INT64636

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2011
Negated 5
Speculated 13
Reported most in Abstract
Documents 242
Total Number 255
Disease Relevance 147.52
Pain Relevance 79.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 22
spinal cord 18
microglia 16
RAW 264 13
liver 12
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1548 100.00 Very High Very High Very High
cytokine 827 100.00 Very High Very High Very High
Spinal cord 425 100.00 Very High Very High Very High
Dorsal horn 281 100.00 Very High Very High Very High
Arthritis 71 100.00 Very High Very High Very High
COX2 70 100.00 Very High Very High Very High
Sciatic nerve 59 100.00 Very High Very High Very High
Inflammatory marker 8 100.00 Very High Very High Very High
Peripheral nervous system 5 100.00 Very High Very High Very High
Thoracotomy 552 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1919 100.00 Very High Very High Very High
Injury 667 100.00 Very High Very High Very High
Apoptosis 513 100.00 Very High Very High Very High
Lung Injury 187 100.00 Very High Very High Very High
Arthritis 135 100.00 Very High Very High Very High
Necrosis 95 100.00 Very High Very High Very High
Cancer 90 100.00 Very High Very High Very High
Urological Neuroanatomy 40 100.00 Very High Very High Very High
Functional Bowel Disorder 18 100.00 Very High Very High Very High
Autoimmune Disease 9 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial study using rats shows that morphine-6beta-glucuronide administration (0, 1.0, 3.163, 10 mg/kg s.c.) results in a pronounced reduction in lipopolysaccharide (LPS)-induced expression of iNOS (inducible nitricoxide synthease) in spleen, lung, and liver tissue as measured by western blotting.
Positive_regulation (induced) of Gene_expression (expression) of iNOS in liver associated with morphine
1) Confidence 0.70 Published 2001 Journal Inflammation Section Abstract Doc Link 11580103 Disease Relevance 0 Pain Relevance 0.88
The results suggest that local NO production by activation of iNOS mRNA expression and cytokine release may contribute to LPS-induced organ dysfunction at various time points.
Positive_regulation (activation) of Gene_expression (expression) of iNOS mRNA associated with cytokine
2) Confidence 0.70 Published 2006 Journal Life Sci. Section Abstract Doc Link 16181643 Disease Relevance 0.28 Pain Relevance 0.17
There was also a discernible elevation of iNOS expression in the ventrolateral medulla, followed by a massive production of nitrotyrosine, an experimental index for peroxynitrite.
Positive_regulation (elevation) of Gene_expression (expression) of iNOS in medulla associated with medulla
3) Confidence 0.70 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384174 Disease Relevance 0.35 Pain Relevance 0.44
The purpose of this study was to investigate the peripheral influences of US and phonophoresis on the modulation of spinal inducible nitric oxide synthase (iNOS) expression elicited by hind paw stimulation with an ankle injection of complete Freund adjuvant (CFA).
Positive_regulation (elicited) of Gene_expression (expression) of iNOS in ankle associated with freund adjuvant
4) Confidence 0.70 Published 2006 Journal Phys Ther Section Abstract Doc Link 16386061 Disease Relevance 0.33 Pain Relevance 0.33
These results demonstrate that submillimolar doses of two commonly used local anesthetics can increase glial NOS2 expression.
Positive_regulation (increase) of Gene_expression (expression) of NOS2 associated with local anesthetic
5) Confidence 0.70 Published 2001 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 11294465 Disease Relevance 0.05 Pain Relevance 0.35
These results provide evidence for induction of NOS II expression under conditions producing thermal hyperalgesia and suggest a possible role in this behavior for the production of NO by a variety of cell types in the CNS.
Positive_regulation (induction) of Gene_expression (expression) of NOS II associated with thermal hyperalgesia
6) Confidence 0.69 Published 1996 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8811427 Disease Relevance 0.30 Pain Relevance 0.63
Dexamethasone decreased cytokine-induced NF-kappaB activation and iNOS mRNA expression, but neither salicylate nor aspirin affected NF-kappaB activation or iNOS mRNA expression.
Positive_regulation (induced) of Gene_expression (expression) of iNOS mRNA associated with aspirin, dexamethasone and cytokine
7) Confidence 0.69 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.42 Pain Relevance 0.69
CONCLUSIONS: This study provides the first evidence that heroin-induced alteration of iNOS expression can be conditioned to environmental stimuli, and suggest that environmental stimuli associated with drug use may contribute to the alteration in susceptibility to infection.


