) of EP1 associated with adenocarcinoma
20) Confidence 0.20 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.80 Pain Relevance 0

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