INT64449

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.00
Pain Relevance 7.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
olfactory tubercle 3
hypothalamus 2
striatum 2
brain 2
DRG 2
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 3 100.00 Very High Very High Very High
Morphine 34 99.98 Very High Very High Very High
Central grey 5 99.92 Very High Very High Very High
Nucleus accumbens 10 99.68 Very High Very High Very High
Spinal cord 2 99.66 Very High Very High Very High
fluoxetine 5 99.08 Very High Very High Very High
Physical dependence 5 98.82 Very High Very High Very High
opiate 31 98.76 Very High Very High Very High
addiction 10 98.48 Very High Very High Very High
tolerance 18 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 99.92 Very High Very High Very High
Drug Dependence 5 98.82 Very High Very High Very High
Opiate Addiction 10 98.76 Very High Very High Very High
Aids-related Complex 1 85.28 High High
Obesity 3 82.40 Quite High
Appetite Loss 2 78.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In light of previous findings that melanocortins antagonize opiate self-administration, analgesic tolerance, and physical dependence, we hypothesize that decreased melanocortin function, via down-regulation of MC4-R expression, may contribute to the development of these opiate-induced behaviors.
Negative_regulation (down-regulation) of Gene_expression (expression) of MC4-R associated with physical dependence, analgesic, tolerance and opiate
1) Confidence 0.58 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.33 Pain Relevance 1.06
Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction.
Negative_regulation (down-regulates) of Gene_expression (expression) of melanocortin-4 receptor in brain associated with addiction, opiate and morphine
2) Confidence 0.58 Published 1996 Journal Mol. Pharmacol. Section Title Doc Link 8794897 Disease Relevance 0.25 Pain Relevance 0.85
Expression of MC4-R mRNA was also decreased in the nucleus accumbens/ olfactory tubercle, but this effect was observed after 1 or 3 days of morphine treatment.
Negative_regulation (decreased) of Gene_expression (Expression) of MC4-R in olfactory tubercle associated with nucleus accumbens and morphine
3) Confidence 0.42 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.35 Pain Relevance 1.14
Chronic administration of morphine (5 days) resulted in a time-dependent down-regulation of MC4-R mRNA expression in the striatum and periaqueductal gray.
Negative_regulation (down-regulation) of Gene_expression (expression) of MC4-R in striatum associated with central grey and morphine
4) Confidence 0.42 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.30 Pain Relevance 0.97
Fluoxetine administration increased POMC expression and reduced MC4-R expression in the hypothalamus, without changes in AgRP mRNA levels.
Negative_regulation (reduced) of Gene_expression (expression) of MC4-R in hypothalamus associated with fluoxetine
5) Confidence 0.41 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359080 Disease Relevance 0.40 Pain Relevance 0.44
Using RT-PCR we demonstrated no changes in the spinal cord but there was a decrease in MOR and increase in MC4-R gene expression in the DRG of rats tolerant to morphine.
Negative_regulation (decrease) of Gene_expression (expression) of MC4-R in DRG associated with opioid receptor, morphine and spinal cord
6) Confidence 0.41 Published 2005 Journal Pain Section Abstract Doc Link 16153779 Disease Relevance 0 Pain Relevance 2.27
Expression of MC4-R mRNA was also decreased in the nucleus accumbens/ olfactory tubercle, but this effect was observed after 1 or 3 days of morphine treatment.
Negative_regulation (decreased) of in nucleus accumbens Gene_expression (Expression) of MC4-R in olfactory tubercle associated with nucleus accumbens and morphine
7) Confidence 0.14 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.35 Pain Relevance 1.14

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