INT64539

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 9.42
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gpx3) oxidoreductase activity (Gpx3) extracellular region (Gpx3)
Anatomy Link Frequency
extracellular matrix 6
Plasma 2
lung 2
Liver 1
choroid plexus 1
Gpx3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 65 100.00 Very High Very High Very High
fibrosis 67 99.38 Very High Very High Very High
Inflammation 182 98.76 Very High Very High Very High
metalloproteinase 41 96.52 Very High Very High Very High
Central nervous system 26 95.84 Very High Very High Very High
gABA 7 94.16 High High
Mechanotransduction 3 93.56 High High
ischemia 16 93.28 High High
Inflammatory mediators 7 89.68 High High
Glutamate 49 88.64 High High
Disease Link Frequency Relevance Heat
Cirrhosis 15 99.38 Very High Very High Very High
Brain Injury 20 98.84 Very High Very High Very High
INFLAMMATION 217 98.76 Very High Very High Very High
Hyperplasia 13 98.08 Very High Very High Very High
Hypertrophy 7 98.06 Very High Very High Very High
Lung Injury 58 97.96 Very High Very High Very High
Cicatrix 14 97.48 Very High Very High Very High
Muscular Spasm 2 97.20 Very High Very High Very High
Disease 57 96.96 Very High Very High Very High
Coronary Stenosis 4 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GPX3 expression is induced by activation of PPARgamma and is responsible for its extracellular antioxidant effects [59].
Gene_expression (expression) of GPX3
1) Confidence 0.58 Published 2010 Journal Biol Trace Elem Res Section Body Doc Link PMC2855032 Disease Relevance 0.18 Pain Relevance 0
The observed increased expression of some genes, including nitric oxide synthase 2A [18-21], CD14 antigen [22], T cell receptor alpha locus [23], small inducible cytokine A5 (RANTES) [24], mucin [25,26], tryptases [27,28], cathepsin C [29], and possibly glutathione peroxidase 3 [30], spleen tyrosine kinase [31], and also cathepsin G [32], a serine protease, matches previously published results and confirms the implication of candidate genes already associated with asthma in previous studies.
Spec (observed) Gene_expression (expression) of peroxidase 3 in spleen associated with asthma and cytokine
2) Confidence 0.43 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.94 Pain Relevance 0.17
GPx2 (gastrointestinal GPx) and GPx5 (sperm nuclei GPx) have tissue specific localization, while the expression of GPx3 (extracellular GPx) was found to be extremely low in mouse brain 41.
Gene_expression (expression) of GPx3 in brain
3) Confidence 0.24 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.13 Pain Relevance 0
Extracellular matrix proteins
Gene_expression (proteins) of Extracellular in Extracellular matrix
4) Confidence 0.10 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.25 Pain Relevance 0
On the other hand, the absence of IL-1R1 signaling results in attenuated hypertrophy of astrocytes, delayed induction of cellular GFAP, decreased induction of PAR-1 and unperturbed production of extracellular matrix proteins.
Gene_expression (production) of extracellular in extracellular matrix associated with hypertrophy
5) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.51 Pain Relevance 0.24
Last, we analyzed the expression of several extracellular matrix proteins that are known constituents of the astroglial scar to assess whether scar formation will be reduced in the absence of IL-1R1 signaling.


Spec (analyzed) Gene_expression (expression) of extracellular in extracellular matrix associated with cicatrix
6) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.81 Pain Relevance 0.11
Endothelial cells of the choroid plexus and other CVO express proteoglycans, fibronectin and other extracellular matrix proteins [33,34], which may bind Gf.
Gene_expression (express) of extracellular in choroid plexus
7) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.58 Pain Relevance 0.29
Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily by matrix metalloproteinases (MMPs).
Gene_expression (synthesis) of extracellular in Liver associated with fibrosis, cirrhosis and metalloproteinase
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2892485 Disease Relevance 1.00 Pain Relevance 0.37
The observed differential activation of genes involved in the coagulation cascade, extracellular matrix production and intercellular communication in the context of VILI, suggests that this disease represents a complex rather than purely inflammatory process, where cellular mechanotransduction plays a key role [5], [12], [13].
Gene_expression (production) of extracellular in extracellular matrix associated with lung injury, inflammation, mechanotransduction and disease
9) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 1.25 Pain Relevance 0.20
Their proliferation corresponds to an increase in expression of extracellular matrix structural genes and proteases that are essential for tissue remodeling.
Gene_expression (expression) of extracellular in extracellular matrix
10) Confidence 0.02 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.06 Pain Relevance 0.06
At 3 days the top networks identified by IPA involve cell cycle progression (up-regulation of Foxm1, Cdc2, Cdc20, Ccnd1 and IL6 - Figure 4A), and activation of fibroblastic cells with production of extracellular matrix components (up-regulation of Igf1, Tnfrsf12A, Eln, Fbn1, Col3A1, Serpine1 and Thbs1 - Figure 4B).
Gene_expression (production) of extracellular in extracellular matrix
11) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.47 Pain Relevance 0.23
Analysis of transcriptomic patterns during post-pneumonectomy lung regeneration suggests an integral role for mesenchymal cells, in particular in the production of extracellular matrix as mentioned above.
Gene_expression (production) of extracellular in lung
12) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.25 Pain Relevance 0.14
The transcriptomic patterns suggest that mesenchymal cells are activated during lung regeneration, resulting in increased expression of common extracellular matrix components, in concert with transcriptional control of inflammatory and immunomodulatory pathways.
Gene_expression (expression) of extracellular in lung associated with inflammation
13) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.34 Pain Relevance 0.16
The expression of extracellular perineuronal nets (PNNs) in visual cortex matches the development of the critical period, is delayed by dark rearing and is restricted mostly to GABA-expressing neurons (Guimaraes et al. 1990; Hartig et al. 1992).
Gene_expression (expression) of extracellular in neurons associated with gaba
14) Confidence 0.01 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0 Pain Relevance 0.08
Plasma FPA and PF 4 levels in group 1 were also significantly higher than those in normal subjects and group 2.
Gene_expression (levels) of Plasma FPA in Plasma
15) Confidence 0.00 Published 1996 Journal Jpn. Circ. J. Section Abstract Doc Link 8803721 Disease Relevance 1.32 Pain Relevance 0.77
Plasma FPA and PF 4 levels in group 1 were also significantly higher than those in normal subjects and group 2.
Gene_expression (higher) of Plasma FPA in Plasma
16) Confidence 0.00 Published 1996 Journal Jpn. Circ. J. Section Abstract Doc Link 8803721 Disease Relevance 1.33 Pain Relevance 0.81

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox