INT64689

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 30
Total Number 34
Disease Relevance 12.05
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
fibroblast 16
neuronal 4
photoreceptors 4
lateral 4
astrocytes 4
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 96 99.98 Very High Very High Very High
antidepressant 55 99.76 Very High Very High Very High
fluoxetine 29 99.62 Very High Very High Very High
Central nervous system 45 99.52 Very High Very High Very High
Pain 18 99.46 Very High Very High Very High
cytokine 102 98.94 Very High Very High Very High
dexamethasone 3 98.84 Very High Very High Very High
Inflammation 150 98.74 Very High Very High Very High
Substantia nigra 6 96.52 Very High Very High Very High
Sciatic nerve 18 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 40 100.00 Very High Very High Very High
Hyperplasia 24 99.90 Very High Very High Very High
Retinal Degeneration 116 99.80 Very High Very High Very High
Hydrocephalus 36 99.80 Very High Very High Very High
Pain 12 99.46 Very High Very High Very High
Pituitary Cancer 44 99.44 Very High Very High Very High
Arthritis 10 99.34 Very High Very High Very High
INFLAMMATION 161 98.74 Very High Very High Very High
Prolactinoma 8 97.80 Very High Very High Very High
Injury 245 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors.
Positive_regulation (induced) of Gene_expression (expression) of bFGF in photoreceptors
1) Confidence 0.70 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.48
Moreover, dexamethasone, a potent synthetic glucocorticoid agonist, was shown to induce the FGF-2 gene expression in primary culture of rat astrocytes from different CNS regions [86], and also to increase FGF-2 immunoreactivity in the substantia nigra astrocytes [88], further emphasizing the influence of steroid hormones on astroglial FGF-2 mechanisms.
Positive_regulation (induce) of Gene_expression (expression) of FGF-2 in substantia nigra associated with substantia nigra, agonist, central nervous system and dexamethasone
2) Confidence 0.70 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.26 Pain Relevance 0.24
Antidepressant treatments induce the expression of basic fibroblast growth factor in cortical and hippocampal neurons.
Positive_regulation (induce) of Gene_expression (expression) of basic fibroblast growth factor in neurons associated with antidepressant
3) Confidence 0.70 Published 2002 Journal Mol. Pharmacol. Section Title Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.54
The data indicate that spinal astrocytes may influence pain processes particularly by increased FGF-2 synthesis.
Positive_regulation (increased) of Gene_expression (synthesis) of FGF-2 in spinal associated with pain
4) Confidence 0.69 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135927 Disease Relevance 0.43 Pain Relevance 0.18
In OLETF rat hearts, significant increases in vascular expressions for VEGF, bFGF and TGF- beta(1) were found.
Positive_regulation (increases) of Gene_expression (expressions) of bFGF in hearts
5) Confidence 0.63 Published 2002 Journal Diabetologia Section Body Doc Link 11914746 Disease Relevance 0.07 Pain Relevance 0
In the present study, nilvadipine-induced enhancement of the endogenous FGF-2 and Arc expressions were also recognized in P23H model.
Positive_regulation (induced) of Gene_expression (expressions) of FGF-2 associated with aids-related complex
6) Confidence 0.61 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.65 Pain Relevance 0.04
Thus, we suggested that systemic administration of nilvadipine to RCS rats increases the expression of endogenous FGF-2 and Arc in retina, and potentially have a protective effect against retinal degeneration.
Positive_regulation (increases) of Gene_expression (expression) of FGF-2 in retina associated with retinal degeneration and aids-related complex
7) Confidence 0.61 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.60 Pain Relevance 0.07
In an independent experiment, insulin replacement therapy normalized the expression of some proteins (Dbi, Anxa5) while other proteins (Cp, Cryba3, Lgals3, Stat3) were only partially normalized and Fgf2 and Crybb2 expression remained elevated.


