INT6461

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 35
Total Number 37
Disease Relevance 10.38
Pain Relevance 17.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
spinal cord 5
pituitary 5
BNP 3
neuronal 3
neurons 3
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 16 100.00 Very High Very High Very High
opiate 12 100.00 Very High Very High Very High
Morphine 13 99.84 Very High Very High Very High
Calcitonin gene-related peptide 8 99.84 Very High Very High Very High
Spinal cord 92 99.68 Very High Very High Very High
dorsal root ganglion 26 99.68 Very High Very High Very High
Clonidine 9 99.68 Very High Very High Very High
nMDA receptor 7 99.64 Very High Very High Very High
Inflammation 34 99.60 Very High Very High Very High
Neuropeptide 5 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 30 100.00 Very High Very High Very High
INFLAMMATION 18 99.60 Very High Very High Very High
Hyperalgesia 24 99.40 Very High Very High Very High
Ganglion Cysts 26 99.20 Very High Very High Very High
Generalized Anxiety Disorder 4 99.20 Very High Very High Very High
Depression 1 98.92 Very High Very High Very High
Coronary Heart Disease 36 98.72 Very High Very High Very High
Inflammatory Pain 10 98.44 Very High Very High Very High
Opiate Addiction 5 97.08 Very High Very High Very High
Pain 11 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry showed that BNP was expressed in calcitonin gene-related peptide (CGRP)-containing small neurons and IB4 (isolectin B4)-positive neurons, whereas NPR-A was present in CGRP-containing neurons.
Gene_expression (present) of NPR-A in neurons associated with calcitonin gene-related peptide
1) Confidence 0.75 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.88 Pain Relevance 0.64
Using microarray and immunoblot analyses, we found that BNP and NPR-A were expressed in the dorsal root ganglion (DRG) of rats and upregulated after intraplantar injection of complete Freund's adjuvant (CFA).
Gene_expression (expressed) of NPR-A in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.75 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.85 Pain Relevance 0.53
The ANG II type 1 receptor was blocked with losartan (10 mg.kg(-1).day(-1)) to investigate a possible role of the renin-angiotensin system in regulation of natriuretic peptide and NPR gene expression.
Gene_expression (expression) of NPR associated with natriuresis
3) Confidence 0.66 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.89 Pain Relevance 0.27
Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.
Gene_expression (expression) of natriuretic peptide receptor associated with natriuresis and coronary heart disease
4) Confidence 0.66 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 16272201 Disease Relevance 0.90 Pain Relevance 0.23
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Gene_expression (expression) of NPR in BNP
5) Confidence 0.65 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.82 Pain Relevance 0.26
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Gene_expression (expression) of NPR in BNP
6) Confidence 0.65 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.82 Pain Relevance 0.26
However, the expression and function of the NO receptor, soluble guanylate cyclase, is not fully understood in this processing at the spinal cord level.
Gene_expression (expression) of cyclase in spinal cord associated with spinal cord
7) Confidence 0.65 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044461 Disease Relevance 0.32 Pain Relevance 0.46
During formalin-induced long-lasting inflammation, we found that the expression of the alpha(1) subunit of soluble guanylate cyclase was dramatically increased in the lumbar spinal cord on the second and fourth days after formalin injection into the dorsal side of a hind paw.
Gene_expression (expression) of cyclase in spinal cord associated with inflammation and spinal cord
8) Confidence 0.65 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044461 Disease Relevance 0.54 Pain Relevance 0.74
The present results indicate that peripheral inflammation not only initially activates but also later up-regulates soluble guanylate cyclase expression via the NMDA receptor-NO signaling pathway, suggesting that soluble guanylate cyclase might be involved in the central mechanism of formalin-induced inflammatory hyperalgesia in the spinal cord.
Gene_expression (expression) of cyclase in spinal cord associated with hyperalgesia, inflammation, nmda receptor and spinal cord
9) Confidence 0.65 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044461 Disease Relevance 0.57 Pain Relevance 0.75
In the present study, we report that the soluble guanylate cyclase alpha(1) subunit but not the beta(1) subunit was expressed in rat spinal cord, particularly in the dorsal horn.
