INT64676

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 13.48
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANXA5) intracellular (ANXA5) cytoplasm (ANXA5)
Anatomy Link Frequency
tube 1
synovial fluid 1
cardiomyocytes 1
platelet 1
heart 1
ANXA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 3 100.00 Very High Very High Very High
Pain 17 99.76 Very High Very High Very High
imagery 19 99.48 Very High Very High Very High
rheumatoid arthritis 70 98.88 Very High Very High Very High
Angina 2 98.20 Very High Very High Very High
dexamethasone 24 97.76 Very High Very High Very High
Nicotine 86 97.72 Very High Very High Very High
Arthritis 18 85.84 High High
peptic ulcer disease 1 85.48 High High
Inflammation 27 76.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 356 99.80 Very High Very High Very High
Pain 15 99.76 Very High Very High Very High
Idiopathic Thrombocytopenic Purpura 1 99.20 Very High Very High Very High
Myocardial Infarction 8 99.12 Very High Very High Very High
Rheumatoid Arthritis 70 98.88 Very High Very High Very High
Cancer 405 98.60 Very High Very High Very High
Sickle Cell Anemia 8 98.18 Very High Very High Very High
Complex Regional Pain Syndromes 1 97.96 Very High Very High Very High
Stroke 2 97.60 Very High Very High Very High
Coronary Heart Disease 9 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of two H. pylori proteins, cytotoxin associated protein (cag A) and vacuolization cytotoxin (vac A) is considered to be related with pathogenicity of the bacterium.
Gene_expression (expression) of vac A
1) Confidence 0.75 Published 2004 Journal Srp Arh Celok Lek Section Abstract Doc Link 15938230 Disease Relevance 2.37 Pain Relevance 0.09
The annexin V concentration in patients with old myocardial infarction, chest pain syndrome, valvular heart disease, lung disease and kidney disease was 1.8 +/- 0.8, 2.0 +/- 0.7, 1.7 +/- 1.1, 2.3 +/- 1.4 and 2.1 +/- 1.2 ng/ml, respectively, being within normal limits.
Gene_expression (concentration) of annexin V in heart associated with complex regional pain syndromes, angina, pulmonary disease, renal disease, coronary heart disease and myocardial infarction
2) Confidence 0.67 Published 1996 Journal Clin. Chim. Acta Section Abstract Doc Link 8814351 Disease Relevance 1.49 Pain Relevance 0.37
During episodes of SCD pain, platelet activation was increased as compared with periods without pain (P <.01 for expression of activated integrin alpha(IIb)beta(3) receptor and P-selectin and binding of FVa and annexin V), erythrocytes expressed procoagulant activities (P <.01 for FVa and annexin V binding), and platelet microparticles appeared in the circulation (3% to 30%; P <.001).
Gene_expression (expression) of annexin V in platelet associated with sickle cell anemia and pain
3) Confidence 0.58 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11385360 Disease Relevance 0.86 Pain Relevance 0.52
Among the 15 proteins differently expressed according to the mutation status, over-expression of 5 proteins (annexin V, high mobility group protein 1, C13orf2, glutamate dehydrogenase 1, and fibrinogen beta chain) and decreased expression of RoXaN correlated with a higher tumor grade.
Gene_expression (expressed) of annexin V associated with glutamate and cancer
4) Confidence 0.12 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.46 Pain Relevance 0.05
Among the 15 proteins differently expressed according to the mutation status, over-expression of 5 proteins (annexin V, high mobility group protein 1, C13orf2, glutamate dehydrogenase 1, and fibrinogen beta chain) and decreased expression of RoXaN correlated with a higher tumor grade.
Gene_expression (expression) of annexin V associated with glutamate and cancer
5) Confidence 0.12 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.43 Pain Relevance 0.05
Among the 15 proteins differently expressed according to the mutation status, over-expression of 5 proteins (annexin V, high mobility group protein 1, C13orf2, glutamate dehydrogenase 1, and fibrinogen beta chain) and decreased expression of RoXaN correlated with a higher tumor grade.
Gene_expression (expression) of annexin V associated with glutamate and cancer
6) Confidence 0.12 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.53 Pain Relevance 0.05
Briefly, the cells to analyze with the annexin V-PI method were resuspended in 100 ?
Spec (analyze) Gene_expression (analyze) of annexin V
7) Confidence 0.11 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.84 Pain Relevance 0
T cells were identified based on scatter properties and CD3 expression and were analyzed for expression of Annexin V.


Spec (analyzed) Gene_expression (expression) of Annexin V in T cells
8) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656252 Disease Relevance 0.22 Pain Relevance 0.12
In our study, annexin V positive-PI negative cells were detected in both groups before the start of CPB, but whereas in the ModHT group the number of cardiomyocytes that had initiated the apoptotic program increased after reperfusion, in MiHT patients it remained unchanged.
Gene_expression (detected) of annexin V in cardiomyocytes associated with apoptosis
9) Confidence 0.08 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.76 Pain Relevance 0
In vitro, RA synovial fluid (SF)-derived T cells were evaluated for Annexin V expression by multicolor flow cytometry after 24-hour exposure to dexamethasone, methylprednisolone, or triamcinolone.
Gene_expression (expression) of Annexin V in synovial fluid associated with rheumatoid arthritis and dexamethasone
10) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656252 Disease Relevance 1.11 Pain Relevance 0.41
l of the sample solution was transferred to a 5 ml culture tube, and incubated with 5 ul of FITC-conjugated Annexin V and 5 ?
Gene_expression (conjugated) of Annexin V in tube
11) Confidence 0.07 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.07 Pain Relevance 0
Clearly, definitive conclusions on the influence of nicotine on apoptosis in differentiating neutrophils would require the detection of biomarkers of cell apoptosis, such as Annexin V staining, Caspase 3 activation, and DNA fragmentation.
Gene_expression (staining) of Annexin V in neutrophils associated with nicotine and apoptosis
12) Confidence 0.07 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.97 Pain Relevance 0.34
99mTc-Hynic-rh-Annexin V scintigraphy, diagnostic imaging, radiation treatment planning and image fusion
Gene_expression (scintigraphy) of Hynic-rh-Annexin V associated with imagery
13) Confidence 0.06 Published 2007 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2275773 Disease Relevance 0.36 Pain Relevance 0.11

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