INT64447

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Context Info
Confidence 0.61
First Reported 1996
Last Reported 2004
Negated 0
Speculated 2
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 6.08
Pain Relevance 15.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
amygdala 3
spinal cord 2
striatum 2
nucleus accumbens 2
dorsal root ganglia 2
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 7 99.92 Very High Very High Very High
Spinal cord 13 99.68 Very High Very High Very High
Morphine 88 99.54 Very High Very High Very High
amygdala 20 99.32 Very High Very High Very High
Sciatic nerve 6 99.16 Very High Very High Very High
Nucleus accumbens 14 98.72 Very High Very High Very High
Pain 8 97.12 Very High Very High Very High
withdrawal 4 96.80 Very High Very High Very High
Ventral tegmentum 7 96.08 Very High Very High Very High
tail-flick 4 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 99.92 Very High Very High Very High
Nervous System Injury 6 98.84 Very High Very High Very High
Neuropathic Pain 25 97.88 Very High Very High Very High
Pain 7 97.12 Very High Very High Very High
Injury 5 90.32 High High
Hyperalgesia 6 86.64 High High
Nociception 6 80.88 Quite High
Drug Dependence 7 80.24 Quite High
Opiate Addiction 14 80.16 Quite High
Ganglion Cysts 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This decrease was attenuated following chronic morphine administration, and mRNA level of MC4 receptors was gradually increased and, on 9th day of morphine administration, i.e. in the period when morphine tolerance already developed, the level was significantly increased in comparison with control and with the effect after single morphine dose.
Transcription (level) of MC4 associated with tolerance and morphine
1) Confidence 0.61 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.65
These findings prompted us to investigate the changes in MC4-R mRNA level in the spinal cord and dorsal root ganglia (DRG) of neuropathic animals at different time points after sciatic nerve injury by quantitative real-time PCR.
Spec (investigate) Transcription (level) of MC4-R in dorsal root ganglia associated with nervous system injury, neuropathic pain, sciatic nerve and spinal cord
2) Confidence 0.53 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.73 Pain Relevance 0.43
Expression of MC4-R mRNA was found to be enriched in the striatum, nucleus accumbens, and periaque-ductal gray, all of which are regions implicated in the behavioral effects of opiates.
Transcription (Expression) of MC4-R in nucleus accumbens associated with nucleus accumbens and opiate
3) Confidence 0.53 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.22 Pain Relevance 0.82
Expression of MC4-R mRNA was also decreased in the nucleus accumbens/ olfactory tubercle, but this effect was observed after 1 or 3 days of morphine treatment.
Transcription (Expression) of MC4-R in olfactory tubercle associated with nucleus accumbens and morphine
4) Confidence 0.53 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.30 Pain Relevance 1.08
In contrast, morphine administration did not influence levels of MC4-R mRNA in several other brain regions, including frontal cortex, olfactory bulb, hypothalamus, and ventral tegmentum/substantia nigra.
Transcription (levels) of MC4-R in tegmentum associated with ventral tegmentum, substantia nigra, urological neuroanatomy and morphine
5) Confidence 0.53 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.34 Pain Relevance 1.14
Chronic administration of morphine (5 days) resulted in a time-dependent down-regulation of MC4-R mRNA expression in the striatum and periaqueductal gray.
Transcription (expression) of MC4-R in striatum associated with central grey and morphine
6) Confidence 0.53 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.30 Pain Relevance 0.97
In the present study, we investigated the effect of acute and chronic morphine administration on the level of CRF1 and melanocortin 4 receptor (MC4-R) mRNAs in the rat amygdala by quantitative real-time PCR method.
Transcription (level) of MC4-R in amygdala associated with amygdala and morphine
7) Confidence 0.47 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.02
Our study demonstrated that acute morphine administration decreased the level of MC4-R mRNA in the rat amygdala.
Transcription (level) of MC4-R in amygdala associated with amygdala and morphine
8) Confidence 0.47 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.55
In the present study, we investigated the effect of acute and chronic morphine administration on the level of CRF1 and melanocortin 4 receptor (MC4-R) mRNAs in the rat amygdala by quantitative real-time PCR method.
Transcription (level) of melanocortin 4 receptor in amygdala associated with amygdala and morphine
9) Confidence 0.47 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.02
The spinal MC4-R mRNA level was not affected by sciatic nerve injury.
Transcription (level) of MC4-R in sciatic nerve associated with nervous system injury and sciatic nerve
10) Confidence 0.47 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.79 Pain Relevance 0.43
These findings prompted us to investigate the changes in MC4-R mRNA level in the spinal cord and dorsal root ganglia (DRG) of neuropathic animals at different time points after sciatic nerve injury by quantitative real-time PCR.
Spec (investigate) Transcription (level) of MC4-R in spinal cord associated with nervous system injury, neuropathic pain, sciatic nerve and spinal cord
11) Confidence 0.18 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15026153 Disease Relevance 0.73 Pain Relevance 0.43
Expression of MC4-R mRNA was also decreased in the nucleus accumbens/ olfactory tubercle, but this effect was observed after 1 or 3 days of morphine treatment.
Transcription (Expression) of MC4-R in nucleus accumbens associated with nucleus accumbens and morphine
12) Confidence 0.18 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.30 Pain Relevance 1.08
In contrast, morphine administration did not influence levels of MC4-R mRNA in several other brain regions, including frontal cortex, olfactory bulb, hypothalamus, and ventral tegmentum/substantia nigra.
Transcription (levels) of MC4-R in substantia nigra associated with ventral tegmentum, substantia nigra, urological neuroanatomy and morphine
13) Confidence 0.18 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.34 Pain Relevance 1.14
Expression of MC4-R mRNA was found to be enriched in the striatum, nucleus accumbens, and periaque-ductal gray, all of which are regions implicated in the behavioral effects of opiates.
Transcription (Expression) of MC4-R in striatum associated with nucleus accumbens and opiate
14) Confidence 0.18 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.22 Pain Relevance 0.82
MC4 receptor, proopiomelanocortin (POMC) and agouti-related protein (AgRP) transcripts were detected in both spinal cord and DRG, whereas MC3 receptor was detected only in the spinal cord.
Transcription (detected) of MC4 in spinal cord associated with spinal cord
15) Confidence 0.14 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.90 Pain Relevance 0.85
MC4 receptor, proopiomelanocortin (POMC) and agouti-related protein (AgRP) transcripts were detected in both spinal cord and DRG, whereas MC3 receptor was detected only in the spinal cord.
Transcription (detected) of MC4 in DRG associated with spinal cord
16) Confidence 0.05 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.90 Pain Relevance 0.85

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