INT64713

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2008
Negated 1
Speculated 4
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 2.04
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
dorsal root ganglia 4
nerve 2
keratinocytes 2
motoneurons 2
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 12 100.00 Very High Very High Very High
IPN 2 99.04 Very High Very High Very High
Nerve growth factor 19 95.64 Very High Very High Very High
Sciatic nerve 1 90.92 High High
Thermal hyperalgesia 1 82.04 Quite High
anesthesia 1 81.36 Quite High
Pain 1 74.16 Quite High
Neuronal nitric oxide synthase 1 60.24 Quite High
Hyperalgesia 2 51.68 Quite High
Sciatica 3 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Metabolic Syndrome 2 100.00 Very High Very High Very High
Obesity 2 99.32 Very High Very High Very High
Inflammatory Pain 2 99.04 Very High Very High Very High
Cystitis 2 98.16 Very High Very High Very High
Death 2 91.08 High High
Injury 2 84.72 Quite High
Hyperalgesia 3 82.04 Quite High
Neuropathic Pain 2 79.44 Quite High
Pain 1 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study investigated the effects of metabolic syndrome on urinary bladder nerve-growth factor (NGF) and p75(NTR) expression in fructose-fed obese rats.
Spec (investigated) Regulation (effects) of Spec (investigated) Gene_expression (expression) of p75 in nerve associated with obesity and metabolic syndrome
1) Confidence 0.50 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18585860 Disease Relevance 0.33 Pain Relevance 0.08
Here, we examined the effect of inflammation on expression of the low affinity neurotrophin receptor p75, using the model of cyclophosphamide-induced cystitis in rats.
Spec (examined) Regulation (effect) of Gene_expression (expression) of neurotrophin receptor associated with inflammation and cystitis
2) Confidence 0.38 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817519 Disease Relevance 0.37 Pain Relevance 0.32
The effects of this delivery over 12 days were then determined on expression of growth-associated protein-43, trkA, p75NTR and preprotachykinin A ipsilateral and contralateral to the pump in dorsal root ganglia at L4 and L5 (pooled).
Regulation (effects) of Spec (determined) Gene_expression (expression) of p75NTR in dorsal root ganglia
3) Confidence 0.35 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336076 Disease Relevance 0 Pain Relevance 0.21
The CB1093 did not affect expression of nerve growth factor receptors (trkA and p75(NTR)) in dorsal root ganglia in control or diabetic rats, though the p75(NTR) expression was reduced by diabetes.
Neg (not) Regulation (affect) of Gene_expression (expression) of p75 in dorsal root ganglia
4) Confidence 0.29 Published 1999 Journal Diabetologia Section Body Doc Link 10550414 Disease Relevance 0 Pain Relevance 0
Here, we examined the effect of inflammation on expression of the low affinity neurotrophin receptor p75, using the model of cyclophosphamide-induced cystitis in rats.
Spec (examined) Regulation (effect) of Gene_expression (expression) of p75 associated with inflammation and cystitis
5) Confidence 0.26 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817519 Disease Relevance 0.37 Pain Relevance 0.32
NGF and p75 expression (mRNA and protein) increases in the skin (keratinocytes) in the acute phase of CFA inflammation; 3). at this stage, a higher proliferative activity is observed in the skin, as defined by the expression of cell cycle-associated protein Ki67; 4). in the long-lasting chronic phase there is a further up-regulation of NFG and p75 expression in the skin; 5). trkA mRNA expression inversely correlates with p75 and NGF mRNA expression.
Regulation (regulation) of Gene_expression (expression) of p75 in keratinocytes associated with inflammation
6) Confidence 0.26 Published 2008 Journal Histol. Histopathol. Section Abstract Doc Link 17952852 Disease Relevance 0.65 Pain Relevance 0.40
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Regulation (regulation) of Gene_expression (expression) of P75 in motoneurons
7) Confidence 0.21 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03

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