INT64715

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Context Info
Confidence 0.81
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.24
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
hypothalamus 1
spinal cord 1
DRG 1
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 3 99.36 Very High Very High Very High
antagonist 2 99.18 Very High Very High Very High
opiate 4 98.96 Very High Very High Very High
Spinal cord 19 98.76 Very High Very High Very High
Eae 16 98.36 Very High Very High Very High
Sciatic nerve 3 98.08 Very High Very High Very High
intrathecal 2 96.70 Very High Very High Very High
Morphine 2 93.08 High High
Pain 6 91.20 High High
Neuropathic pain 9 84.44 Quite High
Disease Link Frequency Relevance Heat
Injury 16 98.36 Very High Very High Very High
Pain 2 91.20 High High
Obesity 79 89.40 High High
Acute-phase Reaction 1 85.96 High High
Neuropathic Pain 10 84.44 Quite High
INFLAMMATION 18 83.52 Quite High
Nervous System Injury 6 83.32 Quite High
Necrosis 8 80.08 Quite High
Cancer 9 79.72 Quite High
Appetite Loss 28 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When injected intraperitoneally, the opiate antagonist naloxone hydrochloride, antagonized the IL-6 response induced by either i.c.v. or i.p.
Phosphorylation (response) of IL-6 associated with antagonist, narcan and opiate
1) Confidence 0.81 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817528 Disease Relevance 0.17 Pain Relevance 0.91
B (p65) (1:1,000), phosphorylated NF-IL-6 (1:1,500), or phosphorylated AP-1 (c-Jun) (1:500).
Phosphorylation (phosphorylated) of IL-6
2) Confidence 0.68 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0
We also observed that the increased phosphorylations of p70S6K and 4EBP1, induced by exercise, were also reversed by antiĀ–IL-6 infusion (Figures 6e and f).
Phosphorylation (phosphorylations) of IL-6
3) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.56 Pain Relevance 0
Similar temporal changes in the expression of IL-6, phosphorylated p38 MAPK and CX3CR1 were observed following CCI.
Phosphorylation (phosphorylated) of IL-6 associated with eae
4) Confidence 0.58 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 0.91 Pain Relevance 0.72
As well as in response to leptin, in the present study, we demonstrated that IL-6 alone reduced AMPK phosphorylation in the hypothalamus of rats.
Phosphorylation (phosphorylation) of IL-6 in hypothalamus
5) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.16 Pain Relevance 0
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Phosphorylation (phosphorylation) of IL-6 mRNA in spinal cord associated with eae, spinal cord and intrathecal
6) Confidence 0.45 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.22 Pain Relevance 0.86
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Phosphorylation (phosphorylation) of IL-6 mRNA in DRG associated with eae, spinal cord and intrathecal
7) Confidence 0.15 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.22 Pain Relevance 0.86

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