INT64538

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 11.65
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
limb 1
CTP 1
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 74 99.02 Very High Very High Very High
nud 1 70.04 Quite High
cva 19 69.88 Quite High
depression 4 63.52 Quite High
anesthesia 35 56.08 Quite High
ischemia 35 46.80 Quite Low
imagery 2 38.24 Quite Low
Inflammation 25 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophic Cardiomyopathy 8 100.00 Very High Very High Very High
Heart Murmurs 1 99.76 Very High Very High Very High
Sepsis 16 99.72 Very High Very High Very High
Myocardial Infarction 88 99.42 Very High Very High Very High
Congenital Anomalies 7 99.24 Very High Very High Very High
Cv General 3 Under Development 34 99.02 Very High Very High Very High
Cv General 4 Under Development 1 98.36 Very High Very High Very High
Coronary Heart Disease 49 98.32 Very High Very High Very High
Stroke 5 97.28 Very High Very High Very High
Injury 71 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The BA recognizes the C-terminal portion (CTP) of cTnI, whereas the other assays recognize the N-terminal portion (NTP) [31].
cTnI Binding (recognizes) of in CTP
1) Confidence 0.48 Published 2004 Journal BMC Emerg Med Section Body Doc Link PMC487900 Disease Relevance 0 Pain Relevance 0
Cardiac troponin I (cTnI) is now widely recognized as one of the preeminent biochemical markers for the diagnosis of myocardial injury.
cTnI Binding (recognized) of associated with injury
2) Confidence 0.45 Published 2000 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 11045766 Disease Relevance 0.48 Pain Relevance 0.08
An elevated cTnI is clearly associated with an unfavorable outcome.


cTnI Binding (associated) of
3) Confidence 0.44 Published 2006 Journal Eur. J. Intern. Med. Section Body Doc Link 16490684 Disease Relevance 0.11 Pain Relevance 0
The present study measured cardiac troponin T(TnT) for the pathophysiological analysis of evolving ischemic myocardial injury in 35 patients with unstable angina (3: Class IB, 32: Class IIIB) and in 40 patients undergoing coronary reperfusion therapy for acute myocardial infarction.
cardiac troponin Binding (measured) of associated with angina, injury and myocardial infarction
4) Confidence 0.36 Published 1996 Journal Jpn. Circ. J. Section Abstract Doc Link 8803720 Disease Relevance 0.43 Pain Relevance 0.16
This association between cTnI and mortality was more pronounced among elderly patients (>65 years of age).
cTnI Binding (association) of
5) Confidence 0.36 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1269455 Disease Relevance 0.45 Pain Relevance 0
The cTnI levels were also not associated with increasing age.
cTnI Binding (associated) of
6) Confidence 0.34 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.32 Pain Relevance 0
Both reviewers remained blinded to all cTnI assay results.
cTnI Binding (blinded) of
7) Confidence 0.32 Published 2004 Journal BMC Emerg Med Section Body Doc Link PMC487900 Disease Relevance 0.83 Pain Relevance 0.14
Many studies performed on human denoting that glycine absorption causes echocardiogram changes and it is associated with increased troponin I [6].
troponin I Binding (associated) of
8) Confidence 0.27 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2891743 Disease Relevance 0.86 Pain Relevance 0
Discordances were found between cTnI and cTnT in sample I but not in sample II; positive cTnT/negative cTnI was more common than the opposite discordance (P = 0.027). cTnT was more frequently increased in patients with unstable angina pectoris (UAP) than cTnI (P = 0.038), with no significant differences between sample I and sample II; discordant results with respect to cTnI and cTnT appeared in 6 (33%) of these patients, all of which were positive for cTnT and negative for cTnI.
cTnI Binding (found) of associated with angina
9) Confidence 0.25 Published 1998 Journal Clin. Chem. Section Abstract Doc Link 9665420 Disease Relevance 0.74 Pain Relevance 0.34
Four patients with UAP (22%) developed AMI within 4 months; three were associated with increased cTnI and cTnT at the time of initial testing, and one was discordant (positive cTnT).
cTnI Binding (associated) of associated with angina and myocardial infarction
10) Confidence 0.25 Published 1998 Journal Clin. Chem. Section Abstract Doc Link 9665420 Disease Relevance 1.12 Pain Relevance 0.42
Many acceptable studies were performed about the sensitivity and specify of cTnl (Adams et al 1990, 1993) Diagnosis and postoperative management is presently based on assessment of cTnI (Coriat 2001).
cTnI Binding (assessment) of
11) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291320 Disease Relevance 0.85 Pain Relevance 0.09
CK-MB, cTnI and cTnT were equally efficient for the diagnosis of acute myocardial infarction, irrespective of the final diagnostic criteria used.
cTnI Binding (efficient) of associated with myocardial infarction
12) Confidence 0.19 Published 2001 Journal Ann. Clin. Biochem. Section Abstract Doc Link 11587129 Disease Relevance 0.26 Pain Relevance 0.08
Troponin C binds to calcium ions in order to produce movement; Troponin T binds to tropomyosin, interlocking it to form a troponin-tropomyosin complex; Troponin I binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place.
Troponin I Binding (binds) of
13) Confidence 0.14 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.48 Pain Relevance 0
After eccentric isokinetic exercise, healthy volunteers showed a rise in creatine kinase MB mass (AxSYM) but not in cTnI.
cTnI Neg (not) Binding (rise) of
14) Confidence 0.12 Published 1999 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 10587695 Disease Relevance 0.43 Pain Relevance 0.09
In this case, the HAs bind to the capture antibody and the conjugate antibody, simulating cTnI.
cTnI Binding (bind) of
15) Confidence 0.07 Published 2008 Journal Am J Emerg Med Section Abstract Doc Link 18926374 Disease Relevance 0.36 Pain Relevance 0.11
g/L.[4] Troponin I has been cited as the most sensitive cardiac enzyme marker in patients with clinically suspected myocarditis and has been found to correlate with immunohistologic assessments.[10,11]
Troponin I Binding (cited) of associated with coronary heart disease
16) Confidence 0.02 Published 2003 Journal BMC Infect Dis Section Body Doc Link PMC183865 Disease Relevance 1.10 Pain Relevance 0.23
Apical hypertrophic cardiomyopathy (AHC) is associated with neurological abnormalities such as transient ischemic attack, stroke, limb-girdle muscular dystrophy, or eosinophilic myositis in single cases.
Apical hypertrophic cardiomyopathy Binding (associated) of in limb associated with rhinitis, hypertrophic cardiomyopathy, stroke, cv general 4 under development, congenital anomalies, frailty and myositis
17) Confidence 0.01 Published 2007 Journal J Cardiovasc Med (Hagerstown) Section Abstract Doc Link 18163025 Disease Relevance 1.84 Pain Relevance 0.09

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