INT6436

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2010
Negated 8
Speculated 6
Reported most in Abstract
Documents 101
Total Number 107
Disease Relevance 18.71
Pain Relevance 57.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 19
neurons 15
nucleus 13
brain 10
amygdala 10
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 314 100.00 Very High Very High Very High
qutenza 264 100.00 Very High Very High Very High
Pain 177 100.00 Very High Very High Very High
Morphine 139 100.00 Very High Very High Very High
Nucleus accumbens 85 100.00 Very High Very High Very High
Inflammation 57 100.00 Very High Very High Very High
Enkephalin 55 100.00 Very High Very High Very High
nMDA receptor 44 100.00 Very High Very High Very High
narcan 39 100.00 Very High Very High Very High
agonist 30 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 157 100.00 Very High Very High Very High
Nociception 108 100.00 Very High Very High Very High
Stress 95 100.00 Very High Very High Very High
INFLAMMATION 59 100.00 Very High Very High Very High
Nervous System Injury 20 100.00 Very High Very High Very High
Injury 48 99.98 Very High Very High Very High
Depression 13 99.98 Very High Very High Very High
Drug Dependence 11 99.76 Very High Very High Very High
Neuropathic Pain 85 98.96 Very High Very High Very High
Urological Neuroanatomy 51 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found an increase in distention-induced Fos in preshocked rats in the nucleus tractus solitarius and a weaker effect in the central nucleus of the amygdala.
Positive_regulation (increase) of Positive_regulation (induced) of Fos in nucleus associated with amygdala
1) Confidence 0.70 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882806 Disease Relevance 0.29 Pain Relevance 0.12
Induction of Fos-LI in spinally transected rats with 3 days of hindpaw inflammation was significantly increased in ipsilateral lumbar (L 4,5) spinal cord, when compared with control animals with similar inflammation but an intact spinal cord.
Positive_regulation (increased) of Positive_regulation (Induction) of Fos in spinal cord associated with inflammation and spinal cord
2) Confidence 0.69 Published 1996 Journal Neuroreport Section Abstract Doc Link 8930986 Disease Relevance 0.56 Pain Relevance 0.54
Results indicated that the AA treatment induced a significant increase of both c-Fos-ir and c-fos mRNA in the PVN.
Positive_regulation (induced) of Positive_regulation (increase) of c-fos mRNA in PVN
3) Confidence 0.69 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17514764 Disease Relevance 0.07 Pain Relevance 0.19
Intracerebroventricular administration of galanin or galanin receptor subtype 1 agonist M617 induces c-Fos activation in central amygdala and dorsomedial hypothalamus.
Positive_regulation (induces) of Positive_regulation (activation) of c-Fos in amygdala associated with agonist, amygdala and intracerebroventricular
4) Confidence 0.67 Published 2007 Journal Peptides Section Title Doc Link 17337094 Disease Relevance 0.09 Pain Relevance 0.47
The MTZ induction of c-fos appears neither sufficient nor always necessary for the subsequent MTZ induction of Penk and TH gene expression.
Neg (nor) Spec (appears) Positive_regulation (necessary) of Positive_regulation (induction) of c-fos
5) Confidence 0.67 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0 Pain Relevance 0.15
Furthermore, our results indicate that CREB phosphorylation may be necessary but not sufficient for c-fos induction.
Neg (not) Spec (may) Positive_regulation (necessary) of Positive_regulation (induction) of c-fos
6) Confidence 0.67 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.33 Pain Relevance 0.68
Methadone and morphine induced activation of c-Fos protein in the terminal forebrain projecting areas of the brain dopaminergic system, i.e. the striatum and nucleus accumbens.
Positive_regulation (induced) of Positive_regulation (activation) of c-Fos in brain associated with nucleus accumbens, methadone and morphine
7) Confidence 0.67 Published 2006 Journal Pharmacol Rep Section Abstract Doc Link 16531639 Disease Relevance 0 Pain Relevance 0.64
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (increased) of Positive_regulation (activation) of c-fos associated with dopamine, agonist and intracerebroventricular
8) Confidence 0.67 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.71
Tachykinin NK1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus.
Positive_regulation (enhance) of Positive_regulation (induced) of c-fos in locus coeruleus associated with stress, analgesic, locus ceruleus and antagonist
9) Confidence 0.67 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9652329 Disease Relevance 0.35 Pain Relevance 0.64
Similarly, methamphetamine induced a different pattern of c-fos and zif/268 messenger RNA induction in sensory/motor cortex, dorsal striatum (caudatoputamen) and ventral striatum (nucleus accumbens) than did amphetamine.
Positive_regulation (induced) of Positive_regulation (induction) of c-fos in cortex associated with nucleus accumbens
10) Confidence 0.67 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477938 Disease Relevance 0.09 Pain Relevance 0.21
As compared to an acute dose of morphine in a naive animal, the induction of c-Fos was increased in the dorsolateral CPu following challenge injection at 7 days, but not at 14 days.
Positive_regulation (increased) of Positive_regulation (induction) of c-Fos in CPu associated with morphine
11) Confidence 0.67 Published 1999 Journal Brain Res. Section Abstract Doc Link 10415375 Disease Relevance 0 Pain Relevance 0.98
Our results demonstrate that blockade of brain tachykinin receptors, especially of the neurokinin-1 receptor, reduces the behavioural response to pain and the pain-induced c-Fos activation in distinct brain areas which are intimately linked with nociceptive neurotransmission and the initiation and integration of central stress responses.
Positive_regulation (induced) of Positive_regulation (activation) of c-Fos in brain associated with stress, nociception and pain
12) Confidence 0.67 Published 2000 Journal Neuroscience Section Abstract Doc Link 10670449 Disease Relevance 0.79 Pain Relevance 0.86
The stress-induced c-fos induction was markedly decreased by a moderate (10 mg/kg) dose of morphine.
Positive_regulation (induced) of Positive_regulation (induction) of c-fos associated with stress and morphine
13) Confidence 0.67 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12225868 Disease Relevance 0.67 Pain Relevance 0.76
Injection of saline also increased induction of Fos along the length of hippocampus.
Positive_regulation (increased) of Positive_regulation (induction) of Fos in hippocampus associated with hippocampus
14) Confidence 0.67 Published 2004 Journal Brain Res. Section Abstract Doc Link 15033432 Disease Relevance 0.33 Pain Relevance 0.37
In particular it has been shown that d-amphetamine can induce an activation of the c-fos early gene in various subregions of the neostriatum and that morphine treatment can antagonize this activation.
Positive_regulation (induce) of Positive_regulation (activation) of c-fos early gene associated with morphine
15) Confidence 0.66 Published 1991 Journal J. Chem. Neuroanat. Section Abstract Doc Link 1683539 Disease Relevance 0 Pain Relevance 0.43
CONCLUSION: NO mediated the increase of Fos protein and NMDA1A R mRNA expression in the rat spinal cord during morphine withdrawal.


