INT64714

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.22
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
spinal cord 3
DRG 1
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 10 99.98 Very High Very High Very High
narcan 3 99.36 Very High Very High Very High
antagonist 2 99.18 Very High Very High Very High
opiate 4 98.96 Very High Very High Very High
Spinal cord 14 98.76 Very High Very High Very High
intrathecal 2 98.32 Very High Very High Very High
Sciatic nerve 2 96.12 Very High Very High Very High
Morphine 2 93.08 High High
Inflammation 2 83.92 Quite High
cytokine 3 83.88 Quite High
Disease Link Frequency Relevance Heat
Injury 10 99.98 Very High Very High Very High
Acute-phase Reaction 1 85.96 High High
INFLAMMATION 2 83.52 Quite High
Necrosis 6 83.32 Quite High
Cancer 6 82.96 Quite High
Obesity 39 82.00 Quite High
Neuropathic Pain 6 78.92 Quite High
Nervous System Injury 2 77.72 Quite High
Appetite Loss 14 72.20 Quite High
Body Weight 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When injected intraperitoneally, the opiate antagonist naloxone hydrochloride, antagonized the IL-6 response induced by either i.c.v. or i.p.
Positive_regulation (induced) of Phosphorylation (response) of IL-6 associated with antagonist, narcan and opiate
1) Confidence 0.50 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817528 Disease Relevance 0.17 Pain Relevance 0.92
We also observed that the increased phosphorylations of p70S6K and 4EBP1, induced by exercise, were also reversed by antiĀ–IL-6 infusion (Figures 6e and f).
Positive_regulation (increased) of Phosphorylation (phosphorylations) of IL-6
2) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.56 Pain Relevance 0
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of IL-6 mRNA in spinal cord associated with eae, spinal cord and intrathecal
3) Confidence 0.34 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.25 Pain Relevance 0.88
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Positive_regulation (elevated) of in DRG Phosphorylation (phosphorylation) of IL-6 mRNA in spinal cord associated with eae, spinal cord and intrathecal
4) Confidence 0.11 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.25 Pain Relevance 0.88

General Comments

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