INT64346

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 95
Total Number 98
Disease Relevance 63.11
Pain Relevance 9.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
Anatomy Link Frequency
brain 10
neuron 7
smooth muscle 5
fat 4
Histiocytes 2
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 51 100.00 Very High Very High Very High
antidepressant 365 99.80 Very High Very High Very High
iatrogenic 29 99.54 Very High Very High Very High
ischemia 5 99.48 Very High Very High Very High
fluoxetine 26 99.10 Very High Very High Very High
Inflammatory response 45 99.04 Very High Very High Very High
Somatostatin 5 98.84 Very High Very High Very High
depression 166 98.70 Very High Very High Very High
Neuropathic pain 1 98.36 Very High Very High Very High
tricyclic antidepressant 4 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Injury 416 99.96 Very High Very High Very High
Cerebral Malaria 24 99.84 Very High Very High Very High
Neurodegenerative Disease 100 99.76 Very High Very High Very High
Sepsis 419 99.72 Very High Very High Very High
Cancer 253 99.72 Very High Very High Very High
Depression 510 99.60 Very High Very High Very High
Lipoma 2 99.60 Very High Very High Very High
Infection 127 99.56 Very High Very High Very High
Creutzfeldt Jakob Disease 108 99.48 Very High Very High Very High
Cv General 4 Under Development 10 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently Schulpis et al [13] investigated the effect of the mode of labour and delivery on the protein S100B serum concentrations in mothers and their newborns and demonstrated an increase of S100B serum levels in the mothers who delivered with prolonged labour for natural way.
Positive_regulation (increase) of S100B
1) Confidence 0.70 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.15 Pain Relevance 0.03
The hypothesis that the abnormal elevation of S100B in colostrums of Burkinabe woman could be a consequence of immunological stress due to infections affected the mothers, was excluded by the fact that the mothers were admitted to this study only after exclusion of HIV infection, sexual transmitted diseases and mastitis.
Positive_regulation (elevation) of S100B in colostrums associated with staphylococcus infection, stress, acquired immune deficiency syndrome or hiv infection, disease and infection
2) Confidence 0.70 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 1.07 Pain Relevance 0.08
Our study showed that an increase in fat mass might not in isolation be a major contributor to elevated S100B levels.
Positive_regulation (elevated) of S100B in fat
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 1.19 Pain Relevance 0.04
Prior studies have shown that cardiothoracic surgeries resulted in higher serum levels of S100B.
Positive_regulation (resulted) of S100B
4) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 1.09 Pain Relevance 0.03
We chose fat tissue because it was most consistently reported in the literature to contribute to elevated serum S100B levels [19], [20].
Positive_regulation (elevated) of S100B in fat
5) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.08 Pain Relevance 0
There was a highly significant temporal effect with increases in NSE (2.2 +/- 1.6 ng/L to 11.8 +/- 8.9 ng/L; P < 0.0001) (mean +/- sd) and S-100beta (0.15 +/- 0.1 microg/L to 0.45 +/- 0.42 microg/L, P < 0.0001).
Positive_regulation (increases) of S-100beta
6) Confidence 0.67 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15502024 Disease Relevance 0.25 Pain Relevance 0.19
At 8 and 24 h after induction of anesthesia S-100beta (0.28 +/- 0.18 microg/L versus 0.91 +/- 0.54 microg/L; P =0.004) and NSE (8.6 +/- 5.6 ng/L versus 19.0 +/- 19.7 ng/L; P = 0.02) levels, respectively, were higher in patients with the Apoepsilon4 allele.
Positive_regulation (induction) of S-100beta associated with anesthesia
7) Confidence 0.67 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15502024 Disease Relevance 0.24 Pain Relevance 0.19
In comparison to the pre-bypass values, a similar increase in the concentration of protein S-100beta was found 2 hours after the termination of CPB in the SNP-treated and non-treated neonates, which decreased over the subsequent 48 postoperative hours.
Positive_regulation (increase) of S-100beta
8) Confidence 0.67 Published 2000 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 11156353 Disease Relevance 0.20 Pain Relevance 0.09
CONCLUSIONS: Despite reports about the neuroprotective effects of propofol, S-100beta protein levels were significantly elevated in group P.
Positive_regulation (elevated) of S-100beta
9) Confidence 0.67 Published 2004 Journal Can J Anaesth Section Body Doc Link 15310641 Disease Relevance 0 Pain Relevance 0
Alternatively, Florio et al. documented increased levels of S100B in urine samples from IUGR neonates, with highest levels in those with abnormal neurological outcome [62].
Positive_regulation (increased) of S100B in urine
10) Confidence 0.66 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.30 Pain Relevance 0
Antidepressants stimulate the secretion of neurotrophic factors, such as brain derived neurotrophic factor (BDNF).38 Antidepressants also enhance the secretion of S100B by astrocytes via serotonergic systems.15,39-41 Interestingly, in this study, the increase in serum S100B levels in response to treatment with antidepressants was more prominent in nonresponders than in responders.
Positive_regulation (increase) of S100B in astrocytes associated with antidepressant and bdmf
11) Confidence 0.61 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.46 Pain Relevance 0.57
This may suggest that in other studies yet unknown cross-reactants were artificially increasing the apparent S100B levels measured in serum.



Positive_regulation (increasing) of S100B
12) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.59 Pain Relevance 0
There are two possible explanations that may account for the discrepancy between previous studies documenting elevated S100B levels from extracranial sources and our present findings.
Positive_regulation (elevated) of S100B
13) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.79 Pain Relevance 0.04
The controversial significance of an increased S100B immediately after surgery is indeed intriguing and it inspires further studies of the mechanisms of S100B release after cardiac surgery as well as other fields of brain damage.


Positive_regulation (increased) of S100B in brain
14) Confidence 0.61 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.07 Pain Relevance 0
13 had increased S100B levels.
Positive_regulation (increased) of S100B
15) Confidence 0.60 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 0 Pain Relevance 0
The progressive increment of S100B levels from colostrums to transition milk and mature milk demonstrates that this protein is important during the brain maturation of infants feed at breast, while in milk-formulae milks the S100B is at the lowest level reported in human milk [14], probably due to the protein epitopes modification during the production process.
Positive_regulation (increment) of S100B in colostrums
16) Confidence 0.50 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.55 Pain Relevance 0
Our study showed that an increase in fat mass might not in isolation be a major contributor to elevated S100B levels.
Positive_regulation (contributor) of S100B in fat
17) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 1.19 Pain Relevance 0.04
Thus, serum S100B levels may increase prior to a significant change in neurological function, or neuronal cell death, which is in accordance to its function as an astroglial and non-neuronal protein marker.
Spec (may) Positive_regulation (increase) of S100B in neuronal associated with death
18) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.54 Pain Relevance 0.08
One possible explanation could be that by including the S100B level at the end of CPB we compensate for some part of the contamination in the S100B levels one hour after surgery.
Positive_regulation (compensate) of S100B
19) Confidence 0.50 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0 Pain Relevance 0
Supporting previous findings [62, 63], S100B was shown to be highly elevated in sCJD with no overlap to the other groups [46].
Positive_regulation (elevated) of S100B
20) Confidence 0.49 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 1.01 Pain Relevance 0

General Comments

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