INT64441

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Context Info
Confidence 0.27
First Reported 1996
Last Reported 2004
Negated 3
Speculated 3
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 2.93
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
dorsal root ganglia 3
tegmentum 3
sciatic nerve 2
amygdala 2
substantia nigra 1
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 23 100.00 Very High Very High Very High
Sciatic nerve 6 99.84 Very High Very High Very High
Spinal cord 3 99.68 Very High Very High Very High
amygdala 5 98.96 Very High Very High Very High
tolerance 11 98.24 Very High Very High Very High
Pain 6 97.56 Very High Very High Very High
Ventral tegmentum 2 96.08 Very High Very High Very High
Substantia nigra 2 95.36 Very High Very High Very High
Opioid 2 94.80 High High
Analgesic 5 93.60 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 99.52 Very High Very High Very High
Urological Neuroanatomy 4 98.08 Very High Very High Very High
Neuropathic Pain 15 97.88 Very High Very High Very High
Pain 3 97.56 Very High Very High Very High
Injury 3 91.68 High High
Drug Dependence 2 80.24 Quite High
Opiate Addiction 4 75.00 Quite High
Ganglion Cysts 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings prompted us to investigate the changes in MC4-R mRNA level in the spinal cord and dorsal root ganglia (DRG) of neuropathic animals at different time points after sciatic nerve injury by quantitative real-time PCR.
Spec (investigate) Regulation (changes) of Spec (investigate) Transcription (level) of MC4-R in dorsal root ganglia associated with nervous system injury, neuropathic pain, sciatic nerve and spinal cord
1) Confidence 0.27 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.73 Pain Relevance 0.43
In contrast, morphine administration did not influence levels of MC4-R mRNA in several other brain regions, including frontal cortex, olfactory bulb, hypothalamus, and ventral tegmentum/substantia nigra.
Neg (not) Regulation (influence) of Transcription (levels) of MC4-R in tegmentum associated with ventral tegmentum, substantia nigra, urological neuroanatomy and morphine
2) Confidence 0.27 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.34 Pain Relevance 1.15
In the present study, we investigated the effect of acute and chronic morphine administration on the level of CRF1 and melanocortin 4 receptor (MC4-R) mRNAs in the rat amygdala by quantitative real-time PCR method.
Spec (investigated) Regulation (effect) of Transcription (level) of melanocortin 4 receptor in amygdala associated with amygdala and morphine
3) Confidence 0.24 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.03
The spinal MC4-R mRNA level was not affected by sciatic nerve injury.
Neg (not) Regulation (affected) of Transcription (level) of MC4-R in sciatic nerve associated with nervous system injury and sciatic nerve
4) Confidence 0.24 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.79 Pain Relevance 0.44
These findings prompted us to investigate the changes in MC4-R mRNA level in the spinal cord and dorsal root ganglia (DRG) of neuropathic animals at different time points after sciatic nerve injury by quantitative real-time PCR.
Spec (investigate) Regulation (changes) of in spinal cord Spec (investigate) Transcription (level) of MC4-R in dorsal root ganglia associated with nervous system injury, neuropathic pain, sciatic nerve and spinal cord
5) Confidence 0.09 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.73 Pain Relevance 0.43
In contrast, morphine administration did not influence levels of MC4-R mRNA in several other brain regions, including frontal cortex, olfactory bulb, hypothalamus, and ventral tegmentum/substantia nigra.
Neg (not) Regulation (influence) of in substantia nigra Transcription (levels) of MC4-R in tegmentum associated with ventral tegmentum, substantia nigra, urological neuroanatomy and morphine
6) Confidence 0.09 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.34 Pain Relevance 1.15

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