INT64671

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.19
Pain Relevance 6.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NISCH) plasma membrane (NISCH) cytoplasm (NISCH)
Anatomy Link Frequency
ovary 5
PC-12 1
brain 1
NISCH (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 15 100.00 Very High Very High Very High
agonist 5 99.68 Very High Very High Very High
Nerve growth factor 2 98.52 Very High Very High Very High
addiction 35 98.40 Very High Very High Very High
Morphine 59 98.18 Very High Very High Very High
Calcium channel 6 97.44 Very High Very High Very High
narcan 24 96.52 Very High Very High Very High
Opioid 9 95.76 Very High Very High Very High
Clonidine 4 94.20 High High
antagonist 6 83.12 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 2 98.52 Very High Very High Very High
Morphine Dependence 28 98.40 Very High Very High Very High
Opiate Addiction 7 96.20 Very High Very High Very High
Hypertension 2 82.80 Quite High
Stroke 1 71.60 Quite High
Left Ventricular Hypertrophy 1 67.52 Quite High
Insulin Resistance 1 60.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two cell lines, Chinese hamster ovary cells expressing mu opioid receptor alone (CHO-mu) and expressing mu opioid receptor and IRAS together (CHO-mu/IRAS), were used.
Gene_expression (expressing) of IRAS in ovary associated with mu opioid receptor
1) Confidence 0.69 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16962578 Disease Relevance 0.10 Pain Relevance 0.75
IRAS transfection into Chinese hamster ovary (CHO) or pheochromocytoma (PC-12) cell lines leads to the appearance of nonadrenergic binding sites for radiolabeled-clonidine.
Gene_expression (transfection) of IRAS in ovary associated with pheochromocytoma and clonidine
2) Confidence 0.56 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028618 Disease Relevance 0.10 Pain Relevance 0.09
Chinese hamster ovary cells co-expressing mu opioid receptor and imidazoline receptor antisera-selected protein (IRAS), the strong candidate for imidazoline I(1) receptor, were used as the cell line. cAMP overshoot, which represents an opioid dependent state in vitro, was measured to study the effects on morphine dependence. siRNA against IRAS was carried out to investigate the role of imidazoline I(1) receptor.
Gene_expression (co-expressing) of IRAS in ovary associated with addiction, mu opioid receptor, opioid and morphine
3) Confidence 0.54 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19356733 Disease Relevance 0.35 Pain Relevance 0.83
Chinese hamster ovary cells co-expressing mu opioid receptor and imidazoline receptor antisera-selected protein (IRAS), the strong candidate for imidazoline I(1) receptor, were used as the cell line. cAMP overshoot, which represents an opioid dependent state in vitro, was measured to study the effects on morphine dependence. siRNA against IRAS was carried out to investigate the role of imidazoline I(1) receptor.
Gene_expression (co-expressing) of imidazoline receptor antisera-selected protein in ovary associated with addiction, mu opioid receptor, opioid and morphine
4) Confidence 0.54 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19356733 Disease Relevance 0.35 Pain Relevance 0.83
An additional effect of agmatine at higher concentrations seems to relate to both transfected IRAS and some naive elements in CHO cells, and L-type voltage-gated calcium channels are not ruled out.
Gene_expression (transfected) of IRAS associated with calcium channel
5) Confidence 0.50 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16112088 Disease Relevance 0.23 Pain Relevance 1.12
Herein, a growth-arrested PC-12 cell line stably transfected with IRAS is shown to express lower basal and nerve growth factor-stimulated levels of the activated form of extracellular receptor kinase than found in a vector-only transfected control cell line treated similarly.
Gene_expression (transfected) of IRAS in PC-12 associated with nerve growth factor
6) Confidence 0.49 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028618 Disease Relevance 0.08 Pain Relevance 0.13
Two cell lines, Chinese hamster ovary cells expressing mu opioid receptor alone (CHO-mu) and expressing mu opioid receptor and IRAS together (CHO-mu/IRAS), were used.
Gene_expression (expressing) of IRAS in ovary associated with mu opioid receptor
7) Confidence 0.47 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16962578 Disease Relevance 0.10 Pain Relevance 0.76
In conclusion, these anti-idiotypic antibodies recognize imidazoline binding sites from human brain and allow the detection of a 43 kDa binding protein associated with or representing the imidazoline receptor expressed in human brain.
Gene_expression (expressed) of imidazoline receptor in brain
8) Confidence 0.22 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8813634 Disease Relevance 0 Pain Relevance 0.08
Therefore, IRAS, in the co-transfected CHO-mu/IRAS cell line, appears necessary for low concentrations of agmatine to cause attenuation of cellular morphine dependence.
Gene_expression (transfected) of IRAS associated with addiction and morphine
9) Confidence 0.17 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16112088 Disease Relevance 0.35 Pain Relevance 1.30
To investigate the role of imidazoline receptor antisera-selected protein (IRAS), a strong candidate for I1R, in morphine dependence, two CHO cell lines were created, in which mu opioid receptor (MOR) was stably expressed alone (CHO-mu) or MOR and IRAS were stably co-expressed (CHO-mu/IRAS).
Gene_expression (expressed) of IRAS associated with addiction, mu opioid receptor and morphine
10) Confidence 0.17 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16112088 Disease Relevance 0.35 Pain Relevance 0.96
Moxonidine is an imidazoline receptor agonist that is highly selective for the I1-imidazoline receptor with little effect at the central alpha2-receptor.
Gene_expression (selective) of I1-imidazoline receptor associated with agonist
11) Confidence 0.06 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11346219 Disease Relevance 0.20 Pain Relevance 0.05

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