INT64499

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 123
Total Number 125
Disease Relevance 52.73
Pain Relevance 27.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
monocytes 11
plasma 7
macrophages 7
neutrophils 4
amnion 2
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 526 100.00 Very High Very High Very High
Inflammatory stimuli 254 100.00 Very High Very High Very High
Inflammatory mediators 116 100.00 Very High Very High Very High
rheumatoid arthritis 411 99.88 Very High Very High Very High
Bile 47 99.76 Very High Very High Very High
Inflammation 2490 99.70 Very High Very High Very High
cytokine 1685 99.60 Very High Very High Very High
Electroencephalography 124 99.52 Very High Very High Very High
imagery 16 99.42 Very High Very High Very High
Morphine 1053 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3327 100.00 Very High Very High Very High
Rheumatoid Arthritis 520 99.88 Very High Very High Very High
Cirrhosis 534 99.86 Very High Very High Very High
Chronic Fatigue Syndrome 150 99.84 Very High Very High Very High
Diabetes Mellitus 97 99.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 369 99.68 Very High Very High Very High
Infection 508 99.52 Very High Very High Very High
Cognitive Disorder 59 99.52 Very High Very High Very High
Chronic Hepatitis 20 99.48 Very High Very High Very High
Asthma 216 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Results showed more alveolar bone loss in patients with cardiac disease than in patients without cardiac disease, but there was no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis.
Positive_regulation (levels) of LPS
1) Confidence 0.49 Published 2008 Journal J. Periodontol. Section Body Doc Link 19053924 Disease Relevance 0.05 Pain Relevance 0
Anti-LPS IgG titers were increased in 45% of patients at enrollment and in 48% of patients at discharge (p <0.0001).
Positive_regulation (increased) of LPS
2) Confidence 0.49 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11356388 Disease Relevance 0.62 Pain Relevance 0.40
Anti-LPS IgA titers were increased in 27% of patients at enrollment and in 33% of patients at discharge (p <0.0001).
Positive_regulation (increased) of LPS
3) Confidence 0.49 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11356388 Disease Relevance 0.62 Pain Relevance 0.40
The stimulation frequency was increased from 4 pulses per second (pps) at increments of 2 pps until a cramp was induced.
Positive_regulation (increased) of pps associated with cramps
4) Confidence 0.49 Published 2009 Journal Muscle Nerve Section Abstract Doc Link 19623637 Disease Relevance 0.43 Pain Relevance 0
RESULTS: One month after vaccination, both groups had significant increases in the geometric mean concentration of capsule PPS-specific antibody and in the mean fold increase in antibody levels to all 7 serotypes, compared with prevaccination levels.
Positive_regulation (increases) of PPS in capsule
5) Confidence 0.49 Published 2004 Journal Semin. Arthritis Rheum. Section Body Doc Link 14978666 Disease Relevance 0.29 Pain Relevance 0
However, this peptidomimetic compound did not show any effect on LPS induced MAPK activation.
Positive_regulation (activation) of LPS
6) Confidence 0.45 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 12784915 Disease Relevance 0 Pain Relevance 0.14
LPS or IFN-gamma activation of uninfected monocytes produced substantially higher levels of Quin than found in similarly stimulated HIV-1-infected monocytes.
Positive_regulation (activation) of LPS in monocytes associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.38 Published 1996 Journal J. Neurovirol. Section Abstract Doc Link 8799202 Disease Relevance 1.52 Pain Relevance 0.07
However, in CORT-12-LPS and CORT-144-LPS the plasma concentrations of the aforementioned inflammatory mediators were significantly increased compared to CORT-LPS and CORT-6-LPS groups.
Positive_regulation (increased) of LPS in plasma associated with inflammatory mediators and inflammatory stimuli
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.37 Pain Relevance 1.15
However, in CORT-12-LPS and CORT-144-LPS the plasma concentrations of the aforementioned inflammatory mediators were significantly increased compared to CORT-LPS and CORT-6-LPS groups.
Positive_regulation (increased) of CORT-12-LPS in plasma associated with inflammatory mediators and inflammatory stimuli
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.37 Pain Relevance 1.16
Morphine pre-treatment potentiates the effects of LPS on endothelial cell viability, and on LPS induction of IL-1beta secretion from 1alpha, 25-dihydroxy-vitamin D3-treated HL-60 human leukemia cells.
Positive_regulation (induction) of LPS in endothelial cell associated with leukemia and morphine
10) Confidence 0.33 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727765 Disease Relevance 0.31 Pain Relevance 0.78
The absence of FBS in the culture medium strongly limits the LPS activation of TNFalpha secretion (Figure 5A).
Positive_regulation (activation) of LPS
11) Confidence 0.30 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.17 Pain Relevance 0.03
Second, in (1) the variable DR* is assumed to be the convoluted signal that propagates the LPS signaling initiating the transcriptional synthesis of both the pro-inflammatory response (P) and the mRNA of TLR4 (mRNA,R).
Positive_regulation (propagates) of LPS associated with inflammatory response and inflammatory stimuli
12) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.78 Pain Relevance 0.44
One of the key aspects is the integration of the opposing effect of two crucial signaling pathways: one associated with the transcriptional dynamics that are elicited in response to endotoxin stimulus (LPS) and one related to the genomic signaling of exogenous corticosteroids.
Positive_regulation (response) of LPS associated with corticosteroid and inflammatory stimuli
13) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.61 Pain Relevance 0.42
However, in CORT-12-LPS and CORT-144-LPS the plasma concentrations of the aforementioned inflammatory mediators were significantly increased compared to CORT-LPS and CORT-6-LPS groups.
Positive_regulation (increased) of LPS in plasma associated with inflammatory mediators and inflammatory stimuli
14) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.32 Pain Relevance 1.10
However, in CORT-12-LPS and CORT-144-LPS the plasma concentrations of the aforementioned inflammatory mediators were significantly increased compared to CORT-LPS and CORT-6-LPS groups.
Positive_regulation (increased) of CORT-6-LPS in plasma associated with inflammatory mediators and inflammatory stimuli
15) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.32 Pain Relevance 1.11
CD14-deficient cell lines such as Chinese hamster ovary are unresponsive to LPS at high doses, and cell lines that show poor LPS activation can be converted to show high activation when transfected with the CD14 gene [71].
Positive_regulation (activation) of LPS in ovary
16) Confidence 0.27 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.27 Pain Relevance 0.14
Monocytes without LPS stimulation exclusively expressed COX-1 on Western blotting analysis, whereas LPS stimulation induced COX-2 expression.
Positive_regulation (stimulation) of LPS in Monocytes
17) Confidence 0.24 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11804398 Disease Relevance 0.16 Pain Relevance 0.49
The nitric oxide donor SNAP also blocked iNOS induction while preincubation of atrial fragments with an inhibitor of NOS, L-NAME, prior to morphine or anandamide exposure, restored LPS + IFN-gamma induction of iNOS.
Positive_regulation (induction) of LPS
18) Confidence 0.24 Published 2000 Journal Acta Pharmacol. Sin. Section Body Doc Link 11324436 Disease Relevance 0 Pain Relevance 0
M) strongly increases the activation of LPS induced TNFalpha secretion (more than 2-fold).
Positive_regulation (activation) of LPS
19) Confidence 0.23 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.05 Pain Relevance 0.04
In a similar way, wortmannin increases LPS induced TNFalpha gene transcription by a factor of 2 (Figure 4B).
Positive_regulation (induced) of LPS
20) Confidence 0.22 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.06 Pain Relevance 0.05

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