INT6453

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Context Info
Confidence 0.19
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.81
Pain Relevance 7.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
neural 4
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 43 100.00 Very High Very High Very High
Dopamine 39 100.00 Very High Very High Very High
Morphine 14 100.00 Very High Very High Very High
Opioid 14 100.00 Very High Very High Very High
narcan 7 100.00 Very High Very High Very High
Intracerebroventricular 1 98.52 Very High Very High Very High
mu opioid receptor 1 98.00 Very High Very High Very High
opiate 10 97.24 Very High Very High Very High
cerebral cortex 37 97.04 Very High Very High Very High
Buprenorphine 1 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 100.00 Very High Very High Very High
Cognitive Disorder 11 76.64 Quite High
INFLAMMATION 1 63.36 Quite High
Stress 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Cerebellar Diseases 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double reciprocal analysis suggested a mixed competitive-noncompetitive type of inhibition of [D-Ala2,D-Leu5]-enkephalin binding by dihydromorphine.
Negative_regulation (inhibition) of D-Ala2 Binding (binding) of associated with enkephalin
1) Confidence 0.19 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6287305 Disease Relevance 0 Pain Relevance 1.23
Kinetic analysis revealed that Ca2+ decreased the rate of dissociation of [D-Ala2,D-Leu5]-enkephalin without affecting the rate of association, thereby increasing the affinity.
Negative_regulation (decreased) of D-Ala2 Binding (dissociation) of associated with enkephalin
2) Confidence 0.19 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6287305 Disease Relevance 0 Pain Relevance 1.32
We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.
Negative_regulation (reduces) of D2 Binding (alteration) of associated with dopamine and diabetes mellitus
3) Confidence 0.10 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.81 Pain Relevance 0.45
EC-NaCl50, the concentration of apomorphine which inhibited 50% binding of the radioactive naloxone and D-ala2, D-leu5-enkephalin in the absence of NaCl were 20 and 42 microM, respectively.
Negative_regulation (inhibited) of D-ala2 Binding (binding) of associated with narcan and enkephalin
4) Confidence 0.07 Published 1980 Journal Biull Eksp Biol Med Section Abstract Doc Link 6256025 Disease Relevance 0 Pain Relevance 0.79
Yet raising the infusion rate to 1.1 mg/kg/h reduced morphine's efficacy. (3)H-DAMGO D-Ala2, N-MePhe4, Gly5-ol-enkephalin) binding revealed no change in the affinity or density of mu-opioid receptors at any age or in any treatment group.
Negative_regulation (reduced) of D-Ala2 Binding (binding) of associated with mu opioid receptor, enkephalin and morphine
5) Confidence 0.05 Published 2002 Journal Pharmacology Section Abstract Doc Link 12169760 Disease Relevance 0 Pain Relevance 1.08
Intracerebroventricular administration of antisense DNA to the cloned delta receptor selectively decreased [3H][D-Ala2,D-Leu5]enkephalin binding to the delta ncx-1 site.
Negative_regulation (decreased) of D-Ala2 Binding (binding) of associated with enkephalin and intracerebroventricular
6) Confidence 0.04 Published 1998 Journal Peptides Section Abstract Doc Link 9700759 Disease Relevance 0 Pain Relevance 0.64
Concomitantly, the fatty acids, but not the methyl esters, inhibited the specific binding of the tritiated mu-, delta-, and kappa-opioids Tyr-D-Ala-Gly-(Me)Phe-Gly-ol (DAMGO), [D-Pen2,D-Pen5]enkephalin (DPDPE), and U69,593, respectively.
Negative_regulation (inhibited) of D-Pen2 Binding (binding) of associated with enkephalin and opioid
7) Confidence 0.02 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1328516 Disease Relevance 0 Pain Relevance 0.34
In a titratable manner, the Fab fragments noncompetitively inhibited the binding of the mu selective peptide [D-Ala2,(Me)Phe4,Gly(OH)5][3H] enkephalin and the delta selective peptide [D-Pen2,D-Pen5] [3H]enkephalin (where Pen represents penicillamine) to neural membranes.
Negative_regulation (inhibited) of D-Pen2 Binding (binding) of in neural associated with enkephalin
8) Confidence 0.02 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 3023329 Disease Relevance 0 Pain Relevance 0.73
In a titrable manner, the Fab fragments noncompetitively inhibited the binding of the mu selective peptide, [3H][D-Ala2, MePhe4, 2Gly-ol5] enkephalin (DAGO) and the delta selective peptide, [3H][D-Pen2, D-Pen5] enkephalin (DPDPE), to neural membranes.
Negative_regulation (inhibited) of D-Pen2 Binding (binding) of in neural associated with enkephalin
9) Confidence 0.00 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828974 Disease Relevance 0 Pain Relevance 0.71

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