INT64473

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.61
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
T lymphocyte 6
macrophage 2
lymphocytes 2
Th2 cells 2
helper T cells 2
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 415 100.00 Very High Very High Very High
rheumatoid arthritis 166 100.00 Very High Very High Very High
agonist 84 100.00 Very High Very High Very High
fortral 3 98.10 Very High Very High Very High
Endocannabinoid 18 92.20 High High
Inflammation 359 90.60 High High
cINOD 14 88.48 High High
Acupuncture 56 87.36 High High
chemokine 88 87.20 High High
methotrexate 12 85.16 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 166 100.00 Very High Very High Very High
Cancer 150 99.58 Very High Very High Very High
Prostate Cancer 51 98.94 Very High Very High Very High
Asthma 970 97.24 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 222 96.24 Very High Very High Very High
INFLAMMATION 405 90.60 High High
Eosinophilia 58 77.60 Quite High
Herpes Simplex Virus 2 76.96 Quite High
Hyperplasia 27 75.00 Quite High
Disease 143 73.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, the present data provide clear evidence for concentration-dependent effects of beta-adrenoceptor agonists on the IL-4 and IFN-gamma production by human PBMC.
Regulation (effects) of Gene_expression (production) of IL-4 in PBMC associated with agonist
1) Confidence 0.58 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0 Pain Relevance 0.29
In contrast, no significant effect of salmeterol (10(-11)-10(-5) M) on IL-4 production could be detected after 96 h.
Neg (no) Regulation (effect) of Gene_expression (production) of IL-4
2) Confidence 0.58 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.07 Pain Relevance 0.16
A U-shaped concentration response curve was observed for the effect of all agonists on IL-4 production 24 h after PHA activation.
Regulation (effect) of Gene_expression (production) of IL-4 associated with agonist
3) Confidence 0.58 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.08 Pain Relevance 0.13
We have found, that pentazocine, SKF 10 047, dextrorphan reduce spontaneous secretion of IL-8, IL-6 and IL-10 and selectively changes synthesis of IL-4 by Jurkat human T lymphocyte cells lines.
Regulation (changes) of Gene_expression (synthesis) of IL-4 in T lymphocyte associated with fortral
4) Confidence 0.54 Published 2005 Journal Georgian Med News Section Abstract Doc Link 16308450 Disease Relevance 0.08 Pain Relevance 0.32
production of CD4+ T cells in RA patients by IL-7 alone, by IL-4 alone or by IL-7 and IL-4 was not significantly different from healthy controls (Fig. 3, left panel).
Neg (not) Regulation (different) of Gene_expression (production) of IL-4 in T cells associated with rheumatoid arthritis
5) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.64 Pain Relevance 0.32
production by IL-7 and IL-4 was significantly different from IL-7 alone, but not statistically different from IL-4 alone.
Neg (not) Regulation (different) of Gene_expression (production) of IL-4
6) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.29 Pain Relevance 0.15
Pitrakinra is a recombinant IL-4 variant that competitively antagonises the IL-4R?
Regulation (recombinant) of Gene_expression (variant) of IL-4
7) Confidence 0.26 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 0.15 Pain Relevance 0.03
Since memory cells are less dependent on such costimulation to produce IL-4, in particular the development of naive CD4+ T cells towards Th2 cells may be disturbed in RA patients.
Regulation (dependent) of Gene_expression (produce) of IL-4 in Th2 cells associated with rheumatoid arthritis
8) Confidence 0.22 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.85 Pain Relevance 0.49
However, each variation pattern was different; the levels of IL-4 and IFN-?
Regulation (different) of Gene_expression (levels) of IL-4
9) Confidence 0.20 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.33
and increased levels of IL-4, IL-5, and IL-10, an effect that is thought to be mediated by decreasing IL-12 production thereby suggesting that ?
Regulation (effect) of Gene_expression (levels) of IL-4
10) Confidence 0.19 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.58 Pain Relevance 0.54
In vitro cyclosporin A inhibit allergen-driven T-cell proliferation, production of IL-2, IL-4, and IL-5 by human CD4+ helper T cells, and IL-5 production in PBMCs from allergen-sensitized atopic asthmatic individuals at physiologic concentrations.
Regulation (proliferation) of Gene_expression (production) of IL-4 in helper T cells associated with asthma
11) Confidence 0.19 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.76 Pain Relevance 0.23
The effects of c-MAF appear to be fairly selective, since in vitro studies have demonstrated that this factor is critical for the production of IL-4, but not for IL-5 or IL-13 [129,130]. c-Maf expression in T lymphocytes is regulated by IL-4 levels during Th differentiation.
Regulation (regulated) of Gene_expression (production) of IL-4 in T lymphocytes
12) Confidence 0.12 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.51 Pain Relevance 0
The present data motivate studies designed to determine how IL-4 regulates FAAH in prostate cancer cells compared to lymphocytes, whether stromal IL-4 immunoreactivity (and/or expression of IL-4 receptors in the tumour epithelia) correlates with tumour epithelial FAAH-IR in prostate cancer tissue, and which other components of the tumour microenvironment are potential regulators of the endocannabinoid system.



Regulation (immunoreactivity) of Gene_expression (expression) of IL-4 in lymphocytes associated with endocannabinoid, cancer and prostate cancer
13) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.90 Pain Relevance 0.05
These results suggest that vaccines consisting of tumor cells engineered to produce the type-2 cytokine IL-4 critically depend on type-1 immunity for their observed therapeutic efficacy.
Regulation (depend) of Gene_expression (produce) of IL-4 associated with cancer and cytokine
14) Confidence 0.10 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 1.09 Pain Relevance 0.23
In some of the patients the level of cytokine production remained essentially unchanged (e.g., patient no. 8, all four cytokines) and in one patient there was a drop of IL-2 and IL-4 production (patient no. 1) and in another patient the drop of INF?
Regulation (drop) of Gene_expression (production) of IL-4 associated with cytokine
15) Confidence 0.09 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0 Pain Relevance 0.35
Overall, the inappropriate Th2 responses and IL-4 production, coupled with ineffective macrophage activation, suggest that a failure in pathogen recognition and clearance could set the stage for paradoxical IRIS by promoting antigen persistence.
Regulation (responses) of Gene_expression (production) of IL-4 in macrophage associated with immune reconstitution inflammatory syndrome
16) Confidence 0.03 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 0.38 Pain Relevance 0
The levels of other cytokines such as IL-2, IL-4, IL-12, IL-13, IL-17, IFN-?
Regulation (levels) of Gene_expression (cytokines) of IL-4 associated with cytokine
17) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.23 Pain Relevance 0.35

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