INT64436

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 93
Total Number 93
Disease Relevance 32.69
Pain Relevance 36.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
C8-B4 9
neurons 8
microglia 6
macrophages 5
Lamina 4
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 266 100.00 Very High Very High Very High
antagonist 188 100.00 Very High Very High Very High
Analgesic 9 100.00 Very High Very High Very High
primary afferent fibers 117 99.98 Very High Very High Very High
Dorsal horn 412 99.96 Very High Very High Very High
Peripheral nerve injury 16 99.96 Very High Very High Very High
antidepressant 420 99.92 Very High Very High Very High
dorsal root ganglion 92 99.84 Very High Very High Very High
trigeminal ganglion 303 99.82 Very High Very High Very High
Glutamate receptor 29 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 329 100.00 Very High Very High Very High
Nervous System Injury 47 99.96 Very High Very High Very High
Ganglion Cysts 500 99.82 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

7 99.68 Very High Very High Very High
Injury 47 99.52 Very High Very High Very High
INFLAMMATION 120 98.96 Very High Very High Very High
Cancer Pain 8 98.96 Very High Very High Very High
Neuropathic Pain 256 98.72 Very High Very High Very High
Breast Cancer 2 98.68 Very High Very High Very High
Pain 258 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that minodronic acid inhibited alpha,beta-methylene ATP-induced cation uptake with the potency higher than that of suramin in the P2X(2/3) receptor receptor-expressing cells.
Gene_expression (expressing) of P2X associated with potency
1) Confidence 0.78 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18565509 Disease Relevance 0.34 Pain Relevance 0.27
The P2X(3) receptor was expressed in about 40% of peripherin-positive small and medium-sized neurons in the dorsal root ganglia.
Gene_expression (expressed) of P2X in neurons
2) Confidence 0.78 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.14 Pain Relevance 0.44
These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.
Gene_expression (expression) of P2X in skin associated with cancer pain
3) Confidence 0.78 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.09 Pain Relevance 0.38
In the somatosensory system, P2X receptors are expressed on both peripheral and central terminals of primary afferent neurons.
Gene_expression (expressed) of P2X in afferent neurons
4) Confidence 0.77 Published 2003 Journal Neuroscientist Section Abstract Doc Link 14580121 Disease Relevance 0.14 Pain Relevance 0.24
The quantification of P2X mRNA expression in dorsal root ganglion (DRG) provides important information for neuropathic pain studies.
Gene_expression (expression) of P2X mRNA in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and neuropathic pain
5) Confidence 0.75 Published 2002 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 12431708 Disease Relevance 0.27 Pain Relevance 0.18
Furthermore, 86% of the UTP-sensitive C fibers and 100% of the UTP-sensitive AM fibers also responded to the P2X agonist alpha,beta-methylene ATP, indicating that P2Y and P2X receptors are widely co-expressed.
Gene_expression (co-expressed) of P2X associated with agonist
6) Confidence 0.75 Published 2004 Journal Pain Section Abstract Doc Link 15082124 Disease Relevance 0.26 Pain Relevance 0.71
This process is mediated via changes in the expression and function of P2X(3) receptors initially through enhanced trafficking and, later, perhaps through augmented synthesis of P2X(3) receptors.
Gene_expression (expression) of P2X
7) Confidence 0.75 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.52 Pain Relevance 0.65
Thus, neurons of the mouse trigeminal subnucleus caudalis substantia gelatinosa exhibit N-type and P/Q-type voltage-gated calcium channels, and receive presynaptic afferents that express TRPV1 and P2X(2/3) receptors.
Gene_expression (express) of P2X in neurons associated with substantia gelatinosa and calcium channel
8) Confidence 0.75 Published 2009 Journal Pain Section Abstract Doc Link 19703729 Disease Relevance 0 Pain Relevance 0.45
The present data indicate a novel mechanism for enhancing P2X(3) receptor expression and function in trigeminal sensory neurons by CGRP via CREB phosphorylation.
