INT64688

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 5.07
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
endothelial cells 3
spinal cord segment 2
pituitary 2
brain structures 2
fibroblasts 1
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 99.64 Very High Very High Very High
allodynia 3 99.48 Very High Very High Very High
Spinal cord 4 98.72 Very High Very High Very High
antagonist 1 97.40 Very High Very High Very High
Arthritis 124 94.84 High High
chemokine 4 94.56 High High
Clonidine 4 93.68 High High
COX-2 inhibitor 4 93.44 High High
agonist 40 90.96 High High
Spinal nerve ligature 1 88.88 High High
Disease Link Frequency Relevance Heat
Cancer 4 100.00 Very High Very High Very High
Pituitary Cancer 2 100.00 Very High Very High Very High
Neuropathic Pain 9 99.48 Very High Very High Very High
Ulcers 8 98.96 Very High Very High Very High
Pituitary Apoplexy 4 98.28 Very High Very High Very High
Arthritis 254 94.84 High High
Stroke 2 81.68 Quite High
Pain 4 80.96 Quite High
Nervous System Injury 1 76.76 Quite High
Peptic Ulcer 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher dosage of yohimbine inhibited the baseline expression of bFGF.
Negative_regulation (inhibited) of Gene_expression (expression) of bFGF
1) Confidence 0.59 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.48
Administration of 18 microg of anti-FGF-2 antibodies attenuated mechanical allodynia at day 21 after SpNL and reduced FGF-2 and glial acidic fibrillary protein mRNA expression and immunoreactivity in the L5 spinal cord segment of rats with SpNL.
Negative_regulation (reduced) of Gene_expression (expression) of FGF-2 in spinal cord segment associated with allodynia and spinal cord
2) Confidence 0.59 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 16280602 Disease Relevance 0.84 Pain Relevance 0.89
It decreased the number of microvessels, bFGF protein expression, and PGE(2) level in the ulcer base at day 6.
Negative_regulation (decreased) of Gene_expression (expression) of bFGF associated with ulcers
3) Confidence 0.53 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12217640 Disease Relevance 1.02 Pain Relevance 0.22
Ribonuclease (RNase) protection assay and Western blot analysis were employed to determine FGF-2 expression in different brain structures and to identify the intracellular pathways possibly involved in FGF-2 modulation.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of FGF-2 in brain structures
4) Confidence 0.42 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15158429 Disease Relevance 0 Pain Relevance 0
We showed further that TZDs decreased the expression of bFGF, which is a powerful mitogen for both synovial fibroblasts and endothelial cells whose neutralization was reported to attenuate arthritis severity [51].
Negative_regulation (decreased) of Gene_expression (expression) of bFGF in endothelial cells associated with arthritis
5) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.10 Pain Relevance 0.40
We showed further that TZDs decreased the expression of bFGF, which is a powerful mitogen for both synovial fibroblasts and endothelial cells whose neutralization was reported to attenuate arthritis severity [51].
Negative_regulation (decreased) of in fibroblasts Gene_expression (expression) of bFGF in endothelial cells associated with arthritis
6) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.10 Pain Relevance 0.40
Immunohistochemical analysis was used to define the different hormone types of the tumors and the expression of various immunologic targets, including the pituitary tumor transforming gene, basic fibroblast growth factor-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and proliferating cell nuclear antigen.
Negative_regulation (define) of Gene_expression (expression) of basic fibroblast growth factor-2 in pituitary associated with cancer, pituitary cancer and metalloproteinase
7) Confidence 0.08 Published 2009 Journal J Clin Neurosci Section Abstract Doc Link 19046883 Disease Relevance 1.01 Pain Relevance 0.17

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