INT64448

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Context Info
Confidence 0.74
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.27
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
spinal cord 2
PVN 1
brain 1
DRG 1
outer medulla 1
Mc3r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 15 99.64 Very High Very High Very High
agonist 8 99.60 Very High Very High Very High
opiate 6 99.16 Very High Very High Very High
Thermal hyperalgesia 6 96.36 Very High Very High Very High
Brush evoked pain 6 95.36 Very High Very High Very High
Nucleus accumbens 3 95.16 Very High Very High Very High
Lasting pain 3 93.76 High High
Morphine 4 93.12 High High
Eae 3 91.84 High High
Neuropathic pain 2 90.16 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 17 99.70 Very High Very High Very High
Hyperalgesia 9 96.36 Very High Very High Very High
Pain 6 93.76 High High
Injury 5 91.84 High High
Urological Neuroanatomy 2 84.48 Quite High
Body Weight 1 84.20 Quite High
Nociception 9 75.36 Quite High
Opiate Addiction 2 75.00 Quite High
Appetite Loss 2 75.00 Quite High
Cv Unclassified Under Development 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We describe here the development and evaluation of new melanocortin compounds that are selective for the MC4R as compared with the other centrally expressed receptors, MC3R and MC5R.
Gene_expression (expressed) of MC3R
1) Confidence 0.74 Published 2003 Journal Peptides Section Abstract Doc Link 12668212 Disease Relevance 0.17 Pain Relevance 0.12
CONCLUSIONS: The present study demonstrated novel renal expression of MC-1R and MC-3R, especially in the outer medulla, representative of the renal I/R injury.
Gene_expression (expression) of MC-3R in outer medulla
2) Confidence 0.72 Published 2008 Journal Transplant. Proc. Section Body Doc Link 18790174 Disease Relevance 0 Pain Relevance 0
Western blotting analyses and immunohistochemistry were employed to determine expression of MC-1R and MC-3R.
Spec (determine) Gene_expression (expression) of MC-3R
3) Confidence 0.72 Published 2008 Journal Transplant. Proc. Section Body Doc Link 18790174 Disease Relevance 0 Pain Relevance 0
Melanotan II (MTII) is a synthetic MC3R and MC4R agonist which reduces food intake when given intracerebroventricularly (ICV) and into the PVN.
Gene_expression (synthetic) of MC3R in PVN associated with agonist
4) Confidence 0.58 Published 2009 Journal Physiol. Behav. Section Abstract Doc Link 19136019 Disease Relevance 0.15 Pain Relevance 0.61
MC4 and POMC transcript were upregulated in the spinal cord of neuropathic rats, whereas MC3 and AgRP expression were unaffected.
Gene_expression (expression) of MC3 in spinal cord associated with neuropathic pain and spinal cord
5) Confidence 0.07 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.90 Pain Relevance 0.98
MC4 receptor, proopiomelanocortin (POMC) and agouti-related protein (AgRP) transcripts were detected in both spinal cord and DRG, whereas MC3 receptor was detected only in the spinal cord.
Gene_expression (detected) of MC3 in spinal cord associated with spinal cord
6) Confidence 0.06 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.91 Pain Relevance 0.85
MC4 receptor, proopiomelanocortin (POMC) and agouti-related protein (AgRP) transcripts were detected in both spinal cord and DRG, whereas MC3 receptor was detected only in the spinal cord.
Gene_expression (detected) of MC3 in DRG associated with spinal cord
7) Confidence 0.02 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.91 Pain Relevance 0.85
In contrast, MC1-, MC3-, and MC5-R are expressed at very low or undetectable levels in these brain regions.
Gene_expression (expressed) of MC3 in brain
8) Confidence 0.01 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.23 Pain Relevance 0.90

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