INT64480

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Context Info
Confidence 0.33
First Reported 1996
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 0.23
Pain Relevance 4.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC) extracellular region (PNOC) plasma membrane (OPRL1)
signal transducer activity (OPRL1)
Anatomy Link Frequency
brain 1
OPRL1 (Homo sapiens)
PNOC (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 62 100.00 Very High Very High Very High
opioid receptor 32 99.96 Very High Very High Very High
narcan 4 98.08 Very High Very High Very High
Morphine 4 97.88 Very High Very High Very High
Dynorphin 4 93.28 High High
antagonist 4 91.72 High High
agonist 4 91.44 High High
Opioid 3 75.20 Quite High
tail-flick 1 75.20 Quite High
Neuropeptide 1 70.16 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 79.08 Quite High
Hyperalgesia 1 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Na+ increased the Kd of nociceptin binding to the ORL1 receptor.
ORL1 Binding (binding) of nociceptin associated with orphanin
1) Confidence 0.33 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.88
Similar to opioid receptors, nociceptin binding to the ORL1 receptor was altered by Na+, GTPgammaS and dithiothreitol.
ORL1 Binding (binding) of nociceptin associated with orphanin and opioid receptor
2) Confidence 0.33 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.85
Morphine, naloxone, naltrindole, nor-Binaltorphimine and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) inhibited nociceptin binding to ORL1 receptor with Ki values of 36, 24, 0.4, 8 and 28 microM, respectively.
ORL1 Binding (binding) of nociceptin associated with orphanin, narcan and morphine
3) Confidence 0.33 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.87
Pretreatment with dithiothreitol inhibited nociceptin binding to the ORL1 receptor.
ORL1 Binding (binding) of nociceptin associated with orphanin
4) Confidence 0.33 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.95
In the present study, it was found that guinea pig brain contains receptors to which nociceptin binds much more strongly than to ORL1 receptors expressed in human 293 cells.
ORL1 Binding (binds) of nociceptin in brain associated with orphanin
5) Confidence 0.24 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8798582 Disease Relevance 0.23 Pain Relevance 0.83

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