INT6459

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Context Info
Confidence 0.53
First Reported 1984
Last Reported 1997
Negated 7
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.16
Pain Relevance 6.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
tail 2
brain 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 17 100.00 Very High Very High Very High
Clonidine 12 100.00 Very High Very High Very High
Serotonin 4 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
opiate 11 99.84 Very High Very High Very High
Morphine 19 99.82 Very High Very High Very High
bradykinin 3 99.60 Very High Very High Very High
antinociception 6 99.56 Very High Very High Very High
tail-flick 2 99.46 Very High Very High Very High
Antinociceptive 5 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1 87.16 High High
Ganglion Cysts 1 76.68 Quite High
Pain 1 30.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Single s.c. injections of the 5-hydroxytryptamine (5-HT)1A receptor agonists buspirone at 4 mg/kg, 8-hydroxy-2-(di-n-propylamino)tetralin at 1 or 4 mg/kg or ipsapirone at 10 mg/kg did not affect 5-HT inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes.
Neg (not) Regulation (affect) of Negative_regulation (inhibition) of cyclase associated with agonist
1) Confidence 0.53 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1530973 Disease Relevance 0 Pain Relevance 0.38
These results suggest that measurements of cyclic AMP released from brain slices do not accurately reflect effects on adenylate cyclase inhibition by opiates.
Neg (not) Regulation (effects) of Negative_regulation (inhibition) of cyclase in brain associated with opiate
2) Confidence 0.53 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 3022183 Disease Relevance 0 Pain Relevance 0.57
The effect of inhibition of nitric oxide synthesis and guanylate cyclase on the peripheral antinociceptive effect of morphine was assessed by using the formalin test in the rat.
Regulation (effect) of Negative_regulation (inhibition) of cyclase associated with antinociceptive and morphine
3) Confidence 0.39 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9537812 Disease Relevance 0 Pain Relevance 0.56
The EGTA treatment did not affect the kappa agonist inhibition of the forskolin-stimulated cyclase.
Neg (not) Regulation (affect) of Negative_regulation (inhibition) of cyclase associated with agonist
4) Confidence 0.11 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2536070 Disease Relevance 0.08 Pain Relevance 1.18
It is proposed that the inhibitory action of clonidine upon insulin release is attributable, in part at least, to inhibition of adenylate cyclase.
Regulation (attributable) of Negative_regulation (inhibition) of cyclase associated with clonidine
5) Confidence 0.05 Published 1984 Journal Biosci. Rep. Section Abstract Doc Link 6087950 Disease Relevance 0.09 Pain Relevance 0.64
Maximal inhibition of adenylate cyclase achieved by incubation with AAGTP was not altered by low pH pretreatment.
Neg (not) Regulation (altered) of Negative_regulation (inhibition) of cyclase
6) Confidence 0.04 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2498464 Disease Relevance 0 Pain Relevance 0.11
The effect of intrathecal pretreatment with forskolin and the phosphodiesterase inhibitors Ro 20-1724, rolipram and 3-isobutyl-1-methylxanthine (IBMX) on the antinociceptive action of morphine administered intrathecally was examined using the rat tail-flick test to determine whether inhibition of adenylate cyclase contributed to spinal antinociception.
Spec (whether) Regulation (contributed) of Spec (whether) Negative_regulation (inhibition) of cyclase in tail associated with antinociception, tail-flick, antinociceptive, morphine and intrathecal
7) Confidence 0.03 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1714608 Disease Relevance 0 Pain Relevance 0.97
L-NMMA as well as the inhibitor of guanylate cyclase methylene blue (10(-5) M) prevented the relaxations induced by clonidine, reduced those to serotonin, but hardly affected those to bradykinin.
Regulation (affected) of Negative_regulation (inhibitor) of guanylate cyclase associated with bradykinin, serotonin and clonidine
8) Confidence 0.03 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1992790 Disease Relevance 0 Pain Relevance 0.63
In transfected cells expressing mGluR2, AIDA (< or = 1 mM) did not affect the inhibition of forskolin-stimulated adenylate cyclase activity induced by (1S,3R)-ACPD, but at large concentrations, it displayed a modest agonist activity.
Neg (not) Regulation (affect) of Negative_regulation (inhibition) of cyclase associated with agonist
9) Confidence 0.02 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152378 Disease Relevance 0 Pain Relevance 0.29
In concentrations that antagonized the presynaptic inhibitory effect of [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAMGO) on [3H]norepinephrine release from rat neocortical slices, the cyclic somatostatin-related mu opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 did not affect the inhibition of dopamine-sensitive adenylate cyclase caused by DAMGO in neostriatal slices.
Neg (not) Regulation (affect) of Negative_regulation (inhibition) of cyclase associated with dopamine, antagonist, mu opioid receptor, somatostatin and enkephalin
10) Confidence 0.02 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1328606 Disease Relevance 0 Pain Relevance 0.63
Under these conditions, both Gpp(NH)p- and morphine-induced inhibition of adenylate cyclase were independent of Ca2+/CaM.
Neg (independent) Regulation (independent) of Negative_regulation (inhibition) of cyclase associated with morphine
11) Confidence 0.01 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3625205 Disease Relevance 0 Pain Relevance 0.48

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