INT6431

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Context Info
Confidence 0.24
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 36
Total Number 36
Disease Relevance 8.08
Pain Relevance 10.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ass1) endoplasmic reticulum (Ass1) nucleus (Ass1)
ligase activity (Ass1) lysosome (Ass1) cytoplasm (Ass1)
Anatomy Link Frequency
ZR-75-1 2
lungs 2
retina 1
alveolar macrophages 1
brain 1
Ass1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 61 100.00 Very High Very High Very High
substance P 10 100.00 Very High Very High Very High
Antinociceptive 6 100.00 Very High Very High Very High
Hippocampus 41 99.68 Very High Very High Very High
cocaine 28 99.66 Very High Very High Very High
qutenza 4 99.54 Very High Very High Very High
Enkephalin 10 99.50 Very High Very High Very High
fluoxetine 20 98.64 Very High Very High Very High
calcitonin gene related peptide 10 98.02 Very High Very High Very High
Morphine 366 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Crystal Associated Disease 30 98.96 Very High Very High Very High
Overactive Bladder 32 97.60 Very High Very High Very High
Injury 17 97.24 Very High Very High Very High
Targeted Disruption 290 96.36 Very High Very High Very High
Dysmenorrhea 5 93.52 High High
Primary Sclerosing Cholangitis 6 93.08 High High
Sprains And Strains 167 91.84 High High
Alzheimer's Dementia 160 90.80 High High
Recurrence 2 86.92 High High
Hepatotoxicity 40 86.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The risk of diabetes increased 1.32-fold after the onset of pancreatic calcification.
Positive_regulation (increased) of 1.32-fold
1) Confidence 0.24 Published 2007 Journal J. Gastroenterol. Section Body Doc Link 17464458 Disease Relevance 0.14 Pain Relevance 0
Despite the lack of LM effect on transit in young mice, IL-6 and COX-2 mRNA expressions were significantly increased postoperatively (165 +/- 24-fold and 2.9 +/- 0.3-fold, respectively).
Positive_regulation (increased) of 0.3-fold
2) Confidence 0.22 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17363464 Disease Relevance 0.37 Pain Relevance 0.16
IL-10 and heme oxygenase-1 gene expressions were also elevated postoperatively in young mice (4.8 +/- 0.5-fold and 13.0 +/- 1.3-fold, respectively) and were further increased in middle-aged mice (7.5 +/- 0.6-fold; 21.8 +/- 3.2-fold).
Positive_regulation (elevated) of 0.5-fold
3) Confidence 0.22 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17363464 Disease Relevance 0.42 Pain Relevance 0.21
IL-10 and heme oxygenase-1 gene expressions were also elevated postoperatively in young mice (4.8 +/- 0.5-fold and 13.0 +/- 1.3-fold, respectively) and were further increased in middle-aged mice (7.5 +/- 0.6-fold; 21.8 +/- 3.2-fold).
Positive_regulation (elevated) of 1.3-fold
4) Confidence 0.22 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17363464 Disease Relevance 0.42 Pain Relevance 0.21
The maximal effect was observed on day 6 when the ED50 of mice treated with 8.4 mumol/kg of dyn A(1-13) was increased nearly 6-fold over that of saline controls.
Positive_regulation (increased) of nearly 6-fold
5) Confidence 0.16 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7714779 Disease Relevance 0.07 Pain Relevance 0.77
Capsaicin, heat and pH 5.2 were able to induce significant increases in calcitonin gene related peptide (CGRP) release (14.6-, 5.1-, and 2.3-fold over baseline), however, only capsaicin induced a significant increase in substance P (SP) levels (1.8-fold over baseline).
Positive_regulation (increase) of 1.8-fold associated with calcitonin gene related peptide, qutenza and substance p
6) Confidence 0.13 Published 2001 Journal Pain Section Abstract Doc Link 11514080 Disease Relevance 0.21 Pain Relevance 0.91
Only the 90 mmHg distension evoked a significant increase of SP (1.9-fold over baseline).
Positive_regulation (increase) of 1.9-fold associated with substance p
7) Confidence 0.13 Published 2001 Journal Pain Section Abstract Doc Link 11514080 Disease Relevance 0.15 Pain Relevance 0.73
Concurrent with these changes, sensory activity increased 2.8-fold during filling and 2.4-fold at threshold pressure.