Positive_regulation (elevated) of Gene_expression (expression) of Fgf2
8) Confidence 0.56 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020973 Disease Relevance 0.41 Pain Relevance 0.04
Because the levels of astroglial reaction (seen by the increased number of GFAP immunepositive cells) and the levels of the changes in the astroglial FGF-2 immunoreactivity were higher after facial nerve transection (without fiber regeneration) than after crush (leading to a favorable regeneration), it is possible that such a regenerative failure-impairing the internalization of FGF-2 synthesized in the periphery might have favored FGF-2 synthesis in reactive astrocytes of transected facial nucleus.
Positive_regulation (favored) of Gene_expression (synthesis) of FGF-2 in astrocytes
9) Confidence 0.50 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0 Pain Relevance 0.08
The present study is aimed at establishing whether prolonged antidepressant treatments increase the expression of basic fibroblast growth factor (FGF2), a polypeptide growth factor that has a broad neurotrophic activity in the adult central nervous system.
Spec (whether) Positive_regulation (increase) of Gene_expression (expression) of basic fibroblast growth factor in fibroblast associated with antidepressant and central nervous system
10) Confidence 0.50 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.47
The present study is aimed at establishing whether prolonged antidepressant treatments increase the expression of basic fibroblast growth factor (FGF2), a polypeptide growth factor that has a broad neurotrophic activity in the adult central nervous system.
Spec (whether) Positive_regulation (increase) of Gene_expression (expression) of FGF2 in fibroblast associated with antidepressant and central nervous system
11) Confidence 0.50 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.47
Otherwise the presence or absence of TRPC5 and TRPC6 in association with TRPC1 may help to explain bFGF-activated current changes during the neuronal differentiation from A2B5+ NPCs possibly via formation of different heteromeric TRPC complexes such as heteromeric TRPC (1+5) and TRPC (1+3+5) channels as described previously [10].
Spec (possibly) Positive_regulation (activated) of Gene_expression (explain) of bFGF in neuronal associated with trp channel
12) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.20 Pain Relevance 0.32
Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage.
Positive_regulation (induce) of Gene_expression (expression) of basic fibroblast growth factor in photoreceptors associated with agonist
13) Confidence 0.47 Published 1996 Journal J. Neurosci. Section Title Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.46
Lesions to the CNS have been described to induce a strong expression of FGF-2 mRNA and protein in activated astroglial cells in the area of the injury [11-14].
Positive_regulation (induce) of Gene_expression (expression) of FGF-2 mRNA associated with injury and central nervous system
14) Confidence 0.47 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.21 Pain Relevance 0.22
Following inflammation, the area density of GFAP-IR as well as the proportion of astrocytes expressing FGF-2 increased significantly while the degree of astrocyte arborisation decreased as shown by a shape factor.
Positive_regulation (increased) of Gene_expression (expressing) of FGF-2 in astrocytes associated with inflammation
15) Confidence 0.47 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135927 Disease Relevance 0.35 Pain Relevance 0.18
We have found increased acetylcholinesterase (AChE) levels in cortex and increased expression of at least one neurotrophic factor, fibroblast growth factor-2 (FGF-2), in both skin and brain (R.
Positive_regulation (increased) of Gene_expression (expression) of FGF-2 in fibroblast
16) Confidence 0.44 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2991189 Disease Relevance 0.48 Pain Relevance 0.20
We have found increased acetylcholinesterase (AChE) levels in cortex and increased expression of at least one neurotrophic factor, fibroblast growth factor-2 (FGF-2), in both skin and brain (R.
Positive_regulation (increased) of Gene_expression (expression) of fibroblast growth factor-2 in fibroblast
17) Confidence 0.44 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2991189 Disease Relevance 0.48 Pain Relevance 0.20
We have found increased acetylcholinesterase (AChE) levels in cortex and increased expression of at least one neurotrophic factor, fibroblast growth factor-2 (FGF-2), in both skin and brain (R.
Positive_regulation (increased) of Gene_expression (expression) of fibroblast growth factor-2 in fibroblast
18) Confidence 0.44 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2991189 Disease Relevance 0.41 Pain Relevance 0.19
We have found increased acetylcholinesterase (AChE) levels in cortex and increased expression of at least one neurotrophic factor, fibroblast growth factor-2 (FGF-2), in both skin and brain (R.
Positive_regulation (increased) of Gene_expression (expression) of FGF-2 in fibroblast
19) Confidence 0.44 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2991189 Disease Relevance 0.42 Pain Relevance 0.19
To estimate the nilvadipine-dependent preservation effects against P23H retinal degenerations, retinal expressions of FGF2 and Arc, which were significantly enhanced in nilvadipine-treated RCS rat as compared to the control (Sato et al 2003), were immunohistochemically investigated.
Positive_regulation (enhanced) of Gene_expression (expressions) of FGF2 associated with retinal degeneration and aids-related complex
20) Confidence 0.41 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.35 Pain Relevance 0

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