INT64371

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Context Info
Confidence 0.64
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.56
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod1) nucleocytoplasmic transport (Neurod1) nucleus (Neurod1)
DNA binding (Neurod1) transcription factor binding (Neurod1) cytoplasm (Neurod1)
Anatomy Link Frequency
sensory neurons 2
DRG 2
heart 2
Neurod1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 6 97.50 Very High Very High Very High
dorsal root ganglion 10 97.24 Very High Very High Very High
allodynia 2 97.20 Very High Very High Very High
addiction 3 84.16 Quite High
tetrodotoxin 6 75.00 Quite High
Pain 2 75.00 Quite High
Root ganglion neuron 2 75.00 Quite High
IPN 1 61.24 Quite High
anesthesia 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 4 98.96 Very High Very High Very High
Ganglion Cysts 12 97.24 Very High Very High Very High
Neuropathic Pain 2 97.20 Very High Very High Very High
Heart Disease 2 87.12 High High
Targeted Disruption 1 85.28 High High
Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Voltage-gated sodium channel (Na(v)1) beta2 subunits modulate channel gating, assembly, and cell-surface expression in CNS neurons in vitro and in vivo. beta2 expression increases in sensory neurons after nerve injury, and development of mechanical allodynia in the spared nerve injury model is attenuated in beta2-null mice.
Positive_regulation (increases) of Gene_expression (expression) of beta2 in sensory neurons associated with nervous system injury, allodynia and sodium channel
1) Confidence 0.64 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16870743 Disease Relevance 0.74 Pain Relevance 0.69
In transgenic mice with overexpression of the beta 2-adrenergic receptor, heart rate and mean velocity of circumferential fiber shortening were increased, indicating enhanced contractility.
Positive_regulation (overexpression) of Gene_expression (overexpression) of beta 2 in heart
2) Confidence 0.49 Published 1996 Journal Circulation Section Body Doc Link 8790053 Disease Relevance 0.17 Pain Relevance 0
Our results suggest that beta2 modulates TTX-S Na(v)1 mRNA and protein expression resulting in increased TTX-S I(Na) and increases the rates of TTX-S Na(v)1 activation and inactivation in small-fast DRG neurons in vivo.
Positive_regulation (increases) of Gene_expression (expression) of beta2 in DRG associated with dorsal root ganglion
3) Confidence 0.46 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16870743 Disease Relevance 0.65 Pain Relevance 0.66
In situ mRNA hybridization was also performed to determine if altered mRNA transcription mediated the interdependence of alpha4 and beta2 subunit expression. alpha4-Null mutation did not affect beta2 mRNA expression, nor did beta2 genotype affect alpha4 mRNA expression.
Positive_regulation (interdependence) of Gene_expression (expression) of beta2
4) Confidence 0.37 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10

General Comments

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