Positive_regulation (increased) of 2.8-fold
8) Confidence 0.10 Published 2010 Journal Frontiers in Neurology Section Abstract Doc Link PMC3008862 Disease Relevance 0.24 Pain Relevance 0
Stimulation with PAM3 also significantly increased elastance (1.9-fold and 2.4-fold, respectively) (P < 0.05).
Positive_regulation (increased) of 1.9-fold
9) Confidence 0.03 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.05 Pain Relevance 0.03
Interestingly, the large molecular weight enkephalin-containing peptides are elevated 2-3-fold in Cpefat/Cpefat mouse brain.
Positive_regulation (elevated) of 2-3-fold in brain associated with enkephalin
10) Confidence 0.02 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8940036 Disease Relevance 0 Pain Relevance 0.36
The mRNA transcripts for TSP-1 and TSP-2 were increased, 16-fold and 87-fold respectively, in the pancreas in response to repetitive injury.
Positive_regulation (increased) of 16-fold in pancreas associated with injury
11) Confidence 0.02 Published 2006 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 16181801 Disease Relevance 1.39 Pain Relevance 0.23
Similarly administration of BNTX, i.t. increased the antinociceptive ED50 value of DPDPE 4-fold without altering significantly that of DELT II.
Positive_regulation (increased) of DPDPE 4-fold associated with antinociceptive
12) Confidence 0.02 Published 1993 Journal Life Sci. Section Abstract Doc Link 8383271 Disease Relevance 0 Pain Relevance 1.11
It was up-regulated 18-fold in the luminal epithelium following dosing with tamoxifen but not raloxifene.
Positive_regulation (up-regulated) of 18-fold in epithelium
13) Confidence 0.02 Published 2003 Journal J. Mol. Endocrinol. Section Abstract Doc Link 12580757 Disease Relevance 0.18 Pain Relevance 0.50
Up-regulation of Tsc22d3 was associated with an increase in the corresponding protein level (approximately 1.5-fold; Figure 5c).
Positive_regulation (increase) of 1.5-fold
14) Confidence 0.01 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.06 Pain Relevance 0.32
Equal upregulation (about 1.5-fold to 2-fold) of mRNAs for serum/glucocorticoid regulated kinase 3 (Sgk3) and calcium/calmodulin-dependent protein kinase I gamma (Camk1g) was observed after acute and chronic morphine exposure in all four strains of mice.
Positive_regulation (upregulation) of 1.5-fold associated with sprains and strains and morphine
15) Confidence 0.01 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.38 Pain Relevance 0.50
In contrast, only 76 (13 with >1.5-fold) were upregulated after chronic treatment (Table 2).
Positive_regulation (upregulated) of 1.5-fold
16) Confidence 0.01 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.14 Pain Relevance 0.73
By microarray analysis AI expression in the gravid wild-type uterus is increased 4.6-fold on d19.0 compared to d13.5 [24].
Positive_regulation (increased) of 4.6-fold in uterus
17) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1941732 Disease Relevance 0.30 Pain Relevance 0
Analysis of cathepsin K mRNA and protein levels in lysates of resident alveolar macrophages and lung homogenates revealed 9.3-fold and 6.4-fold upregulated cathepsin K mRNA levels in alveolar macrophages and lung homogenates, respectively of the transgenic mice as compared to mock-treated wild-type mice (Figure 1A).
Positive_regulation (upregulated) of 9.3-fold in lung associated with targeted disruption
18) Confidence 0.01 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.19 Pain Relevance 0.07
Quantitatively, Ki67-positive proliferating cells in the hippocampal SGZ and GCL were increased 1.9-fold, BrdU-positive cells 1.58-fold, and Ki67/BrdU double-positive proliferating cells 1.64-fold in Tdo-/- over Tdo+/+ mice (Figure 5C–5F).
Positive_regulation (increased) of 1.9-fold
19) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.05 Pain Relevance 0.11
The activities of both enzymes increased by 5- to 6-fold or 15- to 17-fold with saposin C (0 to 500 nM) or BPS (0 to 2 µM), respectively.
Positive_regulation (zymes inc) of 17-fold
20) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0

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