INT64716

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 2.83
Pain Relevance 5.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
nerves 2
spinal cord 2
spinal cord dorsal horn 2
PGE2 2
plasma 1
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 100.00 Very High Very High Very High
antagonist 10 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Spinal cord 4 100.00 Very High Very High Very High
Peripheral nerve injury 3 100.00 Very High Very High Very High
Dorsal horn 3 100.00 Very High Very High Very High
tramadol 2 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Inflammation 26 99.76 Very High Very High Very High
Calcitonin gene-related peptide 14 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 100.00 Very High Very High Very High
INFLAMMATION 34 99.76 Very High Very High Very High
Neuropathic Pain 9 99.52 Very High Very High Very High
Obesity 40 98.72 Very High Very High Very High
Acute-phase Reaction 3 97.64 Very High Very High Very High
Carcinoma 1 90.20 High High
Inflammatory Pain 1 89.88 High High
Hyperalgesia 2 85.84 High High
Pain 2 85.80 High High
Neuroma 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of opiate agonists and antagonists on the induction of serum interleukin-6 (IL-6), an inflammatory cytokine that plays a major role in the acute phase response, was studied.
Regulation (effect) of Positive_regulation (induction) of serum interleukin-6 associated with acute-phase reaction, inflammation, antagonist, agonist, opiate and cytokine
1) Confidence 0.54 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817528 Disease Relevance 0.20 Pain Relevance 0.76
The effect of opiate agonists and antagonists on the induction of serum interleukin-6 (IL-6), an inflammatory cytokine that plays a major role in the acute phase response, was studied.
Regulation (effect) of Positive_regulation (induction) of IL-6 associated with acute-phase reaction, inflammation, antagonist, agonist, opiate and cytokine
2) Confidence 0.45 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817528 Disease Relevance 0.20 Pain Relevance 0.77
This study was undertaken to determine whether PGE2 is involved in the up-regulation of IL-6 in invading macrophages.
Spec (whether) Regulation (involved) of Spec (whether) Positive_regulation (up-regulation) of IL-6 in PGE2
3) Confidence 0.40 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15836625 Disease Relevance 0.56 Pain Relevance 0.62
Rapid elevation of plasma interleukin-6 by morphine is dependent on autonomic stimulation of adrenal gland.
Regulation (dependent) of in autonomic Positive_regulation (elevation) of interleukin-6 in plasma associated with morphine
4) Confidence 0.27 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 11752119 Disease Relevance 0 Pain Relevance 0.83
Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain.
Regulation (role) of Positive_regulation (Increase) of interleukin-6 in spinal cord associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
5) Confidence 0.27 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9813345 Disease Relevance 0.63 Pain Relevance 0.56
OBJECTIVE: To investigate effect of tramadol on c-fos expression in spinal cord dorsal horn and serum IL-6 levels induced by plantar incision in rats.
Spec (investigate) Regulation (effect) of Positive_regulation (induced) of IL-6 in spinal cord dorsal horn associated with tramadol, dorsal horn and spinal cord
6) Confidence 0.27 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 19693978 Disease Relevance 0 Pain Relevance 0.35
The aim of this study was to determine if CGRP in injured nerves is involved in the up-regulation of IL-6 and in the maintenance of neuropathic pain.
Regulation (involved) of Positive_regulation (regulation) of IL-6 in nerves associated with neuropathic pain and calcitonin gene-related peptide
7) Confidence 0.27 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16805807 Disease Relevance 0.93 Pain Relevance 1.17
We examined the effects of the supplementation of inhalational anaesthesia with either 3 or 15 micrograms.kg-1 fentanyl on the circulating interleukin-6, interleukin-8, C-reactive protein, cortisol and glucose concentrations in 16 patients undergoing pelvic surgery.
Spec (examined) Regulation (effects) of Positive_regulation (circulating) of interleukin-6
8) Confidence 0.18 Published 1997 Journal Anaesthesia Section Abstract Doc Link 9059091 Disease Relevance 0 Pain Relevance 0.20
was unchanged, IL-6 and IL-10 were increased (p < 0.05) in the recovered group, when compared with all other groups.
Neg (unchanged) Regulation (unchanged) of Positive_regulation (increased) of IL-6
9) Confidence 0.16 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.31 Pain Relevance 0.09
Systemic concentrations of tumour necrosis factor alpha (TNF), interleukin-1 beta (IL-1), interleukin-6 (IL-6), cortisol, epinephrine and norepinephrine were measured before and during the operation and subsequently for up to 48 h postoperatively.
Regulation (measured) of Positive_regulation (concentrations) of interleukin-6
10) Confidence 0.02 Published 1999 Journal Acta Anaesthesiol Scand Section Body Doc Link 10027020 Disease Relevance 0 Pain Relevance 0

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