INT64711

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 3.12
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
cholinergic neurons 2
urinary bladder 1
brain 1
neuronal 1
neurons 1
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 5 100.00 Very High Very High Very High
Glutamate receptor 1 100.00 Very High Very High Very High
cerebral cortex 2 99.80 Very High Very High Very High
Thalamus 2 99.56 Very High Very High Very High
Acupuncture 82 99.16 Very High Very High Very High
Calcitonin gene-related peptide 5 98.68 Very High Very High Very High
Nerve growth factor 110 97.52 Very High Very High Very High
Inflammation 5 96.96 Very High Very High Very High
gABA 1 96.72 Very High Very High Very High
Root ganglion neuron 2 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Down Syndrome 2 98.68 Very High Very High Very High
Disease 15 97.96 Very High Very High Very High
Obesity 2 97.88 Very High Very High Very High
INFLAMMATION 7 96.96 Very High Very High Very High
Apoptosis 25 96.48 Very High Very High Very High
Metabolic Syndrome 3 95.88 Very High Very High Very High
Ganglion Cysts 11 95.64 Very High Very High Very High
Pain 7 95.28 Very High Very High Very High
Inflammatory Pain 5 91.48 High High
Polycystic Ovary Syndrome 87 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of the current study was to investigate the effect of p75NTR saporin, a toxin used to destroy p75NTR, on calcitonin gene-related peptide (CGRP), an inflammatory neuropeptide associated with pain, in DRG neurons innervating punctured intervertebral discs in rats.
Spec (investigate) Regulation (effect) of p75NTR in neurons associated with dorsal root ganglion, pain, inflammation, neuropeptide and calcitonin gene-related peptide
1) Confidence 0.45 Published 2010 Journal J Orthop Sci Section Abstract Doc Link 20559810 Disease Relevance 0.64 Pain Relevance 0.59
Effect of applying p75NTR saporin to a punctured intervertebral disc on calcitonin gene-related peptide expression in rat dorsal root ganglion neurons.
Regulation (applying) of p75NTR in dorsal root ganglion associated with ganglion cysts, root ganglion neuron and calcitonin gene-related peptide
2) Confidence 0.45 Published 2010 Journal J Orthop Sci Section Title Doc Link 20559810 Disease Relevance 0.36 Pain Relevance 0.55
Furthermore, EA was able to counteract the EV-induced up regulation of p75NTR, probably by normalizing the sympathetic ovarian response to NGF action.
Regulation (regulation) of p75NTR in sympathetic associated with nerve growth factor and acupuncture
3) Confidence 0.40 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1175857 Disease Relevance 0.40 Pain Relevance 0.37
Expression profile of ChAT and p75 immunopositive septal cholinergic neurons after axotomy of the fimbria-fornix: a time course study
Regulation (immunopositive) of p75 in cholinergic neurons
4) Confidence 0.33 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.31 Pain Relevance 0.21
Expression profile of ChAT and p75 immunopositive septal cholinergic neurons after axotomy of the fimbria-fornix: a time course study
Regulation (profile) of p75 in cholinergic neurons
5) Confidence 0.33 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.32 Pain Relevance 0.21
CGRP and p75NTR immunoreactivity was upregulated in the CFA + saline groups compared with a control group (p<.01).
Regulation (immunoreactivity) of p75NTR
6) Confidence 0.27 Published 2010 Journal J Hand Surg Am Section Body Doc Link 20060234 Disease Relevance 0.06 Pain Relevance 0
When P7 rats (at the peak of brain development) were exposed to a commonly-used and highly pro-apoptotic anesthesia protocol (midazolam, isoflurane, nitrous oxide) for a period of 2, 4 or 6 h, we found that anesthesia modulates the key steps in BDNF-activated apoptotic cascade in two of the most vulnerable brain regions--cerebral cortex and thalamus in time-dependent fashion by activating both Trk-dependent (in thalamus) and Trk-independent p75NTR dependent (in cerebral cortex) neurotrophic pathways. beta-estradiol, a sex hormone that upregulates the protein levels of the activated Akt, protects against anesthesia-induced neuroapoptosis.
Neg (independent) Regulation (dependent) of p75NTR in brain associated with anesthesia, versed, thalamus, isoflurane, apoptosis and cerebral cortex
7) Confidence 0.26 Published 2006 Journal Apoptosis Section Abstract Doc Link 16738805 Disease Relevance 0.34 Pain Relevance 0.69
Electron microscopy revealed that p75 immunoreactivity was localized on the surface of Schwann cells and at the sites where they were apposed to axons.
Regulation (immunoreactivity) of p75 in Schwann cells
8) Confidence 0.26 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817519 Disease Relevance 0.33 Pain Relevance 0.36
Up-regulated include NMDA-R2D, neuropeptide Y (NPY), proenkephalin, BDNF and NGFR.
Regulation (regulated) of NGFR associated with neuropeptide
9) Confidence 0.10 Published 2003 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 14983999 Disease Relevance 0 Pain Relevance 0.70
Alterations of nerve-growth factor and p75(NTR) expressions in urinary bladder of fructose-fed obese rats.
Regulation (Alterations) of p75 in urinary bladder associated with obesity
10) Confidence 0.10 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18585860 Disease Relevance 0.35 Pain Relevance 0.08
It is of interest to note that p75 was observed to be regulated in an activity-dependent manner in a study using neuronal cultures [25].
Regulation (regulated) of p75 in neuronal
11) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0 Pain Relevance 0
Analysis of postsynaptic densities (PSDs) by immunoblotting revealed no changes in the glutamate receptor subunits GluR1, NR1, NR2A/B, mGluR1alpha nor in the neurotrophin receptor p75(NTR).
Neg (no) Regulation (changes) of neurotrophin receptor p75 associated with glutamate receptor
12) Confidence 0.03 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.57

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