INT64450

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 18
Disease Relevance 9.22
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Mc1r)
Anatomy Link Frequency
podocytes 4
hair follicles 2
skin 2
pigmentation 2
hearts 2
Mc1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 51 100.00 Very High Very High Very High
opiate 6 99.40 Very High Very High Very High
agonist 24 96.72 Very High Very High Very High
Nucleus accumbens 2 95.40 Very High Very High Very High
Morphine 4 93.12 High High
Central grey 1 84.48 Quite High
Potency 1 83.84 Quite High
cytokine 8 81.04 Quite High
addiction 2 75.00 Quite High
tolerance 2 72.76 Quite High
Disease Link Frequency Relevance Heat
Proteinuria 25 99.64 Very High Very High Very High
Stress 10 99.04 Very High Very High Very High
Melanoma 9 98.84 Very High Very High Very High
Skin Cancer 16 97.48 Very High Very High Very High
Cancer 3 96.96 Very High Very High Very High
Membranous Glomerulonephritis 30 95.76 Very High Very High Very High
Sunburn 2 94.64 High High
Body Weight 8 93.20 High High
Disorder Of Lipid Metabolism 5 92.96 High High
Cutaneous Melanoma 3 87.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Podocytes expressed most MC1R protein, which colocalized with synaptopodin but not with an endothelial-specific lectin.
Gene_expression (expressed) of MC1R in Podocytes
1) Confidence 0.77 Published 2010 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 20507942 Disease Relevance 1.04 Pain Relevance 0.19
In summary, podocytes express MC1R, and MC1R agonism reduces proteinuria, improves glomerular morphology, and reduces oxidative stress in nephrotic rats with PHN.
Gene_expression (express) of MC1R in podocytes associated with stress, membranous glomerulonephritis and proteinuria
2) Confidence 0.77 Published 2010 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 20507942 Disease Relevance 1.22 Pain Relevance 0.25
Here, we identified gene expression of the melanocortin receptor MC1R in podocytes, glomerular endothelial cells, mesangial cells, and tubular epithelial cells.
Gene_expression (expression) of MC1R in epithelial cells
3) Confidence 0.77 Published 2010 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 20507942 Disease Relevance 0.83 Pain Relevance 0.18
CONCLUSIONS: The present study demonstrated novel renal expression of MC-1R and MC-3R, especially in the outer medulla, representative of the renal I/R injury.
Gene_expression (expression) of MC-1R in outer medulla
4) Confidence 0.71 Published 2008 Journal Transplant. Proc. Section Body Doc Link 18790174 Disease Relevance 0 Pain Relevance 0
Western blotting analyses and immunohistochemistry were employed to determine expression of MC-1R and MC-3R.
Spec (determine) Gene_expression (expression) of MC-1R
5) Confidence 0.71 Published 2008 Journal Transplant. Proc. Section Body Doc Link 18790174 Disease Relevance 0 Pain Relevance 0
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Gene_expression (expression) of melanocortin-1 receptor in skin associated with melanocortin 1 receptor
6) Confidence 0.70 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.25
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Gene_expression (expression) of MC1R in skin associated with melanocortin 1 receptor
7) Confidence 0.70 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.25
In summary, podocytes express MC1R, and MC1R agonism reduces proteinuria, improves glomerular morphology, and reduces oxidative stress in nephrotic rats with PHN.
Gene_expression (agonism) of MC1R in podocytes associated with stress, membranous glomerulonephritis and proteinuria
8) Confidence 0.67 Published 2010 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 20507942 Disease Relevance 1.22 Pain Relevance 0.25
Western blot analysis showed that rat hearts expressed melanocortin 1 receptor (MC1R) protein.
Gene_expression (expressed) of melanocortin 1 receptor in hearts associated with melanocortin 1 receptor
9) Confidence 0.66 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.07 Pain Relevance 0.21
Melanocortin 1 receptor (MC1R), a Gs protein-coupled receptor expressed in melanocytes, is a major determinant of skin pigmentation, phototype and cancer risk.
Gene_expression (expressed) of MC1R in pigmentation associated with melanocortin 1 receptor and cancer
10) Confidence 0.59 Published 2009 Journal FEBS Lett. Section Abstract Doc Link 19755124 Disease Relevance 0.32 Pain Relevance 0.54
Melanocortin 1 receptor (MC1R), a Gs protein-coupled receptor expressed in melanocytes, is a major determinant of skin pigmentation, phototype and cancer risk.
Gene_expression (expressed) of Melanocortin 1 receptor in pigmentation associated with melanocortin 1 receptor and cancer
11) Confidence 0.59 Published 2009 Journal FEBS Lett. Section Abstract Doc Link 19755124 Disease Relevance 0.32 Pain Relevance 0.54
In summary, podocytes express MC1R, and MC1R agonism reduces proteinuria, improves glomerular morphology, and reduces oxidative stress in nephrotic rats with PHN.
Gene_expression (agonism) of MC1R in podocytes associated with stress, membranous glomerulonephritis and proteinuria
12) Confidence 0.58 Published 2010 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 20507942 Disease Relevance 1.22 Pain Relevance 0.25
Western blot analysis showed that rat hearts expressed melanocortin 1 receptor (MC1R) protein.
Gene_expression (expressed) of MC1R in hearts associated with melanocortin 1 receptor
13) Confidence 0.57 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.07 Pain Relevance 0.21
The presence of the melanocortin 1 receptor gene variant Asp84Glu appeared to impose the highest risk for cutaneous melanoma with odds ratios of 16.1 (95% CI 2.3-139.0) and 8.1 (95% CI 1.2-55.9) in compound heterozygotes and heterozygotes, respectively.
Gene_expression (presence) of melanocortin 1 receptor associated with melanocortin 1 receptor and skin cancer
14) Confidence 0.41 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11511307 Disease Relevance 0.59 Pain Relevance 0.64
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Gene_expression (expression) of melanocortin-1 receptor in hair follicles associated with melanocortin 1 receptor
15) Confidence 0.24 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.25
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Gene_expression (expression) of MC1R in hair follicles associated with melanocortin 1 receptor
16) Confidence 0.24 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.25
Melanomas collected from 123 Australian patients were analyzed for melanocortin-1 receptor (MC1R) variants and mutations in the BRAF and NRAS genes.
Gene_expression (variants) of melanocortin-1 receptor associated with melanocortin 1 receptor and melanoma
17) Confidence 0.11 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 19571821 Disease Relevance 1.09 Pain Relevance 0.26
In contrast, MC1-, MC3-, and MC5-R are expressed at very low or undetectable levels in these brain regions.
Gene_expression (expressed) of MC1 in brain
18) Confidence 0.02 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794897 Disease Relevance 0.23 Pain Relevance 0.90

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