INT64558

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 88
Total Number 89
Disease Relevance 26.76
Pain Relevance 36.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
neuronal 12
dorsal horn 7
spinal cord 4
neurons 4
brain 3
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 326 100.00 Very High Very High Very High
Dorsal horn 298 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 61 100.00 Very High Very High Very High
Clonidine 33 99.98 Very High Very High Very High
ischemia 31 99.78 Very High Very High Very High
nMDA receptor 201 99.72 Very High Very High Very High
Brush evoked pain 5 99.72 Very High Very High Very High
Morphine 36 99.70 Very High Very High Very High
Arthritis 28 99.70 Very High Very High Very High
medulla 26 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 77 100.00 Very High Very High Very High
Injury 99 99.92 Very High Very High Very High
Drug Induced Neurotoxicity 13 99.92 Very High Very High Very High
Cv General 4 Under Development 5 99.78 Very High Very High Very High
Diabetes Mellitus 19 99.74 Very High Very High Very High
Neuropathic Pain 44 99.72 Very High Very High Very High
Arthritis 99 99.70 Very High Very High Very High
Toxicity 7 99.58 Very High Very High Very High
Hyperalgesia 67 99.48 Very High Very High Very High
Increased Venous Pressure Under Development 8 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cerebrovascular coupling under neuronal nitric oxide synthase (nNOS) inhibition was investigated in alpha-chloralose anesthetized rats.
Negative_regulation (inhibition) of nNOS in neuronal associated with neuronal nitric oxide synthase
1) Confidence 0.58 Published 2007 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 16883353 Disease Relevance 0 Pain Relevance 0.09
Functional uncoupling of hemodynamic from neuronal response by inhibition of neuronal nitric oxide synthase.
Negative_regulation (inhibition) of neuronal nitric oxide synthase in neuronal associated with anesthesia and neuronal nitric oxide synthase
2) Confidence 0.58 Published 2007 Journal J. Cereb. Blood Flow Metab. Section Title Doc Link 16883353 Disease Relevance 0 Pain Relevance 0.20
The cerebrovascular coupling under neuronal nitric oxide synthase (nNOS) inhibition was investigated in alpha-chloralose anesthetized rats.
Negative_regulation (inhibition) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
3) Confidence 0.58 Published 2007 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 16883353 Disease Relevance 0 Pain Relevance 0.09
Because NO and IL-1beta modulate SNS activity, the stimulatory action of phenol on the SNS could be mediated by downregulation of nNOS and IL-1beta in the brain.
Negative_regulation (downregulation) of nNOS in SNS
4) Confidence 0.58 Published 2002 Journal Am. J. Hypertens. Section Abstract Doc Link 12160195 Disease Relevance 0.67 Pain Relevance 0.29
Downregulation of nNOS and IL-1beta, two modulators of sympathetic nervous system (SNS) activity may mediate this activation.
Negative_regulation (Downregulation) of nNOS in sympathetic nervous system
5) Confidence 0.58 Published 2002 Journal Am. J. Hypertens. Section Abstract Doc Link 12160195 Disease Relevance 0.50 Pain Relevance 0.22
Intrarenal injection of phenol in rats causes a persistent elevation in blood pressure (BP) and in norepinephrine (NE) secretion from the posterior hypothalamus (PH), and downregulation of neuronal nitric oxide synthase (nNOS) and interleukin-1beta (IL-1beta) in the PH.
Negative_regulation (downregulation) of nNOS in posterior associated with pressure and volume under development and neuronal nitric oxide synthase
6) Confidence 0.58 Published 2002 Journal Am. J. Hypertens. Section Abstract Doc Link 12160195 Disease Relevance 0.45 Pain Relevance 0.17
In contrast, IT injection of a selective inhibitor of NOS-1, nNOS inhibitor-I, had no effect in either model.
Negative_regulation (inhibitor) of NOS-1 associated with intrathecal
7) Confidence 0.56 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17561811 Disease Relevance 0.64 Pain Relevance 0.55
In contrast, IT injection of a selective inhibitor of NOS-1, nNOS inhibitor-I, had no effect in either model.
Negative_regulation (inhibitor) of nNOS associated with intrathecal
8) Confidence 0.56 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17561811 Disease Relevance 0.64 Pain Relevance 0.56
In thoracic DRG, nNOS mRNA was reduced 48 h after SP(1-7).