Gene_expression (expression) of P2X in sensory neurons associated with calcitonin gene-related peptide
9) Confidence 0.75 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.07 Pain Relevance 0.43
The P2X(7) purinoceptor is a ligand-gated cation channel, expressed predominantly by cells of immune origin, with a unique phenotype which includes release of biologically active inflammatory cytokine, interleukin (IL)-1beta following activation, and unique ion channel biophysics observed only in this receptor family.
Gene_expression (expressed) of P2X associated with inflammation and cytokine
10) Confidence 0.75 Published 2005 Journal Pain Section Abstract Doc Link 15777864 Disease Relevance 0.58 Pain Relevance 0.25
Preceding intramuscular administration of the P2X receptor antagonist PPADS (3-100 nmol/l) suppressed the ATP effect.
Gene_expression (administration) of P2X receptor associated with antagonist
11) Confidence 0.67 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16686909 Disease Relevance 0.41 Pain Relevance 0.28
P2X and P2Y nucleotide receptors are described on sensory neurons and their peripheral and central terminals in dorsal root, nodose, trigeminal, petrosal, retinal and enteric ganglia.
Gene_expression (described) of P2X in dorsal root
12) Confidence 0.67 Published 2009 Journal Handb Exp Pharmacol Section Abstract Doc Link 19655112 Disease Relevance 0.25 Pain Relevance 0.08
Those expressed on peripheral terminals are activated in response to both nociceptive and innocuous stimuli, whereas those at central terminals ("central terminal P2X receptors") play an important role in modulating sensory transmission to the spinal cord dorsal horn.
Gene_expression (expressed) of P2X in spinal cord dorsal horn associated with nociception, dorsal horn and spinal cord
13) Confidence 0.67 Published 2003 Journal Neuroscientist Section Abstract Doc Link 14580121 Disease Relevance 0.18 Pain Relevance 0.35
Here, we demonstrate that in response to peripheral nerve injury, P2X(4) receptors (P2X(4)R) are expressed de novo by activated microglia in the spinal cord.
Gene_expression (expressed) of P2X in peripheral nerve associated with nervous system injury, spinal cord and peripheral nerve injury
14) Confidence 0.66 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.67 Pain Relevance 0.70
Here, we demonstrate that in response to peripheral nerve injury, P2X(4) receptors (P2X(4)R) are expressed de novo by activated microglia in the spinal cord.
Gene_expression (expressed) of P2X in peripheral nerve associated with nervous system injury, spinal cord and peripheral nerve injury
15) Confidence 0.66 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.66 Pain Relevance 0.70
ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including glial cells in the central nervous system.
Gene_expression (localized) of P2X in central nervous system associated with central nervous system
16) Confidence 0.65 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16982702 Disease Relevance 0.35 Pain Relevance 0.34
Increased P2X(3) receptor synthesis was partly mediated by endogenous brain-derived neurotrophic factor (BDNF) because of its block by anti-BDNF antibodies and mimicry by exogenous BDNF.
Gene_expression (synthesis) of P2X in brain
17) Confidence 0.65 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.37 Pain Relevance 0.62
This process is mediated via changes in the expression and function of P2X(3) receptors initially through enhanced trafficking and, later, perhaps through augmented synthesis of P2X(3) receptors.
Gene_expression (synthesis) of P2X
18) Confidence 0.65 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.51 Pain Relevance 0.64
Our results suggest that in mouse stomach are present muscular P2Y receptors, subserving relaxation, and neuronal presynaptic P2X receptors, mediating contraction.
Gene_expression (presynaptic) of P2X in neuronal
19) Confidence 0.60 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15878718 Disease Relevance 0 Pain Relevance 0.19
P2X receptors: targets for novel analgesics?
Gene_expression (targets) of P2X associated with analgesic
20) Confidence 0.60 Published 2005 Journal Neuroscientist Section Title Doc Link 16061521 Disease Relevance 0.51 Pain Relevance 0.85

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