INT64370

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 5.19
Pain Relevance 7.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod1) nucleocytoplasmic transport (Neurod1) nucleus (Neurod1)
DNA binding (Neurod1) transcription factor binding (Neurod1) cytoplasm (Neurod1)
Anatomy Link Frequency
brain 2
sensory neurons 1
DRG 1
stem cell 1
central nervous system 1
Neurod1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 81 99.68 Very High Very High Very High
Central nervous system 7 99.68 Very High Very High Very High
sodium channel 17 99.62 Very High Very High Very High
gABA 23 99.38 Very High Very High Very High
addiction 7 98.92 Very High Very High Very High
trigeminal ganglion 150 98.76 Very High Very High Very High
lidocaine 1 98.44 Very High Very High Very High
local anesthetic 9 98.22 Very High Very High Very High
Nav1.2 2 97.96 Very High Very High Very High
allodynia 2 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 98.88 Very High Very High Very High
Ganglion Cysts 182 98.76 Very High Very High Very High
Nervous System Injury 4 98.56 Very High Very High Very High
Neuropathic Pain 3 96.80 Very High Very High Very High
Cognitive Disorder 33 95.64 Very High Very High Very High
Targeted Disruption 198 93.44 High High
Neurodegenerative Disease 153 91.68 High High
Disease 27 90.16 High High
Heart Disease 2 87.12 High High
Cv Unclassified Under Development 1 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coexpression of the beta1 and beta2 subunits modulated the properties of Scn8a channels, but to a lesser extent than for the Rat1 or Rat2 channels.
Gene_expression (Coexpression) of beta2 in Rat2
1) Confidence 0.75 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9698304 Disease Relevance 0.28 Pain Relevance 0.34
The beta 2 nAChR is most widely expressed in the central nervous system, and is involved in the functional high-affinity nicotine receptor regulating cognitive performance and the mesolimbic dopamine system.
Gene_expression (expressed) of beta 2 in central nervous system associated with cognitive disorder, dopamine, nicotine and central nervous system
2) Confidence 0.75 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803206 Disease Relevance 0.31 Pain Relevance 0.30
The effects of local anesthetics (lidocaine, bupivacaine, procaine and tetracaine) on GABA-induced currents of receptors expressing different subunit combinations (alpha1beta2, alpha1beta2gamma2s, alpha4beta2gamma2s and beta2) were examined via the two electrode voltage clamp method.
Gene_expression (expressing) of beta2 associated with gaba, lidocaine and local anesthetic
3) Confidence 0.75 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10936490 Disease Relevance 0.15 Pain Relevance 1.14
Among the various GABAA-R subunits, the alpha1, alpha4, beta2, and delta subunits are heavily expressed in thalamic relay nuclei.
Gene_expression (expressed) of beta2
4) Confidence 0.75 Published 2007 Journal Alcohol Section Abstract Doc Link 17521848 Disease Relevance 0.19 Pain Relevance 0.66
Voltage-gated sodium channel (Na(v)1) beta2 subunits modulate channel gating, assembly, and cell-surface expression in CNS neurons in vitro and in vivo. beta2 expression increases in sensory neurons after nerve injury, and development of mechanical allodynia in the spared nerve injury model is attenuated in beta2-null mice.
Gene_expression (expression) of beta2 in sensory neurons associated with nervous system injury, allodynia and sodium channel
5) Confidence 0.72 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16870743 Disease Relevance 0.74 Pain Relevance 0.69
Brn3a has previously been shown to directly repress the expression of Neurod1 and Neurod4 [14] but an activator function has, to date, only been demonstrated in cell transfection models [21,29].
Gene_expression (expression) of Neurod1
6) Confidence 0.69 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.41 Pain Relevance 0.21
These tNSCs showed neurosphere formation and expressed high levels of early neuroectodermal markers, such as the proneural genes NeuroD1, Neurog2, and Olig2, the NSC markers Nestin and Musashi1, and the proliferation markers Ki67 and BrdU (5-bromo-2-deoxyuridine).
Gene_expression (expressed) of NeuroD1
7) Confidence 0.67 Published 2006 Journal Stem Cells Section Abstract Doc Link 16373695 Disease Relevance 0.23 Pain Relevance 0.29
In transgenic mice with overexpression of the beta 2-adrenergic receptor, heart rate and mean velocity of circumferential fiber shortening were increased, indicating enhanced contractility.
