INT6441

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 98
Total Number 104
Disease Relevance 57.22
Pain Relevance 24.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
plasma 16
CSF 7
joint 4
pituitary 4
cervix 4
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 67 99.98 Very High Very High Very High
Central nervous system 28 99.94 Very High Very High Very High
Fibrositis 173 99.80 Very High Very High Very High
narcan 78 99.80 Very High Very High Very High
dexamethasone 33 99.72 Very High Very High Very High
Opioid 96 99.68 Very High Very High Very High
amygdala 46 99.68 Very High Very High Very High
Morphine 12 99.54 Very High Very High Very High
palliative 11 99.46 Very High Very High Very High
addiction 119 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 825 100.00 Very High Very High Very High
Pulmonary Disease 132 100.00 Very High Very High Very High
Heart Failure 124 100.00 Very High Very High Very High
Chronic Renal Failure 117 100.00 Very High Very High Very High
Schizophrenia 511 99.84 Very High Very High Very High
Fibromyalgia 119 99.80 Very High Very High Very High
Congenital Anomalies 60 99.68 Very High Very High Very High
Premature Birth 874 99.60 Very High Very High Very High
Reprotox - General 2 4 99.48 Very High Very High Very High
Osteoarthritis 74 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of CRH gene promoter activity is similar in Neuro-2A cells, both intact and differentiated, and in AtT-20 cell line, and cAMP/PKA-dependent pathway plays an important role in the stimulation of CRH gene.
Positive_regulation (stimulation) of CRH gene in AtT-20
1) Confidence 0.69 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.13 Pain Relevance 0.36
Although yohimbine robustly increased CSF NE levels and appeared to increase CSF CRH levels, these effects were not seen after naloxone or placebo administration.
Spec (appeared) Positive_regulation (increase) of CSF CRH in CSF associated with narcan
2) Confidence 0.69 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11095445 Disease Relevance 0.14 Pain Relevance 0.44
Extrapolation of these concepts suggests that elevated CRH may be related to anxiety, depression, or other disorders associated with chronic stress responses.
Positive_regulation (elevated) of CRH associated with stress, depression and anxiety disorder
3) Confidence 0.69 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC544567 Disease Relevance 0.68 Pain Relevance 0.20
RNase protection assays demonstrated increased levels of CRH-reporter transcripts in stably transfected cells after treatment with cAMP and potassium, with the induced transcripts initiating at the major transcription initiation site of the human CRH gene.
Positive_regulation (increased) of CRH-reporter
4) Confidence 0.69 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8182084 Disease Relevance 0 Pain Relevance 0.05
Activation of brain corticotropin-releasing factor (CRF) receptors mediates stress-related inhibition of upper GI and stimulation of lower GI motor function through interaction with different CRF receptor subtypes.
Positive_regulation (Activation) of CRF in brain associated with stress
5) Confidence 0.67 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11208537 Disease Relevance 0.34 Pain Relevance 0.11
In previous primate studies, in comparison to predictably reared controls, monkeys exposed as infants to maternal variable foraging demand (VFD) rearing exhibited persistent elevations of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF), as well as other biological disturbances.
Positive_regulation (elevations) of CRF in CSF
6) Confidence 0.67 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 10963795 Disease Relevance 0.09 Pain Relevance 0.50
In previous primate studies, in comparison to predictably reared controls, monkeys exposed as infants to maternal variable foraging demand (VFD) rearing exhibited persistent elevations of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF), as well as other biological disturbances.
Positive_regulation (elevations) of corticotropin-releasing factor in CSF
7) Confidence 0.67 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 10963795 Disease Relevance 0.09 Pain Relevance 0.50
Chronic maternal distress compromises the normal regulation of hormonal activity during pregnancy and elevates free circulating corticotrophin-releasing hormone (CRH), probably of placental origin, before the normal increase occurs at term.
Spec (probably) Positive_regulation (elevates) of CRH
8) Confidence 0.67 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15944068 Disease Relevance 0.47 Pain Relevance 0.12
Gestational stress also increases CRH activity in the amygdala and the incidence of anxiogenic and depressive-like behavior in rats and non-human primates, which can be ameliorated by CRH antagonists.
Positive_regulation (increases) of CRH in amygdala associated with stress, depression, antagonist and amygdala
9) Confidence 0.67 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15944068 Disease Relevance 0.71 Pain Relevance 0.24
There were significantly higher levels of CRH-R1 mRNA in PTnotL cervix than in TnotL (p = 0.02) (Figure 1B).
Positive_regulation (levels) of CRH in cervix
10) Confidence 0.67 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.14 Pain Relevance 0
We suggest that the disruptive effect of stress on reproductive function in the women could be, at least in part, dependent on decreased gonadotropin secretion induced by elevated endogenous CRH levels.
Positive_regulation (elevated) of CRH associated with stress
11) Confidence 0.66 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2493035 Disease Relevance 0.10 Pain Relevance 0.36
On the other hand, estrogen directly stimulates the CRH gene promoter and the central noradrenergic system [50], which may explain women's mood cycles and manifestations of autoimmune/allergic and inflammatory diseases that follow estradiol fluctuations.


