INT64525

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Context Info
Confidence 0.10
First Reported 1996
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.31
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ndp) extracellular region (Ndp) cellular_component (Ndp)
biological_process (Ndp)
Anatomy Link Frequency
ventromedial hypothalamic nucleus 2
Ndp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 9 99.58 Very High Very High Very High
melanocortin 1 receptor 3 96.62 Very High Very High Very High
antagonist 6 90.92 High High
Nucleus accumbens 1 74.56 Quite High
Ventral tegmentum 1 71.92 Quite High
opiate 1 57.20 Quite High
Disease Link Frequency Relevance Heat
Obesity 3 89.24 High High
Sprains And Strains 1 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that OLETF rats show a reduction in total [125I]NDP-MSH MC receptor binding in the ventromedial hypothalamic nucleus, perhaps reflecting an increased release of MC peptides in this region.
Negative_regulation (reduction) of NDP-MSH MC receptor Binding (binding) of in ventromedial hypothalamic nucleus
1) Confidence 0.10 Published 2000 Journal Brain Res. Section Abstract Doc Link 10661510 Disease Relevance 0.31 Pain Relevance 0.13
Substitution of aspartic acid117 and histidine260 by alanine in melanocortin 1 receptor resulted in a 4.75-fold decrease (Ki 4541 +/- 644 nM) and an 11-fold increase (Ki 84.29 +/- 4.53 nM), respectively, in the relative potency of 153N-6 for competitively inhibiting [125I]NDP-MSH binding.
Negative_regulation (inhibiting) of NDP-MSH Binding (binding) of associated with melanocortin 1 receptor and potency
2) Confidence 0.01 Published 1996 Journal Peptides Section Abstract Doc Link 8801544 Disease Relevance 0 Pain Relevance 0.30
The relative potency order of 153N-6 for inhibiting [125I]NDP-MSH binding was MC1R (Ki 955 +/- 35.7 nM) = MC4R (Ki 1151 +/- 106 nM) > MC3R (Ki 3229 +/- 637 nM) > MC5R (Ki 6286 +/- 462 nM), which is different than the potency order of either NDP-MSH or alpha-MSH.
Negative_regulation (inhibiting) of NDP-MSH Binding (binding) of associated with potency
3) Confidence 0.01 Published 1996 Journal Peptides Section Abstract Doc Link 8801544 Disease Relevance 0 Pain Relevance 0.29
Substitution of aspartic acid117 and histidine260 by alanine in melanocortin 1 receptor resulted in a 4.75-fold decrease (Ki 4541 +/- 644 nM) and an 11-fold increase (Ki 84.29 +/- 4.53 nM), respectively, in the relative potency of 153N-6 for competitively inhibiting [125I]NDP-MSH binding.
Negative_regulation (inhibiting) of NDP-MSH Binding (binding) of associated with melanocortin 1 receptor and potency
4) Confidence 0.01 Published 1996 Journal Peptides Section Abstract Doc Link 8801544 Disease Relevance 0 Pain Relevance 0.30

General Comments

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