INT64559

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.58
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
paw 2
brain 2
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 4 100.00 Very High Very High Very High
Dorsal horn 2 100.00 Very High Very High Very High
Morphine 9 98.76 Very High Very High Very High
Pain 3 90.76 High High
Antinociceptive 1 89.48 High High
withdrawal 2 85.36 High High
Spinal cord 1 75.00 Quite High
Calcium channel 1 74.48 Quite High
cINOD 3 74.00 Quite High
Hyperalgesia 1 67.68 Quite High
Disease Link Frequency Relevance Heat
Arthritis 9 99.84 Very High Very High Very High
Stress 6 94.80 High High
Diarrhoea 2 92.32 High High
Pain 1 90.76 High High
Blepharoptosis 1 88.68 High High
Morphine Dependence 1 70.76 Quite High
INFLAMMATION 2 51.36 Quite High
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the hypothesis that hind paw injection of formalin increases the number of dorsal horn neuronal nitric oxide synthase (nNOS) containing neurons.
Spec (investigated) Positive_regulation (increases) of Negative_regulation (number) of neuronal nitric oxide synthase in paw associated with dorsal horn and neuronal nitric oxide synthase
1) Confidence 0.41 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8805130 Disease Relevance 0.09 Pain Relevance 0.54
The mucosal expression levels of eNOS and iNOS but not nNOS mRNAs were enhanced in arthritic rats compared with normal rats.
Positive_regulation (enhanced) of Negative_regulation (levels) of nNOS associated with arthritis
2) Confidence 0.38 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19881222 Disease Relevance 1.15 Pain Relevance 0.20
Nifedipine treatment decreased the brain nNOS activity, induced by multiple administration of morphine.
Positive_regulation (induced) of Negative_regulation (decreased) of nNOS in brain associated with morphine
3) Confidence 0.26 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15605124 Disease Relevance 0.34 Pain Relevance 0.94

General Comments

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