Positive_regulation (induced) of Gene_expression (expression) of iNOS
8) Confidence 0.69 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457272 Disease Relevance 0 Pain Relevance 0
Shear stress stimulates inducible nitric oxide synthase (iNOS) expression in cultured smooth muscle cells (12).
Positive_regulation (stimulates) of Gene_expression (expression) of iNOS in smooth muscle cells associated with stress
9) Confidence 0.69 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526521 Disease Relevance 1.68 Pain Relevance 0.20
Immunohistochemistry showed increased inducible nitric oxide synthase (iNOS) expression in mononuclear cells accumulated in the interstitium in the injury group.
Positive_regulation (increased) of Gene_expression (expression) of iNOS in mononuclear cells associated with injury
10) Confidence 0.69 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2526521 Disease Relevance 1.16 Pain Relevance 0.30
The expression of iNOS and TLR4 in the intestine was enhanced in arthritic rats as compared with normal rats.
Positive_regulation (enhanced) of Gene_expression (expression) of iNOS in intestine associated with arthritis
11) Confidence 0.69 Published 2007 Journal Life Sci. Section Abstract Doc Link 17920637 Disease Relevance 0.81 Pain Relevance 0.26
The iNOS protein expression was induced at 4 h after i.t.
Positive_regulation (induced) of Gene_expression (expression) of iNOS
12) Confidence 0.69 Published 2004 Journal Brain Res. Section Abstract Doc Link 15223378 Disease Relevance 0.52 Pain Relevance 0.68
The present study was performed to investigate whether increases in nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) were involved in impairment of learning behavior and hippocampal long-term potentiation (LTP) following transient ischemia.
Spec (whether) Positive_regulation (increases) of Gene_expression (production) of iNOS associated with ischemia and long-term potentiation
13) Confidence 0.69 Published 2001 Journal Behav. Brain Res. Section Abstract Doc Link 11182164 Disease Relevance 0.17 Pain Relevance 0.33
Exposure to 60 min of 2.1% isoflurane inhalation with oxygen 24 h before ischemia significantly reduced I/R-induced myocardial infarct size that was associated with overexpression of iNOS protein and increased NO content in the heart.
Positive_regulation (overexpression) of Gene_expression (overexpression) of iNOS protein in heart associated with ischemia, isoflurane and myocardial infarction
14) Confidence 0.68 Published 2008 Journal Shock Section Abstract Doc Link 18708911 Disease Relevance 0.27 Pain Relevance 0.33
We report that CCI injury induced local iNOS expression in both macrophages and Schwann cells within and distal to the injury site.
Positive_regulation (induced) of Gene_expression (expression) of iNOS in Schwann cells associated with eae and injury
15) Confidence 0.61 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10076904 Disease Relevance 1.04 Pain Relevance 0.69
Two previous studies reported that iNOS expression was increased in Barrett's esophagus-associated neoplastic progression in human and rat (10, 12).
Positive_regulation (increased) of Gene_expression (expression) of iNOS in esophagus
16) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.31 Pain Relevance 0
Takahashi et al. also found that iNOS expression was increased in rat colon tumors induced by azoxymethane (11).
Positive_regulation (increased) of Gene_expression (expression) of iNOS in colon associated with colon cancer
17) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.77 Pain Relevance 0.03
The present study demonstrates that 1) inhibitory effect of dexamethasone on cytokine-induced iNOS expression and NO production in rat VSMCs, although potentially acting at multiple levels, is partly mediated by inhibition of NF-kappaB activation resulting from decreased phosphorylation and degradation of IkappaB-alpha, 2) both salicylate and aspirin inhibit cytokine-stimulated NO production at translational and/or posttranslational levels without affecting NF-kappaB- mediated iNOS gene expression, and 3) aspirin directly inhibits iNOS enzyme activity.
Neg (NO) Positive_regulation (induced) of Gene_expression (expression) of iNOS associated with aspirin, dexamethasone and cytokine
18) Confidence 0.60 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.10 Pain Relevance 0.71
Indomethacin decreased prostaglandin E2 (PGE2) production in the intestinal mucosa and caused intestinal hypermotility and bacterial invasion as well as the upregulation of iNOS expression and NO production, resulting in hemorrhagic lesions.
Positive_regulation (upregulation) of Gene_expression (expression) of iNOS in PGE2 associated with functional bowel disorder
19) Confidence 0.60 Published 2006 Journal Dig. Dis. Sci. Section Abstract Doc Link 16944022 Disease Relevance 0.40 Pain Relevance 0.59
The rats then were re-exposed to the conditioning chamber in the absence of heroin and immediately following the session were injected subcutaneously with lipopolysaccharide (LPS) to induce iNOS expression.
Positive_regulation (induce) of Gene_expression (expression) of iNOS
20) Confidence 0.60 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12457272 Disease Relevance 0 Pain Relevance 0

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