INT64667

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.31
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SCG2) extracellular region (SCG2) intracellular (SCG2)
Anatomy Link Frequency
sputum 1
medial 1
skin 1
SCG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 27 100.00 Very High Very High Very High
Enkephalin 2 98.12 Very High Very High Very High
c fibre 4 97.84 Very High Very High Very High
substance P 6 97.72 Very High Very High Very High
qutenza 5 97.04 Very High Very High Very High
Nucleus accumbens 1 91.84 High High
Inflammation 5 91.04 High High
amygdala 4 86.12 High High
fibrosis 2 85.72 High High
Inflammatory response 1 73.92 Quite High
Disease Link Frequency Relevance Heat
Stress 7 97.40 Very High Very High Very High
INFLAMMATION 5 91.04 High High
Injury 2 89.00 High High
Mucositis 1 88.16 High High
Fibrosis 1 85.72 High High
Cirrhosis 1 84.60 Quite High
Atherosclerosis 2 83.40 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 67.12 Quite High
Functional Bowel Disorder 1 66.92 Quite High
Wound Healing 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secretoneurin is a newly discovered 33-amino acid neuropeptide derived from secretogranin II (chromogranin C), which is found in sensory afferent C-fibers.
Positive_regulation (derived) of secretogranin II associated with c fibre and neuropeptide
1) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8813595 Disease Relevance 0.18 Pain Relevance 0.34
The attraction of human skin fibroblasts toward secretoneurin could be blocked by specific anti-secretoneurin antibodies and is mediated by the C-terminal fragment of the peptide.
Positive_regulation (mediated) of secretoneurin in skin
2) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8813595 Disease Relevance 0.16 Pain Relevance 0.34
A high concentration of secretoneurin immunoreactivity was also observed in the central and medial amygdaloid nuclei.
Positive_regulation (concentration) of secretoneurin in medial
3) Confidence 0.50 Published 1997 Journal Synapse Section Abstract Doc Link 9131771 Disease Relevance 0 Pain Relevance 0.41
Bronchial histamine challenge increased the sputum levels of secretoneurin (P <0.05).
Positive_regulation (increased) of secretoneurin in sputum
4) Confidence 0.47 Published 2005 Journal Allergy Section Body Doc Link 15727576 Disease Relevance 0 Pain Relevance 0
Secretoneurin (SN), a 33-amino acid neuropeptide, is derived from secretogranin II that is released from sensory afferent C-fibers by capsaicin.
Positive_regulation (derived) of Secretoneurin associated with c fibre, qutenza and neuropeptide
5) Confidence 0.40 Published 1998 Journal Blood Section Abstract Doc Link 9473216 Disease Relevance 0 Pain Relevance 0.44
Secretoneurin (SN), a novel 33-amino acid neuropeptide derived from secretogranin II (chromogranin C), is widely distributed in the central and peripheral nervous and neuroendocrine systems, including afferent C-fibers, and can be released in the periphery by capsaicin.
Positive_regulation (derived) of secretogranin II associated with c fibre, qutenza and neuropeptide
6) Confidence 0.38 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351368 Disease Relevance 0.33 Pain Relevance 0.49
Secretogranin II - the secretoneurin precursor - was induced by MD.
Positive_regulation (induced) of secretoneurin
7) Confidence 0.08 Published 2008 Journal Journal of proteomics Section Abstract Doc Link 18541476 Disease Relevance 0.58 Pain Relevance 0.11

General Comments

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