INT64442

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2009
Negated 3
Speculated 8
Reported most in Abstract
Documents 6
Total Number 15
Disease Relevance 5.22
Pain Relevance 19.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
spinal cord 3
dorsal root ganglia 3
amygdala 3
spinal 1
substantia nigra 1
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 121 100.00 Very High Very High Very High
opioid receptor 12 100.00 Very High Very High Very High
Sciatic nerve 8 99.84 Very High Very High Very High
Pain 15 99.38 Very High Very High Very High
Spinal cord 15 99.24 Very High Very High Very High
amygdala 15 99.24 Very High Very High Very High
withdrawal 12 98.68 Very High Very High Very High
tolerance 63 98.24 Very High Very High Very High
Hyperalgesia 5 98.24 Very High Very High Very High
Eae 10 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Non-diabetic Peripheral Neuropathy 2 99.60 Very High Very High Very High
Nervous System Injury 6 99.52 Very High Very High Very High
Nociception 2 99.24 Very High Very High Very High
Hyperalgesia 7 98.24 Very High Very High Very High
Urological Neuroanatomy 4 98.08 Very High Very High Very High
Injury 15 98.00 Very High Very High Very High
Pain 9 97.56 Very High Very High Very High
Neuropathic Pain 25 97.44 Very High Very High Very High
Drug Dependence 2 80.24 Quite High
Opiate Addiction 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the impact of supraspinal MC4 receptors (MC4 R) modulation on this phenomenon and morphine withdrawal hyperalgesia remained unexplored.
Regulation (modulation) of MC4 R associated with hyperalgesia, withdrawal and morphine
1) Confidence 0.62 Published 2007 Journal Brain Res. Section Abstract Doc Link 17915196 Disease Relevance 0.26 Pain Relevance 1.43
We examined also the influence of chronic morphine administration on mu-opioid receptor (MOR) and melanocortin 4 receptor (MC4-R) mRNAs in the rat spinal cord and dorsal root ganglia (DRG) during morphine tolerance.
Spec (examined) Regulation (influence) of MC4-R in dorsal root ganglia associated with tolerance, opioid receptor, spinal cord and morphine
2) Confidence 0.59 Published 2005 Journal Pain Section Abstract Doc Link 16153779 Disease Relevance 0 Pain Relevance 2.17
We examined also the influence of chronic morphine administration on mu-opioid receptor (MOR) and melanocortin 4 receptor (MC4-R) mRNAs in the rat spinal cord and dorsal root ganglia (DRG) during morphine tolerance.
Spec (examined) Regulation (influence) of melanocortin 4 receptor in dorsal root ganglia associated with tolerance, opioid receptor, spinal cord and morphine
3) Confidence 0.59 Published 2005 Journal Pain Section Abstract Doc Link 16153779 Disease Relevance 0 Pain Relevance 2.16
The spinal MC4-R mRNA level was not affected by sciatic nerve injury.
Neg (not) Regulation (affected) of MC4-R in sciatic nerve associated with nervous system injury and sciatic nerve
4) Confidence 0.54 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.79 Pain Relevance 0.44
This up-regulation of MC4 receptors promotes the pronociceptive action of their endogenous ligands.
Regulation (regulation) of MC4
5) Confidence 0.44 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 20081244 Disease Relevance 0.97 Pain Relevance 1.06
Together, painful neuropathy resulted in the up-regulation of MC4 receptors in the spinal and peripheral nociceptive pathways.
Regulation (regulation) of MC4 in spinal associated with nociception and pain
6) Confidence 0.44 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 20081244 Disease Relevance 1.06 Pain Relevance 1.14
These findings prompted us to investigate the changes in MC4-R mRNA level in the spinal cord and dorsal root ganglia (DRG) of neuropathic animals at different time points after sciatic nerve injury by quantitative real-time PCR.
Spec (investigate) Regulation (changes) of MC4-R in dorsal root ganglia associated with nervous system injury, neuropathic pain, sciatic nerve and spinal cord
7) Confidence 0.27 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.73 Pain Relevance 0.43
In contrast, morphine administration did not influence levels of MC4-R mRNA in several other brain regions, including frontal cortex, olfactory bulb, hypothalamus, and ventral tegmentum/substantia nigra.
Neg (not) Regulation (influence) of MC4-R in tegmentum associated with ventral tegmentum, substantia nigra, urological neuroanatomy and morphine
8) Confidence 0.27 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.34 Pain Relevance 1.15
In the present study, we investigated the effect of acute and chronic morphine administration on the level of CRF1 and melanocortin 4 receptor (MC4-R) mRNAs in the rat amygdala by quantitative real-time PCR method.
Spec (investigated) Regulation (effect) of MC4-R in amygdala associated with amygdala and morphine
9) Confidence 0.24 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.03
The effect of morphine on MC4 and CRF receptor mRNAs in the rat amygdala and attenuation of tolerance after their blockade.
Regulation (effect) of MC4 in amygdala associated with tolerance, amygdala and morphine
10) Confidence 0.24 Published 2003 Journal Brain Res. Section Title Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.15
In the present study, we investigated the effect of acute and chronic morphine administration on the level of CRF1 and melanocortin 4 receptor (MC4-R) mRNAs in the rat amygdala by quantitative real-time PCR method.
Spec (investigated) Regulation (effect) of melanocortin 4 receptor in amygdala associated with amygdala and morphine
11) Confidence 0.24 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.03
We examined also the influence of chronic morphine administration on mu-opioid receptor (MOR) and melanocortin 4 receptor (MC4-R) mRNAs in the rat spinal cord and dorsal root ganglia (DRG) during morphine tolerance.
Spec (examined) Regulation (influence) of melanocortin 4 receptor in spinal cord associated with tolerance, opioid receptor, spinal cord and morphine
12) Confidence 0.20 Published 2005 Journal Pain Section Abstract Doc Link 16153779 Disease Relevance 0 Pain Relevance 2.16
We examined also the influence of chronic morphine administration on mu-opioid receptor (MOR) and melanocortin 4 receptor (MC4-R) mRNAs in the rat spinal cord and dorsal root ganglia (DRG) during morphine tolerance.
Spec (examined) Regulation (influence) of MC4-R in spinal cord associated with tolerance, opioid receptor, spinal cord and morphine
13) Confidence 0.20 Published 2005 Journal Pain Section Abstract Doc Link 16153779 Disease Relevance 0 Pain Relevance 2.17
These findings prompted us to investigate the changes in MC4-R mRNA level in the spinal cord and dorsal root ganglia (DRG) of neuropathic animals at different time points after sciatic nerve injury by quantitative real-time PCR.
Spec (investigate) Regulation (changes) of MC4-R in spinal cord associated with nervous system injury, neuropathic pain, sciatic nerve and spinal cord
14) Confidence 0.09 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.73 Pain Relevance 0.43
In contrast, morphine administration did not influence levels of MC4-R mRNA in several other brain regions, including frontal cortex, olfactory bulb, hypothalamus, and ventral tegmentum/substantia nigra.
Neg (not) Regulation (influence) of MC4-R in substantia nigra associated with ventral tegmentum, substantia nigra, urological neuroanatomy and morphine
15) Confidence 0.09 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.34 Pain Relevance 1.15

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