INT64690

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Context Info
Confidence 0.09
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
projection neurons 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
projection neuron 1 96.24 Very High Very High Very High
substance P 5 89.32 High High
Action potential 11 89.04 High High
Enkephalin 5 89.04 High High
Dopamine 107 86.04 High High
Glutamate 14 82.36 Quite High
dopamine receptor 6 75.00 Quite High
antagonist 11 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
tetrodotoxin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dopaminergic suppression of synaptic transmission is therefore mediated by a D2 receptor-dependent reduction in transmitter release, and a D1 receptor-dependent increase in a K+ conductance.
Negative_regulation (reduction) of Localization (release) of D1 receptor
1) Confidence 0.09 Published 2008 Journal Neural Plasticity Section Abstract Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.23
These results suggest that, although colocalization of D1a and D2 receptors is limited, functional D1 and D2 class receptors are colocalized in nearly one-half of all medium spiny projection neurons.
Negative_regulation (limited) of Localization (colocalization) of D1a in projection neurons associated with projection neuron
2) Confidence 0.08 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815934 Disease Relevance 0 Pain Relevance 0.73

General Comments

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