INT6460

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Context Info
Confidence 0.52
First Reported 1984
Last Reported 2006
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.19
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
pancreatic islets 2
spinal cord 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 8 100.00 Very High Very High Very High
Neurotransmitter 1 99.54 Very High Very High Very High
Hyperalgesia 2 99.40 Very High Very High Very High
Spinal cord 8 98.92 Very High Very High Very High
Inflammation 7 98.88 Very High Very High Very High
narcan 1 98.54 Very High Very High Very High
Versed 2 95.28 Very High Very High Very High
isoflurane 2 94.56 High High
agonist 1 94.16 High High
anesthesia 2 93.68 High High
Disease Link Frequency Relevance Heat
Natriuresis 10 100.00 Very High Very High Very High
Hyperalgesia 3 99.40 Very High Very High Very High
INFLAMMATION 4 98.88 Very High Very High Very High
Coronary Heart Disease 8 95.84 Very High Very High Very High
Fibrosis 4 91.24 High High
Nociception 1 68.40 Quite High
Cancer 1 60.64 Quite High
Inflammatory Pain 1 60.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ANG II type 1 receptor was blocked with losartan (10 mg.kg(-1).day(-1)) to investigate a possible role of the renin-angiotensin system in regulation of natriuretic peptide and NPR gene expression.
Spec (possible) Regulation (role) of Gene_expression (expression) of NPR associated with natriuresis
1) Confidence 0.52 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.91 Pain Relevance 0.28
However, the expression and function of the NO receptor, soluble guanylate cyclase, is not fully understood in this processing at the spinal cord level.
Neg (not) Regulation (understood) of Gene_expression (expression) of cyclase in spinal cord associated with spinal cord
2) Confidence 0.38 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044461 Disease Relevance 0.33 Pain Relevance 0.49
The ANG II type 1 receptor was blocked with losartan (10 mg.kg(-1).day(-1)) to investigate a possible role of the renin-angiotensin system in regulation of natriuretic peptide and NPR gene expression.
Regulation (regulation) of Gene_expression (expression) of NPR associated with natriuresis
3) Confidence 0.23 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.90 Pain Relevance 0.27
Inhibitory effect of clonidine upon adenylate cyclase activity, cyclic AMP production, and insulin release in rat pancreatic islets.
Regulation (effect) of Gene_expression (production) of cyclase in pancreatic islets associated with clonidine
4) Confidence 0.05 Published 1984 Journal Biosci. Rep. Section Title Doc Link 6087950 Disease Relevance 0.06 Pain Relevance 0.59
In striking contrast to D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 and naltrindole, naloxone did not discriminate between the neurotransmitter release-and adenylate cyclase-inhibitory effects of DAMGO and [D-Ser2(O-tert-butyl), Leu5]enkephalyl-Thr6.
Regulation (effects) of Gene_expression (inhibitory) of cyclase associated with neurotransmitter and narcan
5) Confidence 0.02 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1328606 Disease Relevance 0 Pain Relevance 0.49

General Comments

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