Negative_regulation (reduced) of nNOS mRNA in thoracic associated with substance p
9) Confidence 0.55 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11556883 Disease Relevance 0.28 Pain Relevance 1.12
Discernible down-regulation of nNOS mRNA was not detected until the last phase of endotoxemia.
Negative_regulation (down-regulation) of nNOS associated with endotoxemia
10) Confidence 0.53 Published 2001 Journal Shock Section Abstract Doc Link 11198360 Disease Relevance 0.72 Pain Relevance 0.27
Treatment of peanut oil alone did not affect iron-induced hippocampal cell loss with respect to iron group values. (4) Findings of our study suggest that 7-nitroindazole may have neuroprotective effects against iron-induced hippocampal neurotoxicity by inhibiting nNOS.
Negative_regulation (inhibiting) of nNOS associated with drug induced neurotoxicity
11) Confidence 0.51 Published 2007 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 17965933 Disease Relevance 0.17 Pain Relevance 0.15
Pretreatment with the selective nNOS inhibitor 7-nitroindazole (7-NI), dose- and time-dependently delayed the onset of clonus with a corresponding decrease in nNOS activity.
Negative_regulation (decrease) of nNOS
12) Confidence 0.51 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850575 Disease Relevance 0.23 Pain Relevance 0.50
SMTC was coinfused in amounts (20 microg.min(-1).kg(-1)) reported to selectively inhibit nNOS.
Negative_regulation (inhibit) of nNOS
13) Confidence 0.51 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18234741 Disease Relevance 0.29 Pain Relevance 0.13
Systemic treatment with a specific pharmacological inhibitor of nNOS failed to prevent or reverse allodynia in nerve-injured rats.
Negative_regulation (inhibitor) of nNOS in nerve associated with allodynia
14) Confidence 0.51 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.90 Pain Relevance 0.96
Effects of inhibition of neuronal nitric oxide synthase on NMDA-induced changes in cerebral blood flow and oxygen consumption.
Negative_regulation (inhibition) of neuronal nitric oxide synthase in blood associated with neuronal nitric oxide synthase
15) Confidence 0.51 Published 2003 Journal Exp Brain Res Section Title Doc Link 12520415 Disease Relevance 0 Pain Relevance 0.27
Intra-ischemic CBF was reduced by nNOS inhibition, with ARL 17477, in normal and low-dose E2-treated OVX rats (4-8% baseline).
Negative_regulation (inhibition) of nNOS
16) Confidence 0.51 Published 1998 Journal Neuroreport Section Abstract Doc Link 9831465 Disease Relevance 0.43 Pain Relevance 0.31
Furthermore, the relatively modest effect of TRIM on nitrergic responses indicates that it is not a particularly reliable inhibitor of nNOS.
Negative_regulation (inhibitor) of nNOS
17) Confidence 0.50 Published 2007 Journal Nitric Oxide Section Abstract Doc Link 16769230 Disease Relevance 0 Pain Relevance 0.25
Thus, ONO-1714 is considered a potent inhibitor of nNOS in addition to iNOS.
Negative_regulation (inhibitor) of nNOS
18) Confidence 0.50 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15245789 Disease Relevance 0.27 Pain Relevance 0.56
METHODS: In anesthetized rats, N-nitro-L-arginine methylester (L-NAME) was used for nonselective inhibition of nitric oxide synthesis and 7-nitroindazole (7-NI) for inactivation of neuronal isoform of nitric oxide synthase (nNOS).
Negative_regulation (inactivation) of nNOS in neuronal
19) Confidence 0.43 Published 2004 Journal Kidney Int. Section Body Doc Link 15253725 Disease Relevance 0 Pain Relevance 0
The relatively selective inhibitor of neuronal NO synthase 7-nitroindazole (100 mg/kg ip) reduced the flow response evoked by microinjection of glutamate (-46 +/- 7%; n = 5; P < 0.05) but not acetylcholine (10 microM; P > 0.05; n = 6).
Negative_regulation (inhibitor) of neuronal NO synthase in neuronal associated with glutamate
20) Confidence 0.43 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8997354 Disease Relevance 0.08 Pain Relevance 0.67

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