Positive_regulation (stimulates) of CRH associated with inflammation, hypersensitivity and disease
12) Confidence 0.59 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 1.53 Pain Relevance 0.09
Low maternal warmth has been shown to predict faster relapse in bipolar disorder (Geller et al 2004) and comparative studies suggest that, compared with other forms of childhood trauma, emotional abuse and neglect may be greater predictors of adult psychopathology (Brown et al 2005), monoamine system dysregulation (Roy 2002) and increased CSF CRH (Lee et al 2005).
Positive_regulation (increased) of CSF CRH associated with manic depressive disorder, injury, increased venous pressure under development, recurrence and monoamine
13) Confidence 0.57 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.83 Pain Relevance 0.05
Another factor is childhood trauma, which is associated with sensitization of the stress response, glucocorticoid resistance, increased CRH activity, immune activation and reduced hippocampal volume (Heim et al., 2008).
Positive_regulation (increased) of CRH associated with stress and injury
14) Confidence 0.51 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 1.04 Pain Relevance 0.03
The myometrial actions of CRH are mediated via a wide network of specific G-protein coupled membrane-bound receptors.
Positive_regulation (mediated) of CRH
15) Confidence 0.50 Published 2007 Journal Front. Biosci. Section Abstract Doc Link 17127317 Disease Relevance 0.18 Pain Relevance 0.18
PS rats have higher levels of CRH in the amygdala, fewer hippocampal glucocorticoid receptors and less endogenous opioid and GABA/BDZ (benzodiazepine) inhibitory activity.
Positive_regulation (levels) of CRH in amygdala associated with gaba, endogenous opioid and amygdala
16) Confidence 0.50 Published 1997 Journal Neurosci Biobehav Rev Section Abstract Doc Link 8994205 Disease Relevance 0.38 Pain Relevance 0.22
Several functional studies documented that peripheral injection of CRF or urocortin stimulates colonic transit, motility, Fos expression in myenteric neurons, and defecation through activation of CRF(1) receptors, whereas it decreases ileal contractility via CRF(2) receptors.
Positive_regulation (activation) of CRF in neurons
17) Confidence 0.50 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20388944 Disease Relevance 0.45 Pain Relevance 0.07
Corticotropin-releasing hormone (CRH) has been implicated as an important mediator of stress-induced abnormalities in intestinal mucosal function in animal models, but to date no studies in human colon have been reported.
Positive_regulation (mediator) of CRH in colon associated with stress and congenital anomalies
18) Confidence 0.50 Published 2008 Journal Gut Section Abstract Doc Link 17525093 Disease Relevance 0.49 Pain Relevance 0.10
Clinical data indicate that dysfunctions of the stress response system, expressed as excessive CRF activity and possible hyperstimulation of CRF(1) receptors, are present in a range of stress-related disorders, including depression, anxiety, and irritable bowel syndrome.
Spec (possible) Positive_regulation (hyperstimulation) of CRF in bowel associated with stress, depression, spastic colon and anxiety disorder
19) Confidence 0.49 Published 2007 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 17511614 Disease Relevance 1.43 Pain Relevance 0.29
Effects of CRF are probably mediated by the opioid system.
Positive_regulation (mediated) of CRF associated with opioid
20) Confidence 0.49 Published 1993 Journal Environ Health Perspect Section Abstract Doc Link PMC1519927 Disease Relevance 1.25 Pain Relevance 0.19

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