Positive_regulation (mediated) of Positive_regulation (increase) of Fos in spinal cord
16) Confidence 0.65 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11747755 Disease Relevance 0 Pain Relevance 0
Furthermore, chronic infusion of the selective L-type Ca2+ channel antagonist, nimodipine, significantly inhibited the enhancement of Fos induction in the paraventricular and supraoptic nuclei from morphine-withdrawn animals.
Positive_regulation (enhancement) of Positive_regulation (induction) of Fos associated with antagonist and morphine
17) Confidence 0.50 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698063 Disease Relevance 0.06 Pain Relevance 1.08
These data suggest that the induction of Fos in the lumbosacral spinal cord by noxious and non-noxious CRD is partially NMDA receptor mediated.
Spec (partially) Positive_regulation (mediated) of Positive_regulation (induction) of Fos in spinal cord associated with nmda receptor and spinal cord
18) Confidence 0.50 Published 1999 Journal Pain Section Abstract Doc Link 10534605 Disease Relevance 0.09 Pain Relevance 0.37
Fos activation was increased by CoPP, detected predominantly in neuronal rather than glial cells, and was markedly more robust in the hypothalamus than in other brain areas.
Positive_regulation (increased) of Positive_regulation (activation) of Fos in hypothalamus
19) Confidence 0.50 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15059790 Disease Relevance 0.26 Pain Relevance 0.17
Results indicated that the AA treatment induced a significant increase of both c-Fos-ir and c-fos mRNA in the PVN.
Positive_regulation (induced) of Positive_regulation (increase) of c-Fos-ir in PVN
20) Confidence 0.50 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17514764 Disease Relevance 0.07 Pain Relevance 0.19

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