Gene_expression (overexpression) of beta 2 in heart
8) Confidence 0.65 Published 1996 Journal Circulation Section Body Doc Link 8790053 Disease Relevance 0.17 Pain Relevance 0
Our results suggest that beta2 modulates TTX-S Na(v)1 mRNA and protein expression resulting in increased TTX-S I(Na) and increases the rates of TTX-S Na(v)1 activation and inactivation in small-fast DRG neurons in vivo.
Gene_expression (expression) of beta2 in DRG associated with dorsal root ganglion
9) Confidence 0.62 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16870743 Disease Relevance 0.65 Pain Relevance 0.65
Immunolabeling demonstrates the interdependence of mouse brain alpha4 and beta2 nicotinic acetylcholine receptor subunit expression.
Gene_expression (expression) of beta2 in brain
10) Confidence 0.57 Published 2006 Journal J. Comp. Neurol. Section Title Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10
Prior work has shown that Brn3a is necessary to terminate the expression of early neurogenic transcription factors such as Neurod1 and Neurod4 in the developing TG.
Gene_expression (expression) of Neurod1 associated with trigeminal ganglion
11) Confidence 0.53 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.47 Pain Relevance 0.16
In situ mRNA hybridization was also performed to determine if altered mRNA transcription mediated the interdependence of alpha4 and beta2 subunit expression. alpha4-Null mutation did not affect beta2 mRNA expression, nor did beta2 genotype affect alpha4 mRNA expression.
Gene_expression (expression) of beta2
12) Confidence 0.50 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10
In situ mRNA hybridization was also performed to determine if altered mRNA transcription mediated the interdependence of alpha4 and beta2 subunit expression. alpha4-Null mutation did not affect beta2 mRNA expression, nor did beta2 genotype affect alpha4 mRNA expression.
Gene_expression (expression) of beta2
13) Confidence 0.50 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10
-catenin is active and triggers the expression of NeuroD1 in the hippocampal neurogenic niche of mice [35]–[37].
Gene_expression (expression) of NeuroD1
14) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.65 Pain Relevance 0.03
Thus, although most beta2 subunit protein expression is alpha4-dependent, this dependence is not universal.
Gene_expression (expression) of beta2 associated with addiction
15) Confidence 0.45 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.13
Proliferating cells showed no or undetectable levels of NeuroD1 and VGLUT1.
Neg (no) Gene_expression (levels) of NeuroD1
16) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.13 Pain Relevance 0.34
Although the brain region investigated by Gaudilliere et al. was not the DG, considering the high expression of NeuroD in the hippocampus [37], it is possible that the impaired CaMKII-NeuroD pathway underlies the abnormality of DG maturation of the mutants.
Gene_expression (expression) of NeuroD in brain associated with hippocampus
17) Confidence 0.39 Published 2008 Journal Mol Brain Section Body Doc Link PMC2562999 Disease Relevance 0.05 Pain Relevance 0.05
From a Nestin-GFP-positive radial glia-like putative stem cell (type-1) development proceeds over a population of highly proliferative Nestin-GFP-positive intermediate progenitor cells with glial properties, but lacking the radial morphology (type-2a) and a similarly proliferative progenitor cell which is still Nestin-GFP-positive but also expresses DCX (as well as, for example, Prox1 and NeuroD1) and thus shows signs of neuronal determination (type-2b).
Gene_expression (expresses) of NeuroD1 in stem cell
18) Confidence 0.38 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.29 Pain Relevance 0.04
The non-proteolytic BACE1 effect on Nav1.2 current was confirmed in murine neuroblastoma cells, which express sodium channels endogenously, but lack beta2 and beta4.
Neg (lack) Gene_expression (lack) of beta2 associated with neuroblastoma, sodium channel and nav1.2
19) Confidence 0.35 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19056495 Disease Relevance 0.17 Pain Relevance 0.40
The i.v. agent etomidate exerts its anaesthetic actions through potentiation of gamma-aminobutyric acid-A receptors containing beta2 and beta3 subunits.
Gene_expression (containing) of beta2
20) Confidence 0.34 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232301 Disease Relevance 0.13 Pain Relevance 0.04

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