Neg (not) Gene_expression (expressed) of cyclase in dorsal horn associated with dorsal horn and spinal cord
10) Confidence 0.65 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044461 Disease Relevance 0.40 Pain Relevance 0.55
Our results suggest the existence of a peripheral trace of inflammatory pain, a phenomenon which may be associated with stimulation of neuronal adenylate cyclase and protein synthesis.
Gene_expression (synthesis) of cyclase in neuronal associated with ipn
11) Confidence 0.51 Published 1990 Journal Pain Section Abstract Doc Link 2174528 Disease Relevance 0.42 Pain Relevance 0.77
These results indicate a dual regulation of guanylate cyclase and adenylate cyclase by the alpha 2-receptor signal: guanylate cyclase is coupled to the receptor in a positive fashion, whereas adenylate cyclase is coupled in a negative fashion.
Neg (negative) Gene_expression (coupled) of cyclase
12) Confidence 0.50 Published 1986 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2875690 Disease Relevance 0.13 Pain Relevance 0.28
No change in cortical cholecystokinin (CCK), ENK, glutamic acid decarboxylase (GAD) and somatostatin (SRIF) expression, in striatal GAD, SRIF, nitric oxide synthase (NOS) and guanylate cyclase expression, and in thalamic CCK, GAD and thyrotropin-releasing hormone expression was found.
Gene_expression (expression) of guanylate cyclase associated with generalized anxiety disorder, somatostatin, enkephalin and cholecystokinin
13) Confidence 0.33 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12865138 Disease Relevance 0.54 Pain Relevance 0.83
These results suggest that acetylcholine evoked production of a nitrosyl factor in capsaicin-sensitive (small diameter) sensory neurons, which subsequently stimulated a soluble guanylate cyclase and cyclic GMP production in adjacent neuronal and/or non-neuronal cells.
Gene_expression (production) of cyclase in neuronal associated with qutenza
14) Confidence 0.31 Published 1994 Journal Neuroscience Section Abstract Doc Link 7530344 Disease Relevance 0.09 Pain Relevance 0.45
In one series, the effect of 250 mg/kg of ODQ on neuronal cyclase guanosine monophosphate production was determined by microdialysis.
Gene_expression (production) of neuronal cyclase in neuronal
15) Confidence 0.27 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15333406 Disease Relevance 0 Pain Relevance 0.58
In conclusion pituitary adenylate cyclase activating peptide is present in the rat urinary tract mainly in the form of pituitary adenylate cyclase activating peptide-38.
Gene_expression (present) of cyclase in pituitary
16) Confidence 0.24 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0 Pain Relevance 0.35
When extracts from the urinary bladder were fractionated by reverse phase high pressure liquid chromatography immunoreactive components corresponding to synthetic pituitary adenylate cyclase activating peptide-38, pituitary adenylate cyclase activating peptide-27 and pituitary adenylate cyclase activating peptide-related peptide were identified with the respective antisera.
Gene_expression (synthetic) of cyclase in pituitary
17) Confidence 0.21 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0.09 Pain Relevance 0.07
When extracts from the urinary bladder were fractionated by reverse phase high pressure liquid chromatography immunoreactive components corresponding to synthetic pituitary adenylate cyclase activating peptide-38, pituitary adenylate cyclase activating peptide-27 and pituitary adenylate cyclase activating peptide-related peptide were identified with the respective antisera.
Gene_expression (synthetic) of cyclase in pituitary
18) Confidence 0.21 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0.09 Pain Relevance 0.07
In conclusion pituitary adenylate cyclase activating peptide is present in the rat urinary tract mainly in the form of pituitary adenylate cyclase activating peptide-38.
Gene_expression (present) of cyclase in pituitary
19) Confidence 0.21 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0 Pain Relevance 0.35
Therefore, in nucleus accumbens opioids may inhibit DA-sensitive adenylate cyclase through activation of a mu/delta-opioid receptor complex, whereas in olfactory tubercle mu-receptors appear to mediate the inhibition of adenylate cyclase activity.
Spec (appear) Gene_expression (appear) of cyclase in olfactory tubercle associated with nucleus accumbens, dopamine, opioid receptor and opioid
20) Confidence 0.19 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0 Pain Relevance 1.09

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