INT64668

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 0.54
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
Anatomy Link Frequency
nervous system 1
reticulum 1
melanotrope 1
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 100.00 Very High Very High Very High
analgesia 3 99.72 Very High Very High Very High
Analgesic 12 99.44 Very High Very High Very High
Kappa opioid receptor 3 99.34 Very High Very High Very High
narcan 6 98.74 Very High Very High Very High
Opioid 7 98.68 Very High Very High Very High
opioid receptor 7 98.12 Very High Very High Very High
antidepressant 5 97.86 Very High Very High Very High
antagonist 4 96.92 Very High Very High Very High
fortral 26 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1 94.92 High High
Cancer 2 92.36 High High
Retina Disease 1 91.92 High High
Drug Dependence 1 91.04 High High
Psychosis 1 90.40 High High
Schizophrenia 1 80.24 Quite High
Vibrio Infection 2 25.00 Low Low
Affective Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a radiolabeled chemical probe, we here purified a target of SR 31747A and called it SR 31747A-binding protein (SR-BP).
Regulation (target) of SR-BP
1) Confidence 0.60 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341151 Disease Relevance 0 Pain Relevance 0
Using a radiolabeled chemical probe, we here purified a target of SR 31747A and called it SR 31747A-binding protein (SR-BP).
Regulation (target) of SR 31747A-binding protein
2) Confidence 0.44 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341151 Disease Relevance 0 Pain Relevance 0
The selective binding of sphingosine but not sphingosine-1 phosphate to the sigma1 receptor suggests a mechanism for regulation of sigma1 receptor activity by the sphingosine kinase.
Regulation (regulation) of sigma1 receptor
3) Confidence 0.40 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.11
Similarly, the antisense probe targeting the sigma1 receptor enhanced the analgesic activity of the kappa1-opioid receptor agonist U50,488H (trans-3,4-dichloro-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeacetamidel++ +) and the kappa3-opioid receptor agonist naloxone benzoylhydrazone.
Regulation (targeting) of sigma1 receptor associated with analgesic, narcan, agonist and opioid receptor
4) Confidence 0.38 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274937 Disease Relevance 0 Pain Relevance 0.84
The antidepressant-like effect induced by sigma-1 receptor agonists may involve intracellular Ca (2+) mobilization such that sigma-1 receptor agonists modulate Ca (2+) release from endoplasmic reticulum (ER) in a cytoskeletal protein-dependent manner.
Regulation (modulate) of sigma-1 receptor in reticulum associated with antidepressant and agonist
5) Confidence 0.36 Published 2004 Journal Pharmacopsychiatry Section Abstract Doc Link 15547787 Disease Relevance 0.09 Pain Relevance 0.55
Based on the structure of fenpropimorph, a high affinity (K(i)=0.005 nM)(1) sigma-1 receptor ligand and strong inhibitor of the yeast sterol isomerase (ERG2), we previously deduced a basic sigma-1 receptor pharmacophore or chemical backbone composed of a phenyl ring attached to a di-substituted nitrogen atom via an alkyl chain.(2) Here, we report the design and synthesis of various N,N-dialkyl or N-alkyl-N-aralkyl derivatives based on this pharmacophore as well as their binding affinities to the sigma-1 receptor.
Regulation (attached) of sigma-1 receptor
6) Confidence 0.21 Published 2010 Journal Bioorg. Med. Chem. Section Abstract Doc Link 20493718 Disease Relevance 0.37 Pain Relevance 0.13
Enhanced kappa-opioid receptor-mediated analgesia by antisense targeting the sigma1 receptor.
Regulation (targeting) of sigma1 receptor associated with analgesic, kappa opioid receptor and analgesia
7) Confidence 0.17 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9274937 Disease Relevance 0 Pain Relevance 0.98
In the current study, we used an antisense oligodeoxynucleotide targeting the recently cloned sigma1 receptor to assess its functions within the nervous system.
Regulation (targeting) of sigma1 receptor in nervous system
8) Confidence 0.17 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274937 Disease Relevance 0 Pain Relevance 0.74
Furthermore, the Bmax value for sigma 1 sites in Pellet 2 did not change, whereas the sigma 2 Bmax increased 1.8 fold relative to the original P2 membranes.
Neg (not) Regulation (change) of sigma 1
9) Confidence 0.13 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8813603 Disease Relevance 0 Pain Relevance 0.06
Gramicidin perforated patch-clamp recordings were used to study the effects of two sigma 1 receptor ligands, (+)-N-cyclopropylmethyl-N-methyl-1, 4-diphenyl-1-ethyl-but-3-en-1-ylamine hydrochloride (JO 1784) and (+)-pentazocine, on the transient outward potassium current (IA) in cultured frog melanotrope cells. (+)-Pentazocine reversibly decreased the current amplitude in a dose-dependent manner.
Regulation (effects) of sigma 1 receptor in melanotrope associated with fortral
10) Confidence 0.10 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087020 Disease Relevance 0 Pain Relevance 0.29
However, while the sigma 1 and sigma 2 Bmax values in extracts and pellets were generally on the same order as those of P2 membranes, the actual sigma 2 to sigma 1 Bmax ratio varied markedly across the fractions.
Regulation (values) of sigma 1
11) Confidence 0.09 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8813603 Disease Relevance 0 Pain Relevance 0.07
The changes in sigma 2/ sigma 1 binding ratio in extracts were observed using two different assay methods for soluble receptors (retention on polyethyleneimine-coated filters and polyethylene glycol precipitation) and is therefore not an artifact of assay procedure.
Regulation (changes) of sigma 1
12) Confidence 0.06 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8813603 Disease Relevance 0 Pain Relevance 0.05
The treatment with haloperidol also did not affect sigma 1-receptor mRNA detected by the RNase protection assay.
Neg (not) Regulation (affect) of sigma 1
13) Confidence 0.03 Published 1999 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 10562966 Disease Relevance 0.08 Pain Relevance 0.08

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