INT64609

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.64
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLXNA3) plasma membrane (PLXNA3) intracellular (PLXNA3)
Anatomy Link Frequency
body 1
PLXNA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 98.16 Very High Very High Very High
Opioid 15 97.80 Very High Very High Very High
transdermal 6 97.48 Very High Very High Very High
Calcitonin gene-related peptide 1 92.00 High High
agonist 1 91.68 High High
cINOD 1 88.80 High High
corticosteroid 1 85.60 High High
depression 1 81.60 Quite High
Pain 5 80.00 Quite High
Hyperalgesia 1 79.20 Quite High
Disease Link Frequency Relevance Heat
Eye Disease 2 99.84 Very High Very High Very High
Aging 1 99.48 Very High Very High Very High
Hot Flashes 9 99.42 Very High Very High Very High
INFLAMMATION 2 98.16 Very High Very High Very High
Disease 3 97.72 Very High Very High Very High
Disorders Of The Lacrimal System 3 97.40 Very High Very High Very High
Endometriosis (extended) 4 94.96 High High
Porphyria 4 94.16 High High
Reprotox - General 2 4 93.32 High High
Reprotox - General 1 4 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of escalating cyclical premenstrual attacks, the following 2 years, depletion of the endogenous sex hormone was considered as haeme arginate treatment proved insufficient.
Negative_regulation (depletion) of sex
1) Confidence 0.57 Published 2002 Journal J. Intern. Med. Section Abstract Doc Link 12270008 Disease Relevance 0.52 Pain Relevance 0.23
The hot flashes are most likely caused by a reduction in sex-hormone levels, which, in turn, causes an instability in the hypothalamic thermoregulatory center.
Negative_regulation (reduction) of sex associated with hot flashes
2) Confidence 0.57 Published 2003 Journal J Support Oncol Section Abstract Doc Link 15334868 Disease Relevance 0.94 Pain Relevance 0.18
A decline in systemic and local levels of sex hormones is associated with advancing age and advancing disease.
Negative_regulation (decline) of sex associated with disease
3) Confidence 0.57 Published 2008 Journal Drugs Aging Section Abstract Doc Link 18257598 Disease Relevance 1.09 Pain Relevance 0.18
As ageing progresses the levels of sex hormones decrease in the human body.
Negative_regulation (decrease) of sex in body associated with aging
4) Confidence 0.41 Published 1996 Journal J Clin Pharm Ther Section Abstract Doc Link 8809647 Disease Relevance 0.53 Pain Relevance 0.08
PERSPECTIVE: These observations demonstrate profound inhibition of ovarian sex hormone and adrenal androgen production among women chronically consuming sustained-action opioids.
Negative_regulation (inhibition) of sex associated with opioid
5) Confidence 0.41 Published 2008 Journal J Pain Section Abstract Doc Link 17936076 Disease Relevance 0.55 Pain Relevance 1.27

General Comments

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