INT64437

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.22
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1R1) plasma membrane (IL1R1) intracellular (IL1R1)
signal transducer activity (IL1R1)
IL1R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 48 99.96 Very High Very High Very High
Inflammation 198 98.60 Very High Very High Very High
Fibrositis 54 98.40 Very High Very High Very High
cytokine 84 96.08 Very High Very High Very High
Intracerebroventricular 3 95.08 Very High Very High Very High
Pain 14 92.28 High High
spastic colon 1 90.12 High High
Neurotransmitter 1 88.16 High High
Potency 1 85.96 High High
Inflammatory marker 10 81.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 231 98.60 Very High Very High Very High
Fibromyalgia 54 98.40 Very High Very High Very High
Acute Coronary Syndrome 126 97.28 Very High Very High Very High
Hyperplasia 1 96.12 Very High Very High Very High
Coronary Artery Disease 21 95.56 Very High Very High Very High
Myalgia 1 92.80 High High
Pain 11 92.28 High High
Fever 1 91.76 High High
Fatigue 3 91.48 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The filter paper was transferred to a buffer solution, and IL-1 beta and IL-1ra were assessed using ELISA.
Gene_expression (assessed) of IL-1ra
1) Confidence 0.65 Published 1996 Journal Dig. Dis. Sci. Section Abstract Doc Link 8794793 Disease Relevance 0.60 Pain Relevance 0.28
In a subset of 20 patients, production of interleukin 1 alpha (IL-1 alpha), interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and IL-1 receptor antagonist (IL-1ra) at the mRNA and protein levels was determined using in situ hybridization with biotin labeled ribo-probes and immunohistochemistry.
Spec (determined) Gene_expression (production) of IL-1ra
2) Confidence 0.65 Published 1997 Journal J. Rheumatol. Section Body Doc Link 9034998 Disease Relevance 0.16 Pain Relevance 0
In addition, increased levels of IL-1Ra and IL-6 have been found in the supernatants of cells from FM patients in vitro stimulation and cellular proliferation studies [7].
Gene_expression (levels) of IL-1Ra associated with fibrositis and hyperplasia
3) Confidence 0.58 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 2.18 Pain Relevance 1.02
Interestingly, its receptor (IL-1R) has a peak expression at 6~7 hours post stimulation, while IL-1A expression has reached another peak in about 8~9 hours.
Gene_expression (expression) of IL-1R
4) Confidence 0.55 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.35 Pain Relevance 0.24
It is not surprising that the current movement toward evidence-based medicine based on this kind of evidence is predominantly I-It in nature.
Neg (not) Gene_expression (surprising) of I-It
5) Confidence 0.29 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2733137 Disease Relevance 0.15 Pain Relevance 0
IL-1 and IL-1ra are expressed in diseased human coronary arteries [8,9].
Gene_expression (expressed) of IL-1
6) Confidence 0.22 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 1.07 Pain Relevance 0.42
We believe that there are plausible links between IL-1 activation and these markers.
Gene_expression (activation) of IL-1
7) Confidence 0.19 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.77 Pain Relevance 0.16
Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study)

Background

Gene_expression (effect) of Interleukin-1 receptor associated with acute coronary syndrome, inflammation and antagonist
8) Confidence 0.19 Published 2008 Journal Trials Section Title Doc Link PMC2289802 Disease Relevance 0.84 Pain Relevance 0.31
IL-1ra infusion was initiated 1 h before IL-1 and extended over the experimental period.
Gene_expression (infusion) of IL-1
9) Confidence 0.19 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10601814 Disease Relevance 0 Pain Relevance 0.55
The aspirated volume of synovialfluid (SFV) was recorded and levels of prostaglandin (PG) E2, transforming growth factor beta-1, tumor necrosis factor alpha, interleukin I receptor antagonist, chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate were measured.
Gene_expression (levels) of interleukin I receptor
10) Confidence 0.04 Published 2001 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11491492 Disease Relevance 0 Pain Relevance 0

General Comments

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