INT647

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Context Info
Confidence 0.75
First Reported 1977
Last Reported 2010
Negated 8
Speculated 5
Reported most in Abstract
Documents 211
Total Number 216
Disease Relevance 78.46
Pain Relevance 55.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
oocytes 13
chondrocytes 5
embryonic kidney 4
brain 4
tendon 3
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 43 100.00 Very High Very High Very High
gABA 42 100.00 Very High Very High Very High
Morphine 36 100.00 Very High Very High Very High
Opioid 30 100.00 Very High Very High Very High
opioid receptor 27 100.00 Very High Very High Very High
antagonist 26 100.00 Very High Very High Very High
qutenza 25 100.00 Very High Very High Very High
opiate 17 100.00 Very High Very High Very High
Serotonin 16 100.00 Very High Very High Very High
Sumatriptan 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 656 100.00 Very High Very High Very High
Apoptosis 40 100.00 Very High Very High Very High
Nociception 8 100.00 Very High Very High Very High
Cold Sores 7 100.00 Very High Very High Very High
Dentatorubro-pallidoluysian Atrophy 1 100.00 Very High Very High Very High
Cancer 873 99.96 Very High Very High Very High
Targeted Disruption 9 99.88 Very High Very High Very High
Disease 207 99.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 34 99.84 Very High Very High Very High
Adhesions 31 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The endothelial cells but not the paraventricular hypothalamic cells displayed a concomitant induction of cyclooxygenase-2 and expressed interleukin-1 type 1 receptors, which indicates that the induction is due to peripherally released cytokines.
Gene_expression (expressed) of type in endothelial cells associated with cytokine
1) Confidence 0.75 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 12353217 Disease Relevance 0.60 Pain Relevance 0.27
Stable or transient expression of wild-type MC1R, but not of loss-of-function mutants, potently stimulates forskolin activation of adenylyl cyclase, a common feature of constitutively active Gs-coupled receptors.
Gene_expression (expression) of type associated with melanocortin 1 receptor
2) Confidence 0.75 Published 2004 Journal Pigment Cell Res. Section Abstract Doc Link 15250941 Disease Relevance 0.29 Pain Relevance 1.15
METHODS: Heteromeric human neuronal nicotinic acetylcholine receptors (hnAChR channels alpha2beta2, alpha2beta4, alpha3beta2, alpha3beta4, alpha4beta2 and alpha4beta4), 5-hydroxytryptamine3 (5-HT3), alpha1beta2gamma2S gamma-aminobutyric acid type A (GABAA) and alpha1 glycine receptors were expressed in Xenopus oocytes, and effects of ketamine and dizocilpine were studied using the two-electrode voltage-clamp technique.
Gene_expression (expressed) of type in oocytes
3) Confidence 0.75 Published 2000 Journal Anesthesiology Section Body Doc Link 10754635 Disease Relevance 0 Pain Relevance 0
An immunoserological investigation showed expression of IgM-kappa type monoclonal cryoglobulin.
Gene_expression (expression) of type
4) Confidence 0.75 Published 2004 Journal Pathol. Int. Section Abstract Doc Link 15363040 Disease Relevance 1.04 Pain Relevance 0.10
PPARgamma and vanilloid receptor type 1 (VR-1) expressions at the protein or mRNA levels were detected by western blot analysis and reverse transcription-polymerase chain reaction.
Gene_expression (expressions) of type
5) Confidence 0.75 Published 2004 Journal J Med Food Section Abstract Doc Link 15383218 Disease Relevance 1.35 Pain Relevance 0.52
This study provides molecular evidence that mu-type opiate receptors are expressed in molluscan ganglia, suggesting that they first appear in invertebrate organisms and are retained during evolution.
Gene_expression (expressed) of type in ganglia associated with opiate
6) Confidence 0.75 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10640698 Disease Relevance 0 Pain Relevance 0.50
Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc.
Gene_expression (expression) of type in epithelial cells associated with apoptosis
7) Confidence 0.75 Published 1999 Journal Biochem. Pharmacol. Section Title Doc Link 10403534 Disease Relevance 0.90 Pain Relevance 0.20
Serum type I collagen C-telopeptide (sCTX), urinary free-deoxypyridinoline (ufDPD), bone alkaline phosphatase (ALP) and serum osteocalcin levels were determined.
