INT64446

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.01
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
olfactory tubercle 3
striatum 2
amygdala 2
nucleus accumbens 1
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 3 99.92 Very High Very High Very High
Morphine 27 99.68 Very High Very High Very High
Nucleus accumbens 6 99.68 Very High Very High Very High
amygdala 5 99.32 Very High Very High Very High
withdrawal 1 97.36 Very High Very High Very High
tail-flick 1 96.60 Very High Very High Very High
tolerance 13 95.92 Very High Very High Very High
opiate 18 92.68 High High
antagonist 2 88.64 High High
Potency 3 77.12 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 99.92 Very High Very High Very High
Opiate Addiction 6 75.00 Quite High
Drug Dependence 3 50.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MC4-R mRNA was also decreased in the nucleus accumbens/ olfactory tubercle, but this effect was observed after 1 or 3 days of morphine treatment.
Negative_regulation (decreased) of Transcription (Expression) of MC4-R in olfactory tubercle associated with nucleus accumbens and morphine
1) Confidence 0.43 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.35 Pain Relevance 1.14
Chronic administration of morphine (5 days) resulted in a time-dependent down-regulation of MC4-R mRNA expression in the striatum and periaqueductal gray.
Negative_regulation (down-regulation) of Transcription (expression) of MC4-R in striatum associated with central grey and morphine
2) Confidence 0.43 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.30 Pain Relevance 0.97
Our study demonstrated that acute morphine administration decreased the level of MC4-R mRNA in the rat amygdala.
Negative_regulation (decreased) of Transcription (level) of MC4-R in amygdala associated with amygdala and morphine
3) Confidence 0.38 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.55
Expression of MC4-R mRNA was also decreased in the nucleus accumbens/ olfactory tubercle, but this effect was observed after 1 or 3 days of morphine treatment.
Negative_regulation (decreased) of in nucleus accumbens Transcription (Expression) of MC4-R in olfactory tubercle associated with nucleus accumbens and morphine
4) Confidence 0.15 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.35 Pain Relevance 1.14

General Comments

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