INT6438

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.09
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RAN) GTPase activity (RAN) cytoplasm (RAN)
cytosol (RAN) signal transduction (RAN) mitosis (RAN)
Anatomy Link Frequency
NG108-15 1
RAN (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 12 99.84 Very High Very High Very High
Delta opioid receptors 1 99.36 Very High Very High Very High
Opioid 3 98.40 Very High Very High Very High
Kappa opioid receptor 6 98.04 Very High Very High Very High
Serotonin 1 97.96 Very High Very High Very High
Enkephalin 4 90.76 High High
MU agonist 2 89.20 High High
adenocard 1 83.24 Quite High
opioid receptor 4 75.32 Quite High
antagonist 1 68.12 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 4 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 99.80 Very High Very High Very High
Bordatella Infection 2 97.08 Very High Very High Very High
Neuroblastoma 1 96.24 Very High Very High Very High
Glioma 1 95.68 Very High Very High Very High
Infection 3 92.92 High High
Genetic Predisposition To Disease 1 88.32 High High
Rhabdomyolysis 1 84.60 Quite High
Disorder Of Lipid Metabolism 2 78.68 Quite High
Dyslipidemia /

Combined Dyslipidemia

5 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN).
Positive_regulation (restricting) of RAN associated with opioid, serotonin and eating disorder
1) Confidence 0.42 Published 2007 Journal Biol. Psychiatry Section Abstract Doc Link 16806108 Disease Relevance 0.44 Pain Relevance 0.15
Critically requiring G alpha q-protein function, this effect is located downstream of guanosine diphosphate-guanosine triphosphate exchange and is not dependent on increased guanosine triphosphatase activity, phosphatases, or protein kinases.


Neg (not) Positive_regulation (dependent) of guanosine triphosphatase
2) Confidence 0.10 Published 2004 Journal Anesthesiology Section Body Doc Link 15087620 Disease Relevance 0 Pain Relevance 0
Critically requiring G alpha q-protein function, this effect is located downstream of guanosine diphosphate-guanosine triphosphate exchange and is not dependent on increased guanosine triphosphatase activity, phosphatases, or protein kinases.


Positive_regulation (increased) of guanosine triphosphatase
3) Confidence 0.07 Published 2004 Journal Anesthesiology Section Body Doc Link 15087620 Disease Relevance 0 Pain Relevance 0
Rho-guanosine triphosphatase (GTPase) activity is required for HIV infectivity into the cells [145].
Positive_regulation (required) of Rho-guanosine triphosphatase associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.05 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.20 Pain Relevance 0
The extent of stimulation of low Km guanosine-triphosphatase (GTPase activity) and inhibition of hormonally-stimulated cAMP accumulation in the NG108-15 (neuroblastoma-glioma) hybrid cell line were determined and compared for six closely related peptides.
Positive_regulation (stimulation) of Km guanosine-triphosphatase in NG108-15 associated with neuroblastoma and glioma
5) Confidence 0.02 Published 1992 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1328097 Disease Relevance 0.19 Pain Relevance 0.29
Cellular guanosine triphosphatase activity was significantly increased by naloxone in the cells expressing the mu- and kappa-opioid receptors, which suggests that the application of naloxone to these receptors induces activation of the G proteins.
Positive_regulation (increased) of Cellular guanosine triphosphatase associated with kappa opioid receptor and narcan
6) Confidence 0.01 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9706949 Disease Relevance 0.19 Pain Relevance 1.15

General Comments

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