Gene_expression (levels) of type
8) Confidence 0.75 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 15952402 Disease Relevance 0.51 Pain Relevance 0.06
Another abnormality in endometriosis, the deficient 17beta-hydroxysteroiddehydrogenase type II (17beta-HSD-Type-II) expression, impairs the inactivation of estradiol to estrone.
Gene_expression (expression) of type associated with endometriosis
9) Confidence 0.75 Published 2005 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 16157442 Disease Relevance 0.69 Pain Relevance 0.29
The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes.
Gene_expression (expressed) of type in Oocytes associated with tramadol
10) Confidence 0.75 Published 2006 Journal Pharmacology Section Title Doc Link 16679816 Disease Relevance 0.08 Pain Relevance 1.10
5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals.
Gene_expression (coexpressing) of type
11) Confidence 0.75 Published 2006 Journal Pharmacogenet. Genomics Section Title Doc Link 16847428 Disease Relevance 0 Pain Relevance 0.21
Gabapentin and pregabalin slow the rate of inactivation in recombinant P/Q-type VDCCs, expressed in Xenopus oocytes.
Gene_expression (expressed) of type in oocytes associated with pregabalin and gabapentin
12) Confidence 0.75 Published 2007 Journal Med. Hypotheses Section Abstract Doc Link 16899342 Disease Relevance 1.06 Pain Relevance 0.91
However, there are minimal data detailing expression of ectonucleotidases and type-2 purinergic receptors (P2R) in chronic pancreatitis and pancreatic cancer.
Gene_expression (expression) of type associated with pancreatic cancer and chronic pancreatitis
13) Confidence 0.75 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.20 Pain Relevance 0.41
Expression, purification and transduction of PEP-1-botulinum neurotoxin type A (PEP-1-BoNT/A) into skin.
Gene_expression (Expression) of type in skin
14) Confidence 0.75 Published 2006 Journal J. Biochem. Mol. Biol. Section Title Doc Link 17002886 Disease Relevance 0.19 Pain Relevance 0.18
The wild-type mu receptor and the D114N mutant were then stably expressed in human embryonic kidney 293 cells, and the binding affinities of a series of opioids were investigated.
Gene_expression (expressed) of type in embryonic kidney associated with opioid
15) Confidence 0.75 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9422382 Disease Relevance 0 Pain Relevance 0.75
Heterotopic ossification derived cells were shown to produce osteocalcin, Type 1 collagen, and alkaline phosphatase activity.
Gene_expression (produce) of Type associated with heterotopic ossification
16) Confidence 0.75 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.58 Pain Relevance 0.07
Taken together, these studies provide molecular evidence that mu-type opiate receptors are expressed in human vascular endothelia and that their expression can be upregulated by proinflammatory cytokines.
Gene_expression (expressed) of type in vascular endothelia associated with opiate and cytokine
17) Confidence 0.75 Published 2000 Journal Endothelium Section Abstract Doc Link 10912912 Disease Relevance 0 Pain Relevance 0.58
METHODS: The glycine, GABAA, GABA receptor type C (GABAC), NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate, 5-hydroxytryptamine3 (5-HT3), and nicotinic acetylcholine (nACh) receptors were expressed in Xenopus oocytes and effects of nitrous oxide and xenon, and as equipotent concentrations of isoflurane and ethanol, were studied using the two-electrode voltage clamp.
Gene_expression (expressed) of type in oocytes
18) Confidence 0.75 Published 2000 Journal Anesthesiology Section Body Doc Link 11020766 Disease Relevance 0 Pain Relevance 0
In breast carcinoma an increase in expression of peripheral-type benzodiazepine receptors (PBR) and the gamma aminobutyl acid (GABA) level has been discovered.
Gene_expression (expression) of type associated with gaba
19) Confidence 0.75 Published 2002 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 12139540 Disease Relevance 0.27 Pain Relevance 0.43
A randomized, double-masked, crossover comparison of the efficacy and safety of botulinum toxin type A produced from the original bulk toxin source and current bulk toxin source for the treatment of cervical dystonia.
Gene_expression (produced) of type associated with pain, torticollis and botox
20) Confidence 0.75 Published 2002 Journal J. Neurol. Section Title Doc Link 11954869 Disease Relevance 0.36 Pain Relevance 0.41

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