INT64484

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Context Info
Confidence 0.33
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.51
Pain Relevance 10.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC) extracellular region (PNOC)
Anatomy Link Frequency
neocortex 1
brain 1
temporal lobe 1
PNOC (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 110 100.00 Very High Very High Very High
Neuropeptide 36 100.00 Very High Very High Very High
opioid receptor 40 99.96 Very High Very High Very High
Opioid 17 99.90 Very High Very High Very High
Pain 19 99.78 Very High Very High Very High
Acute pain 2 99.08 Very High Very High Very High
neuralgia 6 98.70 Very High Very High Very High
Analgesic 5 98.70 Very High Very High Very High
Inflammation 4 98.70 Very High Very High Very High
cOX1 2 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 16 99.78 Very High Very High Very High
Epilepsy 21 99.14 Very High Very High Very High
Sclerosis 9 98.88 Very High Very High Very High
Convulsion 3 96.72 Very High Very High Very High
Cancer 3 96.28 Very High Very High Very High
INFLAMMATION 4 95.28 Very High Very High Very High
Nervous System Injury 2 94.60 High High
Hyperalgesia 3 89.00 High High
Neuropathic Pain 2 87.00 High High
Intractable Pain 2 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.
nociceptin Binding (binding) of in neocortex associated with epilepsy, orphanin and opioid
1) Confidence 0.33 Published 2009 Journal Neurobiol. Dis. Section Title Doc Link 19573600 Disease Relevance 0.88 Pain Relevance 0.52
Nociceptin binding was insensitive to low nanomolar concentrations of opioid receptor-selective agonists and antagonists.
Nociceptin Binding (binding) of associated with antagonist, orphanin, agonist and opioid receptor
2) Confidence 0.29 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.96
Age of seizure onset correlated positively with [3H]DAMGO binding and DAMGO-stimulated [35S]GTPgammaS binding, whereas epilepsy duration correlated negatively with [3H]DAMGO and [3H]nociceptin binding, and positively with [3H]forskolin binding.
nociceptin Binding (binding) of associated with epilepsy, convulsion and orphanin
3) Confidence 0.28 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19573600 Disease Relevance 1.02 Pain Relevance 0.59
Patients with temporal lobe epilepsy associated with mesial sclerosis (MTLE) or secondary to tumor or vascular lesion showed enhanced [3H]DAMGO and [3H]forskolin binding, lower DAMGO-stimulated [35S]GTPgammaS binding and no significant changes in nociceptin-stimulated G-protein. [3H]Nociceptin binding was lower in patients with MTLE.
Nociceptin Binding (binding) of in temporal lobe associated with epilepsy, cancer, orphanin and sclerosis
4) Confidence 0.28 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19573600 Disease Relevance 1.05 Pain Relevance 0.59
Similar to opioid receptors, nociceptin binding to the ORL1 receptor was altered by Na+, GTPgammaS and dithiothreitol.
nociceptin Binding (binding) of associated with orphanin and opioid receptor
5) Confidence 0.22 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.85
Pretreatment with dithiothreitol inhibited nociceptin binding to the ORL1 receptor.
nociceptin Binding (binding) of associated with orphanin
6) Confidence 0.22 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.95
Na+ increased the Kd of nociceptin binding to the ORL1 receptor.
nociceptin Binding (binding) of associated with orphanin
7) Confidence 0.22 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.87
In the present study, it was found that guinea pig brain contains receptors to which nociceptin binds much more strongly than to ORL1 receptors expressed in human 293 cells.
nociceptin Binding (binds) of in brain associated with orphanin
8) Confidence 0.21 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8798582 Disease Relevance 0.23 Pain Relevance 0.76
GTPgammaS decreased the apparent Bmax of [125I][Tyr14]nociceptin binding but had no effect on the Kd of the remaining sites.
nociceptin Binding (binding) of associated with orphanin
9) Confidence 0.19 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.90
This review focuses on current knowledge concerning mechanisms and pathways for pain induced by prostaglandins and their interactions with novel neuropeptides nociceptin/orphanin FQ and nocistatin derived from the same opioid precursor protein.
nociceptin Binding (interactions) of associated with pain, orphanin, neuropeptide and opioid
10) Confidence 0.17 Published 2001 Journal Neurosci. Res. Section Abstract Doc Link 11755218 Disease Relevance 1.12 Pain Relevance 1.51
Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin.
nociceptin Binding (interactions) of associated with pain, analgesic, orphanin and neuropeptide
11) Confidence 0.17 Published 2001 Journal Neurosci. Res. Section Title Doc Link 11755218 Disease Relevance 1.21 Pain Relevance 2.37
To illustrate this point, Figure 2 shows a hierarchical alignment for prepronociceptin from five species (human, chimp, mouse, rat, cow), where the boxes depict the functional element sequence.
prepronociceptin Binding (alignment) of
12) Confidence 0.05 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2603333 Disease Relevance 0 Pain Relevance 0

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