INT64567

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.63
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
spinal cord 4
Purkinje cells 2
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 32 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
Spinal cord 30 99.28 Very High Very High Very High
Pain 20 99.24 Very High Very High Very High
tetrodotoxin 1 98.44 Very High Very High Very High
dexamethasone 43 98.32 Very High Very High Very High
substance P 34 98.20 Very High Very High Very High
spinal dorsal horn 11 96.52 Very High Very High Very High
GABA receptor 1 94.84 High High
gABA 11 94.72 High High
Disease Link Frequency Relevance Heat
Pain 24 99.24 Very High Very High Very High
Bordatella Infection 1 92.08 High High
Nociception 25 89.12 High High
Urological Neuroanatomy 18 64.80 Quite High
Depression 2 62.40 Quite High
Stress 12 42.88 Quite Low
Hypotension 1 38.84 Quite Low
Polycystic Ovary Syndrome 7 37.40 Quite Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results show that activation of GABAB receptors decreased GABAA receptor-mediated synaptic input to cerebellar Purkinje cells both by lowering the firing rate of the inhibitory input neurons and by inhibiting GABA release from their axon terminals with a presynaptic mechanism.
Negative_regulation (decreased) of Positive_regulation (activation) of GABAB in Purkinje cells associated with gaba
1) Confidence 0.36 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12059965 Disease Relevance 0.06 Pain Relevance 0.39
The absence of tonic GABAB activation on SPNs has also been reported using a splanchnic nerveĀ–spinal cord preparation (Cheng et al., 2005).


Negative_regulation (absence) of Positive_regulation (activation) of GABAB in spinal cord associated with spinal cord
2) Confidence 0.20 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.12 Pain Relevance 0.36
In PTX-treated slices the frequency decrease due to GABAB, mu-opioid, and alpha 2-adrenergic receptor activation was attenuated (P < or = 0.05), whereas the SP receptor-mediated response was unaltered.
Negative_regulation (decrease) of Positive_regulation (activation) of GABAB associated with opioid and substance p
3) Confidence 0.04 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8806921 Disease Relevance 0.09 Pain Relevance 0.62
After 21 days of treatment the decrease in pain-like behaviour was correlated with a decrease in CGRP and an increase in GABAB2 receptors in the spinal cord of CORT and DEX treated-animals.
Negative_regulation (decrease) of Positive_regulation (increase) of GABAB2 in spinal cord associated with pain, dexamethasone, spinal cord and calcitonin gene-related peptide
4) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.35 Pain Relevance 0.97

General Comments

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