INT64687

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.29
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
neuronal 2
photoreceptors 2
fibroblast 2
dorsal root ganglion 2
cortex 2
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Acupuncture 8 100.00 Very High Very High Very High
fluoxetine 6 99.04 Very High Very High Very High
dorsal root ganglion 11 98.44 Very High Very High Very High
antidepressant 1 98.16 Very High Very High Very High
Sciatic nerve 2 96.00 Very High Very High Very High
Clonidine 4 94.16 High High
depression 1 92.56 High High
Nerve growth factor 21 84.40 Quite High
cytokine 10 83.12 Quite High
Substantia nigra 2 82.32 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 13 97.96 Very High Very High Very High
Diabetes Mellitus 133 96.96 Very High Very High Very High
Parkinsonian Disorders 1 93.88 High High
Hyperglycemia 3 93.04 High High
Depression 2 92.56 High High
Injury 50 78.88 Quite High
Increased Venous Pressure Under Development 2 76.36 Quite High
Brain Injury 29 73.36 Quite High
Diabetic Neuropathy 27 70.56 Quite High
Stroke 16 62.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.
Regulation (regulation) of Gene_expression (expression) of bFGF in photoreceptors
1) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.45
Moreover, glucocorticoids might also be able to modulate FGF-2 expression in the neuronal fiber surrounding Schwann cells, which may be potentially involved in sprouting and outgrowth of lesioned axons [18].
Regulation (modulate) of Gene_expression (expression) of FGF-2 in neuronal
2) Confidence 0.62 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.23 Pain Relevance 0.22
Our data indicates that indomethacin may regulate the expression of potent angiogenic factors VEGF and FGF-2.
Spec (may) Regulation (regulate) of Gene_expression (expression) of FGF-2
3) Confidence 0.58 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17440234 Disease Relevance 0.11 Pain Relevance 0.04
We have also seen similar changes in AChE and FGF-2 expression in cortex of animals with 60 days of complex housing (Kolb et al., 1998).
Regulation (changes) of Gene_expression (expression) of FGF-2 in cortex
4) Confidence 0.39 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2991189 Disease Relevance 0.31 Pain Relevance 0.18
However, it remains unknown why MSC transplantation did not have any effects on mRNA expressions of bFGF and VEGF or NBF in normal rats.
Neg (not) Regulation (effects) of Gene_expression (expressions) of bFGF
5) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.61 Pain Relevance 0.08
Fgf2 protein and mRNA expression were not normalized by insulin treatment, with levels remaining significantly elevated compared to controls (Figure 7).
Neg (not) Regulation (normalized) of Gene_expression (expression) of Fgf2
6) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.24 Pain Relevance 0
Fluoxetine and olanzapine have synergistic effects in the modulation of fibroblast growth factor 2 expression within the rat brain.
Regulation (modulation) of Gene_expression (expression) of fibroblast growth factor 2 in fibroblast associated with fluoxetine
7) Confidence 0.27 Published 2004 Journal Biol. Psychiatry Section Title Doc Link 15158429 Disease Relevance 0.09 Pain Relevance 0.29
Effects of acupuncture on the expression of glial cell line-derived neurotrophic factor (GDNF) and basic fibroblast growth factor (FGF-2/bFGF) in the left sixth lumbar dorsal root ganglion following removal of adjacent dorsal root ganglia.
Regulation (Effects) of Gene_expression (expression) of basic fibroblast growth factor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and acupuncture
8) Confidence 0.07 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15925097 Disease Relevance 0.72 Pain Relevance 0.63

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