INT64718

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 9.37
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, IL6) aging (IL1B, IL6) extracellular region (IL1B, IL6)
cytosol (IL1B) signal transduction (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
synovial cells 4
joint 2
macrophage 2
chondrocytes 2
smooth muscle cells 2
IL1B (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 246 100.00 Very High Very High Very High
chemokine 67 99.80 Very High Very High Very High
diclofenac 3 98.72 Very High Very High Very High
rheumatoid arthritis 302 98.50 Very High Very High Very High
Snapping jaw 20 97.88 Very High Very High Very High
Osteoarthritis 66 97.56 Very High Very High Very High
Arthritis 80 96.80 Very High Very High Very High
Inflammation 212 96.04 Very High Very High Very High
cINOD 12 92.60 High High
Inflammatory mediators 5 89.96 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 305 98.50 Very High Very High Very High
Temporomandibular Joint Syndrome 20 97.88 Very High Very High Very High
Experimental Arthritis 21 97.84 Very High Very High Very High
Osteoarthritis 87 97.56 Very High Very High Very High
Anaplastic Astrocytoma 2 96.96 Very High Very High Very High
Necrosis 21 96.80 Very High Very High Very High
Cancer 24 96.44 Very High Very High Very High
INFLAMMATION 227 96.04 Very High Very High Very High
Arthritis 80 94.96 High High
Diabetic Foot Ulcer 30 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-1 beta induces interleukin-6 mRNA expression and protein production in synovial cells from human temporomandibular joint.
Interleukin-1 beta Positive_regulation (induces) of Gene_expression (expression) of interleukin-6 mRNA in synovial cells associated with snapping jaw
1) Confidence 0.59 Published 2002 Journal J. Oral Pathol. Med. Section Title Doc Link 12190816 Disease Relevance 0.37 Pain Relevance 0.50
IL-1 beta increased IL-6 production in HTS cells.
IL-1 beta Positive_regulation (increased) of Gene_expression (production) of IL-6
2) Confidence 0.59 Published 2002 Journal J. Oral Pathol. Med. Section Body Doc Link 12190816 Disease Relevance 0.08 Pain Relevance 0
IL-1 beta also stimulated IL-6 mRNA expression.
IL-1 beta Positive_regulation (stimulated) of Gene_expression (expression) of IL-6
3) Confidence 0.43 Published 2002 Journal J. Oral Pathol. Med. Section Body Doc Link 12190816 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: IL-1 beta increased IL-6 production in synovial cells resulting from an increase in IL-6 mRNA expression.
IL-1 beta Positive_regulation (increased) of Gene_expression (production) of IL-6 in synovial cells
4) Confidence 0.43 Published 2002 Journal J. Oral Pathol. Med. Section Body Doc Link 12190816 Disease Relevance 0.06 Pain Relevance 0
Tenidap, naproxen and meloxicam inhibited the IL-1 beta-induced synthesis of IL-6, whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect.
IL-1 Positive_regulation (induced) of Gene_expression (synthesis) of IL-6 associated with diclofenac
5) Confidence 0.41 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.60 Pain Relevance 0.51
Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production.
IL-1 Neg (not) Positive_regulation (stimulated) of Gene_expression (production) of IL-6 in chondrocytes
6) Confidence 0.34 Published 1999 Journal Clin. Exp. Rheumatol. Section Body Doc Link 10342040 Disease Relevance 0 Pain Relevance 0
Leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2, and production of NO, PGE2, IL-6, and IL-8.
IL-1 Positive_regulation (enhanced) of Gene_expression (production) of IL-6
7) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2726438 Disease Relevance 0.79 Pain Relevance 0.27
Together, TNF and IL-1 stimulate the production of IL-6 by smooth muscle cells (Ng et al 1994).
IL-1 Positive_regulation (stimulate) of Gene_expression (production) of IL-6 in smooth muscle cells
8) Confidence 0.15 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993951 Disease Relevance 1.52 Pain Relevance 0.43
stimulates expression of IL-1 and IL-6, and IL-1 can induce both IL-6 and TNF-?
IL-1 Positive_regulation (induce) of Gene_expression (expression) of IL-6
9) Confidence 0.07 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.42 Pain Relevance 0.35
In addition, IL-1 and TNF induce the production of IL-6 and chemokines (e.g.
IL-1 Positive_regulation (induce) of Gene_expression (production) of IL-6 associated with chemokine
10) Confidence 0.02 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 1.29 Pain Relevance 0.60
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
IL-1 Positive_regulation (induced) of Gene_expression (production) of IL-6
11) Confidence 0.02 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.39 Pain Relevance 0.04
Although IL-6 is mostly produced by synovial fibroblasts and only partly by macrophages [141], two findings suggest that the striking IL-6 rise is a prominent outcome of macrophage activation: the morphological vicinity of IL-6-expressing fibroblasts with CD14+ macrophages in the RA synovial tissue [141]; and the in vitro and coculture studies [63] that showed that IL-1 stimulates IL-6 production.


IL-1 Positive_regulation (stimulates) of Gene_expression (production) of IL-6 in macrophage associated with rheumatoid arthritis
12) Confidence 0.02 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.81 Pain Relevance 0.45
in the RA synovial tissue (reviewed in [2]) and (b) co-culture studies showing that IL-1 stimulates IL-6 production [17].
IL-1 Positive_regulation (stimulates) of Gene_expression (production) of IL-6 associated with rheumatoid arthritis
13) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.11 Pain Relevance 0.47
Since there was no significant difference in the IL-6 production induced by IL-1?
IL-1 Positive_regulation (induced) of Gene_expression (production) of IL-6
14) Confidence 0.01 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.26 Pain Relevance 0.28
IL-1 and TNF stimulate the production of degradative proteases and cytokines such as IL-1, IL-6, IL-8 and MCP-1 by joint tissue cells, contributing to joint destruction.
IL-1 Positive_regulation (stimulate) of Gene_expression (production) of IL-6 in joint associated with cytokine
15) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.62 Pain Relevance 0.57

General Comments

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