INT64444

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 5.12
Pain Relevance 6.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
DRG 3
striatum 1
amygdala 1
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 15 100.00 Very High Very High Very High
Pain 12 100.00 Very High Very High Very High
Morphine 19 99.68 Very High Very High Very High
amygdala 5 99.32 Very High Very High Very High
antidepressant 3 99.12 Very High Very High Very High
Sciatic nerve 7 98.92 Very High Very High Very High
Neuropathic pain 9 98.40 Very High Very High Very High
withdrawal 1 97.36 Very High Very High Very High
anesthesia 1 97.24 Very High Very High Very High
depression 5 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 100.00 Very High Very High Very High
Neuropathic Pain 22 99.84 Very High Very High Very High
Anxiety Disorder 7 99.76 Very High Very High Very High
Injury 9 99.24 Very High Very High Very High
Nervous System Injury 6 99.20 Very High Very High Very High
Depression 5 97.04 Very High Very High Very High
Pain 8 96.56 Very High Very High Very High
Stress 4 95.92 Very High Very High Very High
Nociception 1 95.04 Very High Very High Very High
Urological Neuroanatomy 2 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent development of selective antagonists for the MC4R has provided pharmacological evidence that blockade of MC4R could be a useful way of alleviating numerous conditions such as anxiety/depression, pain, and addiction to drugs of abuse.
Negative_regulation (blockade) of MC4R associated with addiction, pain, depression, antagonist and anxiety disorder
1) Confidence 0.58 Published 2005 Journal Peptides Section Abstract Doc Link 15979204 Disease Relevance 0.54 Pain Relevance 0.32
Therefore, a block of the MC4 receptors results in the antagonism of neuropathic pain and such treatment could be beneficial therapeutically for individuals with chronic neuropathic pain.
Negative_regulation (block) of MC4 associated with neuropathic pain
2) Confidence 0.57 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 20081244 Disease Relevance 1.12 Pain Relevance 1.05
Our study demonstrated that acute morphine administration decreased the level of MC4-R mRNA in the rat amygdala.
Negative_regulation (decreased) of MC4-R in amygdala associated with amygdala and morphine
3) Confidence 0.52 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.55
In contrast, down-regulation of MC4-R mRNA in DRG developed 2 weeks after the injury and was parallel with the attenuated effectiveness of MC4-R ligands in neuropathic animals.
Negative_regulation (regulation) of MC4-R in DRG associated with neuropathic pain and injury
4) Confidence 0.43 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.80 Pain Relevance 0.43
Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats.
Negative_regulation (down-regulated) of Melanocortin 4 receptor in dorsal root ganglions associated with ganglion cysts, pain and neuropathic pain
5) Confidence 0.43 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15026153 Disease Relevance 0.76 Pain Relevance 0.53
In contrast, down-regulation of MC4-R mRNA in DRG developed 2 weeks after the injury and was parallel with the attenuated effectiveness of MC4-R ligands in neuropathic animals.
Negative_regulation (effectiveness) of MC4-R in DRG associated with neuropathic pain and injury
6) Confidence 0.38 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.80 Pain Relevance 0.42
Subsequent modification of JK1 yielded compound Ac-Nle-Gly-Lys-D-Nal(2)-Arg-Trp-Gly-NH(2) (JK7)(,) a selective MC4R antagonist with 34-fold MC4R/MC3R and 109-fold MC4R/MC5R selectivity.
Negative_regulation (antagonist) of MC4R associated with antagonist
7) Confidence 0.38 Published 2003 Journal Peptides Section Abstract Doc Link 12668212 Disease Relevance 0.22 Pain Relevance 0.21
In the striatum, the reduction of MC4-R mRNA was accompanied by a concomitant decrease in melanocortin receptor levels, shown by quantitative radioligand binding and autoradiography.
Negative_regulation (reduction) of MC4-R in striatum
8) Confidence 0.37 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.36 Pain Relevance 1.20
The medium of cells transfected with flAgRP vector, containing the endogenous AgRP signal peptide, also inhibited the MC4R.
Negative_regulation (inhibited) of MC4R
9) Confidence 0.24 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.09
The difference in potency between VWF-AgRP83-132 and flAgRP to antagonize NDP-MSH, 0.5 versus 1.4 nM respectively, is in the range which we expected, since a study by Creemers et. al. showed that AgRP83-132 was 6.1 fold more potent than flAgRP in inhibiting the MC4R [22].
Negative_regulation (inhibiting) of MC4R associated with potency
10) Confidence 0.20 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.05
These observations indicate that MCL0129 is a potent and selective MC4 antagonist with anxiolytic- and antidepressant-like activities in various rodent models.
Spec (like) Negative_regulation (antagonist) of MC4 associated with antidepressant, antagonist and anxiety disorder
11) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538838 Disease Relevance 0.52 Pain Relevance 0.59

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