INT64445

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 5.06
Pain Relevance 12.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
DRG 3
hypothalamus 2
nucleus accumbens 2
striatum 2
central nervous system 2
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
Central grey 7 99.92 Very High Very High Very High
Morphine 42 99.68 Very High Very High Very High
Central nervous system 2 99.68 Very High Very High Very High
opioid receptor 4 99.66 Very High Very High Very High
Spinal cord 5 99.28 Very High Very High Very High
antagonist 18 99.24 Very High Very High Very High
fluoxetine 5 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 99.92 Very High Very High Very High
Ganglion Cysts 1 99.20 Very High Very High Very High
Opiate Addiction 14 98.76 Very High Very High Very High
Drug Dependence 7 98.44 Very High Very High Very High
Neuropathic Pain 10 97.92 Very High Very High Very High
Injury 7 95.52 Very High Very High Very High
Stress 5 91.60 High High
Depression 7 90.32 High High
Pain 7 90.16 High High
Anxiety Disorder 9 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats.
Gene_expression (expressed) of Melanocortin 4 receptor in dorsal root ganglions associated with ganglion cysts, pain and neuropathic pain
1) Confidence 0.78 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15026153 Disease Relevance 0.74 Pain Relevance 0.52
The melanocortin-4 receptor (MC4R), which is predominantly expressed in the central nervous system, has in particular become the focus of much attention in recent years because of the critical roles it plays in a wide range of functions, including feeding, sexual behavior, and stress.
Gene_expression (expressed) of MC4R in central nervous system associated with stress and central nervous system
2) Confidence 0.77 Published 2005 Journal Peptides Section Abstract Doc Link 15979204 Disease Relevance 0.24 Pain Relevance 0.26
The melanocortin-4 receptor (MC4R), which is predominantly expressed in the central nervous system, has in particular become the focus of much attention in recent years because of the critical roles it plays in a wide range of functions, including feeding, sexual behavior, and stress.
Gene_expression (expressed) of melanocortin-4 receptor in central nervous system associated with stress and central nervous system
3) Confidence 0.77 Published 2005 Journal Peptides Section Abstract Doc Link 15979204 Disease Relevance 0.24 Pain Relevance 0.26
In light of previous findings that melanocortins antagonize opiate self-administration, analgesic tolerance, and physical dependence, we hypothesize that decreased melanocortin function, via down-regulation of MC4-R expression, may contribute to the development of these opiate-induced behaviors.
Gene_expression (expression) of MC4-R associated with physical dependence, analgesic, tolerance and opiate
4) Confidence 0.77 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.33 Pain Relevance 1.05
Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction.
Gene_expression (expression) of melanocortin-4 receptor in brain associated with addiction, opiate and morphine
5) Confidence 0.77 Published 1996 Journal Mol. Pharmacol. Section Title Doc Link 8794897 Disease Relevance 0.25 Pain Relevance 0.85
In addition, we assess the expression of MC4 receptors in the spinal cord and the DRG of rats subjected to neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve.
Gene_expression (expression) of MC4 in DRG associated with eae, injury, neuropathic pain, sciatic nerve and spinal cord
6) Confidence 0.75 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 20081244 Disease Relevance 0.67 Pain Relevance 0.88
Chronic administration of morphine (5 days) resulted in a time-dependent down-regulation of MC4-R mRNA expression in the striatum and periaqueductal gray.
Gene_expression (expression) of MC4-R in striatum associated with central grey and morphine
7) Confidence 0.67 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.30 Pain Relevance 0.97
Expression of MC4-R mRNA was found to be enriched in the striatum, nucleus accumbens, and periaque-ductal gray, all of which are regions implicated in the behavioral effects of opiates.
Gene_expression (Expression) of MC4-R in nucleus accumbens associated with nucleus accumbens and opiate
8) Confidence 0.67 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.22 Pain Relevance 0.82
Expression of MC4-R mRNA was also decreased in the nucleus accumbens/ olfactory tubercle, but this effect was observed after 1 or 3 days of morphine treatment.
Gene_expression (Expression) of MC4-R in olfactory tubercle associated with nucleus accumbens and morphine
9) Confidence 0.67 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.30 Pain Relevance 1.08
Fluoxetine administration increased POMC expression and reduced MC4-R expression in the hypothalamus, without changes in AgRP mRNA levels.
Gene_expression (expression) of MC4-R in hypothalamus associated with fluoxetine
10) Confidence 0.58 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359080 Disease Relevance 0.40 Pain Relevance 0.44
Using RT-PCR we demonstrated no changes in the spinal cord but there was a decrease in MOR and increase in MC4-R gene expression in the DRG of rats tolerant to morphine.
Gene_expression (expression) of MC4-R in DRG associated with opioid receptor, morphine and spinal cord
11) Confidence 0.57 Published 2005 Journal Pain Section Abstract Doc Link 16153779 Disease Relevance 0 Pain Relevance 2.24
The present study examined the interrelationships between feeding responses produced by mu opioid receptor agonists and melanocortin-3 or 4 (MC-3/4) receptor antagonists.
Gene_expression (produced) of melanocortin-3 or 4 associated with antagonist, agonist and mu opioid receptor
12) Confidence 0.34 Published 2003 Journal Brain Res. Section Abstract Doc Link 14575897 Disease Relevance 0.07 Pain Relevance 0.51
Forskolin directly activates adenylyl cyclase, thereby increasing cAMP (control for transfection of MC4R and CRE-LacZ).
Gene_expression (transfection) of MC4R
13) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.07
Melanotan II (MTII) is a synthetic MC3R and MC4R agonist which reduces food intake when given intracerebroventricularly (ICV) and into the PVN.
Gene_expression (synthetic) of MC4R in PVN associated with agonist
14) Confidence 0.25 Published 2009 Journal Physiol. Behav. Section Abstract Doc Link 19136019 Disease Relevance 0.15 Pain Relevance 0.64
Expression of MC4-R mRNA was found to be enriched in the striatum, nucleus accumbens, and periaque-ductal gray, all of which are regions implicated in the behavioral effects of opiates.
Gene_expression (Expression) of MC4-R in striatum associated with nucleus accumbens and opiate
15) Confidence 0.23 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.22 Pain Relevance 0.82
Expression of MC4-R mRNA was also decreased in the nucleus accumbens/ olfactory tubercle, but this effect was observed after 1 or 3 days of morphine treatment.
Gene_expression (Expression) of MC4-R in nucleus accumbens associated with nucleus accumbens and morphine
16) Confidence 0.23 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.30 Pain Relevance 1.08
Addition of NDP-MSH to MC4R and CRE-LacZ transfected cells resulted in a dose response curve with an EC50 value of 0.1 nM (1 × 10-10).
Gene_expression (transfected) of MC4R
17) Confidence 0.15 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.11
MCL0129 attenuated the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4 receptor, whereas MCL0129 did not affect basal cAMP levels, thereby indicating that MCL0129 acts as an antagonist at the MC4 receptor.
Gene_expression (expressing) of MC4 associated with antagonist
18) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538838 Disease Relevance 0.62 Pain Relevance 0.32

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